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1 List of publications

2 180 LIST OF PUBLICATIONS van Looij MA*, Liem SS*, van der Burg H, van der Wees J, De Zeeuw CI, van Zanten BG. Impact of conventional anesthesia on auditory brainstem responses in mice. Hear Res. 2004;193(1-2):75-82 van der Wees J, van Looij MA, de Ruiter MM, Elias H, van der Burg H, Liem SS, Kurek D, Engel JD, Karis A, van Zanten BG, de Zeeuw CI, Grosveld FG, van Doorninck JH. Hearing loss following Gata3 haploinsufficiency is caused by cochlear disorder. Neurobiol Dis. 2004;16(1): Van der Velde ET, Liem SS, van der Hoeven BL, Witteman TA, Foeken H, Oemrawsingh PV, Schalij MJ Multi-vendor solution for reception and review of ECG to shorten treatment delay in AMI patients. Computers in Cardiology 2005; 32:61-63 van der Hoeven BL, Liem SS, Oemrawsingh PV, Dijkstra J, Jukema JW, Putter H, Atsma DE, van der Wall EE, Bax JJ, Reiber JC, Schalij MJ. Role of calcified spots detected by intravascular ultrasound in patients with STsegment elevation acute myocardial infarction. Am J Cardiol. 2006;98(3): Liem SS, van der Hoeven BL, Oemrawsingh PV, Bax JJ, van der Bom JG, Bosch J, Viergever EP, van Rees C, Padmos I, Sedney MI, van Exel HJ, Verwey HF, Atsma DE, van der Velde ET, Jukema JW, van der Wall EE, Schalij MJ MISSION!: Optimization of acute and chronic care for patients with acute myocardial infarction. Am Heart J 2007;153:14.e1214.e11 Liem SS, Jukema JW, Schalij MJ Response to the letter to the Editor by van de Werf. Am Heart J 2007;153:e35. Mollema SA, Bleeker GB, Liem SS, Boersma E, van der Hoeven BL, Holman ER, van der Wall EE, Schalij MJ, Bax JJ. Does left ventricular dyssynchrony immediately after acute myocardial infarction result in left ventricular dilatation? Heart Rhythm. 2007;4(9): Mollema SA, Liem SS, Suffoletto MS, Bleeker GB, van der Hoeven BL, van de Veire NR, Boersma E, Holman ER, van der Wall EE, Schalij MJ, Gorcsan J 3rd, Bax JJ.

3 List of publications Left ventricular dyssynchrony acutely after myocardial infarction predicts left ventricular remodeling. J Am Coll Cardiol. 2007;50(16): van der Hoeven BL, Liem SS, Jukema JW, Suraphakdee N, Putter H, Dijkstra J, Atsma DE, Bootsma M, Zeppenfeld K, Oemrawsingh PV, van der Wall EE, Schalij MJ. Sirolimus-eluting stents versus bare-metal stents in patients with ST-segment elevation myocardial infarction: 9-month angiographic and intravascular ultrasound results and 12-month clinical outcome results from the MISSION! Intervention Study. J Am Coll Cardiol. 2008; 51(6): de Jager SC, Kraaijeveld AO, Grauss RW, de Jager W, Liem SS, van der Hoeven BL, Prakken BJ, Putter H, van Berkel TJ, Atsma DE, Schalij MJ, Jukema JW, Biessen EA. CCL3 (MIP-1 alpha) levels are elevated during acute coronary syndromes and show strong prognostic power for future ischemic events. J Mol Cell Cardiol. 2008; 45(3): Hassan AKM, Liem SS, van der Kley F, Bergheanu SC, Wolterbeek R, Bosch J, van der Laarse A, Atsma DE, Jukema JW, Schalij MJ In-ambulance abciximab administration in STEMI patients prior to primary PCI is associated with smaller infarct size, improved LV function and lower incidence of heart failure. Eur Heart J. 2008; Supplement:136 Liem SS, van der Hoeven BL, Mollema SA, Bosch J, van der Bom JG, Viergever EP, van Rees C, Bootsma M, van der Velde ET, Jukema JW, van der Wall EE, Schalij MJ Optimization of acute and long-term care for acute myocardial infarction patients: The Leiden MISSION! project. Submitted Liem SS, Oemrawsingh PV, Cannegieter SC, Le Cessie S, Schreur J, Rosendaal FR, Schalij MJ Cardiovascular risk in young apparently healthy descendents from Asian Indian migrants in the Netherlands: the SHIVA study. Netherlands Heart Journal (in press) Hassan AKM, Bergheanu SC, Hasan-Ali H, Liem SS, van der Laarse A, Wolterbeek R, Atsma DE, Schalij MJ, Jukema JW Usefulness of peak troponin-t to predict infarct size and long-term outcome in patients with first acute myocardial infarction after primary percutaneous coronary intervention. Am J Cardiol. (in press)

