Citation for published version (APA): Hartman, H. T. (2017). The burden of myocardial infarction [Groningen]: Rijksuniversiteit Groningen

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1 University of Groningen The burden of myocardial infarction Hartman, Hermina IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below. Document Version Publisher's PDF, also known as Version of record Publication date: 2017 Link to publication in University of Groningen/UMCG research database Citation for published version (APA): Hartman, H. T. (2017). The burden of myocardial infarction [Groningen]: Rijksuniversiteit Groningen Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons). Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Downloaded from the University of Groningen/UMCG research database (Pure): For technical reasons the number of authors shown on this cover page is limited to 10 maximum. Download date:

2 The burden of myocardial infarction Hermina Theresia Hartman

3 Hartman, M.H.T. The burden of myocardial infarction Thesis, University of Groningen, the Netherlands ISBN: Copyright 2017 M.H.T. Hartman, Groningen, the Netherlands All rights reserved. No part of this thesis may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, by photocopying, recording or otherwise, without the prior written permission of the author. Financial support by the following sponsor for the publication of this thesis is gratefully acknowledged: Rijksuniversiteit Groningen, Groningen University Institute for Drug Exploration (GUIDE). Cover graphics: M.H.T.H. Layout and printed by: Optima Grafische Communicatie, Rotterdam, the Netherlands (www.ogc.nl)

4 The burden of myocardial infarction The burden of myocardial infarction Proefschrift Ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen Proefschrift op gezag van de rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties. ter verkrijging De openbare van verdediging de graad zal van plaatsvinden doctor aan op de Rijksuniversiteit Groningen woensdag 15 november 2017 om 11:00 uur op gezag van de rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties. De openbare verdediging door zal plaatsvinden op woensdag 15 november 2017 om 11:00 uur Hermina Theresia Hartman door geboren op 8 maart 1986 te Warnsveld Hermina Theresia Hartman geboren op 8 maart 1986 te Warnsveld

5 Promotor Prof. dr. P. van der Harst Copromotores Dr. I.C.C. van der Horst Dr. E. Lipsic Beoordelingscommissie Prof. dr. G. Pasterkamp Prof. dr. W. H. van Gilst Prof. dr. N. van Royen Financial support by the Dutch Heart Foundation for the publication of this thesis is gratefully acknowledged.

6 Paranimfen Dhr. J.J. Klein Bramel Dhr. R.N. Eppinga

7

8 Table of contents Chapter 1 General introduction 9 Part I Chapter 2 Chapter 3 Prevalence and treatment of cardiovascular disease in the northern part of the Netherlands Unrecognized myocardial infarction and association with mortality in the northern part of the Netherlands Part II Chapter 4 Contemporary value of peak CK-MB after STEMI in predicting 51 infarct size, left ventricular ejection fraction, and mortality Chapter 5 The value of global longitudinal systolic strain after STEMI 71 Part III Chapter 6 Long-term effects of metformin in patients presenting with STEMI 91 Chapter 7 Cytokine inhibition in myocardial infarction and chronic heart 107 failure Chapter 8 Interleukin-6 receptor inhibition in a murine model of myocardial ischemia-reperfusion 135 Chapter 9 General discussion and future perspectives 151 Chapter 10 Nederlandse samenvatting 165 Appendix Dankwoord 173 Curriculum Vitae 177 List of publications 179

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