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1 Cover Page The handle holds various files of this Leiden University dissertation. Author: Wijnmaalen, Adrianus Pieter Title: Substrate of ventricular tachycardia Issue Date:

2 List of publications

3 From wastepaper basket; Total AV block?! Wijnmaalen AP, van den Berg TM, Delemarre BJM. Neth Heart J 2006; 6, 232 & 238. Patients with scar-related right ventricular tachycardia: determinants of long-term outcome. Wijnmaalen AP, Schalij MJ, Bootsma M, Kies P, DE Roos A, Putter H, Bax JJ, Zeppenfeld K. J Cardiovasc Electrophysiol Oct;20(10): Early reperfusion during acute myocardial infarction affects ventricular tachycardia characteristics and the chronic electroanatomic and histological substrate. Wijnmaalen AP, Schalij MJ, von der Thüsen JH, Klautz RJ, Zeppenfeld K. Circulation May 4;121(17): Beneficial effects of catheter ablation on left ventricular and right ventricular function in patients with frequent premature ventricular contractions and preserved ejection fraction. Wijnmaalen AP, Delgado V, Schalij MJ, van Huls van Taxis CF, Holman ER, Bax JJ, Zeppenfeld K. Heart Aug;96(16): Head-to-head comparison of contrast-enhanced magnetic resonance imaging and electroanatomical voltage mapping to assess post-infarct scar characteristics in patients with ventricular tachycardias: real-time image integration and reversed registration. Wijnmaalen AP, van der Geest RJ, van Huls van Taxis CF, Siebelink HM, Kroft LJ, Bax JJ, Reiber JH, Schalij MJ, Zeppenfeld K. Eur Heart J Jan;32(1): Ventricular tachycardia ablation: indications and techniques. Wijnmaalen AP, Zeppenfeld K. Minerva Cardioangiol Apr;59(2): ECG Identification of Scar-Related Ventricular Tachycardia with a Left Bundle Branch Block Configuration. Wijnmaalen AP, Stevenson WG, Schalij MJ, Field ME, Stephenson K, Tedrow UB, Koplan BA, Putter H, Epstein LM, Zeppenfeld K. Circ Arrhythm Electrophysiol Apr 1;4(2):

4 Early reperfusion therapy affects inducibility, cycle length, and occurrence of ventricular tachycardia late after myocardial infarction. Wijnmaalen AP, Piers SR, Borleffs CJ, van Huls van Taxis CF, Thijssen J, van Rees JB, Cannegieter SC, Bax JJ, Schalij MJ, Zeppenfeld K. Circ Arrhythm Electrophysiol Apr 1;4(2): Catheter ablation of ventricular tachycardia after left ventricular reconstructive surgery for ischemic cardiomyopathy. Wijnmaalen AP, Roberts-Thomson KC, Steven D, Klautz RJM, Willems S, Schalij MJ, Stevenson WG, Zeppenfeld K. Heart Rhythm Jan; 9(1):10-7 Longitudinal mechanics of the periinfarct zone and ventricular tachycardia inducibility in patients with chronic ischemic cardiomyopathy. Bertini M, Ng AC, Borleffs CJ, Delgado V, Wijnmaalen AP, Nucifora G, Ewe SH, Shanks M, Thijssen J, Zeppenfeld K, Biffi M, Leung DY, Schalij MJ, Bax JJ. Am Heart J Oct;160(4): List of Publications Epicardial ablation for ventricular tachycardia: a European multicenter study. Della Bella P, Brugada J, Zeppenfeld K, Merino J, Neuzil P, Maury P, Maccabelli G, Vergara P, Baratto F, Berruezo A, Wijnmaalen AP. Circ Arrhythm Electrophysiol Oct;4(5): Reversed polarity of bipolar electrograms for predicting a successful ablation site in focal idiopathic right ventricular outflow tract arrhythmias. van Huls van Taxis CF, Wijnmaalen AP, den Uijl DW, Gawrysiak M, Putter H, Schalij MJ, Zeppenfeld K. Heart Rhythm May;8(5): Real-time integration of MDCT derived coronary anatomy and epicardial fat: Impact on electroanatomical mapping and ablation for ventricular arrhythmias. van Huls van Taxis CF, Wijnmaalen AP, Piers SR, van der Geest RJ, Schalij MJ, Zeppenfeld K. Submittted Real-time integration of intracardiac echocardiography to facilitate atrial tachycardia ablation in a patient with a Senning baffle. den Uijl DW, Blom NA, Wijnmaalen AP, Bax JJ, Schalij MJ, Zeppenfeld K. Circ Arrhythm Electrophysiol Oct;2(5):e28-30