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5 Curriculum Vitae

6

7 Curriculum Vitae Su-San Liem, the author of this thesis, was born on June 18, 1976 in Tegelen, The Netherlands. After having been awarded her Gymnasium (high school) diploma by the Collegium Marianum in Venlo, she started studying medicine at the Catholic University of Leuven in Belgium in There she obtained her candidature diploma and completed the first two doctoral years. She returned to the Netherlands and carried out research at the Department of Anatomy at the Erasmus University of Rotterdam for a period of seven months. The research was in the field of Auditory Brainstem Response in mice and was carried out under the supervision of Prof. Dr. L. Feenstra and Prof. Dr. C.I. de Zeeuw. In 2001 she started her internship at the Erasmus University and obtained her medical degree with distinction in April For a short period of time she worked as a resident at the Department of Internal Medicine at the Reinier de Graaf Hospital in Delft. In February 2004, she started her official training in cardiology under an AGIKO scholarship at the Leiden University Medical Center. Under the supervision of Prof. Dr. M.J. Schalij and Prof. Dr. E.E. van der Wall she implemented an all-phased integrated care program for patients with an acute myocardial infarction: the MISSION! protocol. The results of this protocol and other studies carried out are described in this thesis. Over the course of her time carrying out scientific research she was an abstract grader of the Quality of Care and Outcomes Research in Cardiovascular Disease and Stroke Conference of the American Heart Association in She was a finalist for the Geoffrey Rose Young Investigator Award at the EuroPRevent congress of the European Society of Cardiology in Madrid Furthermore, she was active in the Committee of Cardiovascular Prevention and Cardiac Rehabilitation of The Netherlands Society of Cardiology. Since September 2007, she has been working at the Department of Internal Medicine at the Bronovo hospital, The Hague (pre-training for cardiologist, educational head Dr. J.W. van t Wout). Her traineeship will be continued at the Department of Cardiology at the HAGA hospital in The Hague (educational head Dr. B.J.M. Delemarre), and at the Department of Cardiology at the Leiden University Medical Center (educational head Prof. Dr. E.E. van der Wall). 185 Su-San Liem, de auteur van dit proefschrift, werd geboren op 18 juni 1976, te Tegelen. In 1994 behaalde zij het β-gymnasium eindexamen aan het Collegium Marianum te Venlo. In hetzelfde jaar startte zij met de studie geneeskunde aan de Katholieke Universiteit Leuven in Leuven, België. Zij behaalde daar haar diploma kandidatuursjaren en de eerste twee doctoraaljaren. Hierna ging zij terug naar Nederland. Gedurende 7 maanden deed zij onderzoek op het gebied van Auditory Brainstem Response bij muizen, onder begeleiding van prof. dr. L. Feenstra en prof. dr. C.I. de Zeeuw op de

8 186 afdeling anatomie van de Erasmus Universiteit te Rotterdam. In 2001 startte ze met haar co-schappen geneeskunde eveneens aan de Erasmus Universiteit te Rotterdam en behaalde haar artsexamen cum laude in april Hierna was ze korte tijd werkzaam als AGNIO Interne geneeskunde in het Reinier de Graaf ziekenhuis te Delft. Sinds februari 2004 is zij als AGIKO verbonden aan de afdeling hartziekten van het Leids Universitair Medisch Centrum te Leiden. Onder begeleiding van prof. dr. M.J. Schalij en prof. dr. E.E. van der Wall zette zij een intensief zorgprogramma op voor patiënten met een acuut hartinfarct: het MISSION! protocol. De resultaten van dit protocol en andere door haar verrichte studies staan beschreven in dit proefschrift. Tijdens haar onderzoeksperiode was zij abstract grader voor de Quality of Care and Outcomes Research in Cardiovascular Disease and Stroke Conference van de American Heart Association in Zij was finaliste voor de Geoffrey Rose Young Investigator Award tijdens EuroPRevent van de European Society of Cardiology in Madrid Verder was zij actief in de Commissie Cardiovasculaire Preventie en Hartrevalidatie van de Nederlandse Vereniging voor Cardiologie. Op 1 september 2007 startte zij met het klinische gedeelte van haar opleiding tot cardioloog op de afdeling Interne Geneeskunde in het Bronovo Ziekenhuis, te Den Haag (opleider dr. J.W. van t Wout). Dit zal vervolgd worden op de afdeling cardiologie van het HAGA ziekenhuis, te Den Haag (opleider dr. B.J.M Delemarre) en de afdeling cardiologie van het Leids Universitair Medisch Centrum, te Leiden (opleider prof. dr. E.E. van der Wall).

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