Pathofysiologisch mechanisme Roken/inflammatie systemische effecten Spill-over theory
TNF-alfa RANTES MCP-i IL-8 1CAM ALZHEIMER S DISEASE DEMENTIA ATHEROSCLEROSIS CONGESTIVE HEART FAILURE ISCHEMIC HEART DISEASES: Angina Pectoris Myocardial Infarction INSULINE RESISTANCE TYPE 2 DIABETES CEREBROVIASCULAR DISEASES: Stroke Transient Cerebral Ischemia ANOREXIA Inflamm- Ageing ANAEMIA AUTOIMMUNE DISEASES: Rheumatoid Arthritis IL-6 TNF-alfa CHRONIC PULMONARY DISEASES: Chronic Bronchitis Asthma Emphysema OSTEOPOROSIS ARTHROSIS SARCOPENIA DISABILITY THROMBOEMBOLIC MANIFESTATIONS De Martinis et al, Exp Mol Path 2006
50 45 40 35 30 25 20 15 10 5 0 De Cijfers Mild (I) Matig (II) Ernstig (III) Zeer ernstig (IV) L Steuten et al. Prim Care Resp J 2005 BMI < 21 kg/m 2 BMI > 30
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73% 15% 1% 11% Normal BMI and normal FFMI low BMI and normal FFMI low BMI and low FFMI Normal BMI and low FFMI