5

6 Dankwoord

7 Dit boek was er niet geweest zonder de hulp en steun van velen. Ik heb met veel plezier aan dit proefschrift gewerkt. Mijn dank gaat uit naar al diegenen die de afgelopen jaren hierbij betrokken waren. Zonder anderen tekort te doen wil ik graag een aantal mensen persoonlijk noemen. 244 De onderzoeken beschreven in dit proefschrift werden gedaan op de afdeling hartziekten van het Leids Universitair Medisch Centrum. Dank aan iedereen met wie ik de afgelopen jaren heb samengewerkt. Dank in het bijzonder aan de dames en heer van het cathlab voor de gezelligheid, effectieve samenwerking en koffie in de vele uren achter Prucka en CARTO. Alle collega s uit de Tuin : Dennis, Maaike, Ellen, Roxana, Jaël, Jan, Jan Willem, Jaap, Rutger, Roderick, Mark, Leontine, Louisa, Joanne, Claudia, Laurens, Sjoerd, Yvo, Daniël, Robert, Hans, Sum-Che, Stijntje, Fleur, Joëlla, Joep, Mihály en Cees, we hebben een geweldige tijd gehad! Dank voor alle lol, creativiteit en adviezen op de werkvloer en tijdens borrels, etentjes en congressen. Carine en Sebastiaan dank dat jullie het stokje hebben overgenomen, jullie doen het geweldig. Verder wil ik mijn collega s uit het Sint Franciscus Gasthuis in Rotterdam en mijn huidige collega s in het LUMC danken voor hun ondersteuning en flexibiliteit. Veel dank ben ik verschuldigd aan vrienden die een belangrijke bijdrage hebben geleverd aan het hooghouden van de moraal. Pieter, Marcel, Tim, Timon, Arian, Leon, Corné, Ruben, Hans, Cornelis en Ab, bedankt voor alle mooie en uitdagende momenten op de fiets en ernaast. Martijn dank voor alle morele support en de vele verhelderende avonden de afgelopen jaren. Pim, jouw verfrissende blik op de zaken blijft een bron van inspiratie. Ik ben blij dat jullie mijn paranimfen willen zijn. Ben en Marjan, jullie staan altijd voor ons klaar, dank dat jullie de ideale schoonouders zijn. Becky, as a mother at distance you have managed to support me nevertheless. Lennard, Thomas en Benno, als broers hoor je een gezond kritische blik te hebben, bedankt voor de goede tijd de afgelopen jaren.

8 Pap en mam mijn dank voor de basis die jullie hebben gelegd en jullie blijvende steun is niet in een paar woorden uit te drukken, ik ben blij met en trots op jullie. Anna en Ard, met jullie is het leven iedere dag opnieuw een feestje! Jullie maken me tot een ongekend trotse vader, binnenkort met z n drieën! Lieve Menke, leven zonder jou is niet voor te stellen. Dank voor wie je bent. Dank voor je onvoorwaardelijke liefde. Ik bewonder je. Ik heb je lief. 245 Dankwoord

9

10 Curriculum Vitae

11 248

12 De auteur van dit proefschrift werd geboren op 2 juli 1980 te Rotterdam. In 1997 en 1999 behaalde hij achtereenvolgens het HAVO diploma aan scholengemeenschap Willem van Oranje te Oud-Beijerland en het VWO diploma aan het Albeda college te Rotterdam. Hierna startte hij met de opleiding Geneeskunde aan de Universiteit Leiden. Na het behalen van het artsexamen in november 2005 heeft hij 10 maanden gewerkt als arts-assistent op de afdeling cardiologie van het HAGA ziekenhuis (opleider Dr. B.J.M. Delemarre). Van 2006 tot 2009 deed hij klinisch promotieonderzoek aan de afdeling cardiolgie van het Leids Universitair Medisch Centrum onder leiding van Prof. Dr. M.J. Schalij en Dr. K. Zeppenfeld naar het substraat van ventriculaire tachycardiën. De resultaten hiervan zijn beschreven in dit proefschrift. Per 1 november 2009 startte hij met de opleiding cardiologie. Deze werd aangevangen met de vooropleiding Interne Geneeskunde in het Sint Franciscus Gasthuis te Rotterdam (opleider A.P. Rietveld). November 2011 is hij teruggekeerd naar het LUMC voor het vervolg van de opleiding cardiologie (opleider Prof. Dr. M.J. Schalij). 249 Curriculum Vitae

13

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