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1 Cover Page The handle holds various files of this Leiden University dissertation. Author: Duinen, Nicolette van Title: Hereditary paragangliomas : clinical studies Issue Date:

2 Curriculum Vitae Nicolette van Duinen werd geboren op 17 juni 1981 te Dordrecht. Zij behaalde haar VWO diploma in 2000 aan het Insula College te Dordrecht. In 2000 werd ze ingeloot voor de studie geneeskunde aan de Universiteit Leiden. In 2007 verrichte zij haar wetenschapsstage op de afdeling endocrinologie van het Leids Universitair Medisch Centrum. Onder begeleiding van Monique Wassenaar deed zij onderzoek naar gewrichtsklachten bij patiënten met acromegalie. Na het behalen van het artsexamen in2008 startte zij met promotie-onderzoek op de afdeling Endocrinologie van het Leids Universitair Medisch Centrum. Onder leiding van Professor dr. J.A. Romijn, Prof. Dr. J.W.A. Smit en Dr. E.P.M. van der Kleij-Corssmit heeft zij wetenschappelijk onderzoek verricht naar paragangliomen. De resultaten van dit onderzoek staan beschreven in dit proefschrift. Sinds januari 2011 is zij werkzaam als arts-assistent in opleiding tot internist in het HagaZiekenhuis te Den Haag. 135

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4 List of publications Wassenaar MJE, Biermasz NR, van Duinen N, van der Klaauw AA, Pereira AM, Roelfsema F, Smit JWA, Kroon HM, Kloppenburg M, Romijn JA. High prevalence of arthropathy, according to the definitions of radiological and clinical osteoarthritis, in patients with long-term cure of acromegaly: a case-control study. European Journal of Endocrinology, 2009 Mar;160 (3): van Duinen N, Steenvoorden D, Kema IP, Jansen JC, Vriends AHJT, Bayley JP, Smit JWA, Romijn JA, Corssmit EPM. Increased urinary excretion of 3-methoxytyramine in patients with head and neck paragangliomas. Journal of Clinical Endocrinology 2010 Jan; 95 (1): van Duinen N, Steenvoorden D, Bonsing BA, Vuyk J, Vriends AHJT, Jansen JC, Romijn JA, Corssmit EPM. Pheochromocytomas detected by biochemical screening in predisposed subjects are associated with a lower prevalence of clinical and biochemical manifestations and smaller tumors than pheochromocytomas detected by signs and symptoms. European Journal of Endocrinology 2010 van Duinen N, Kema IP, Romijn JA, Corssmit EPM. Plasma chromogranin A levels are increased in a small portion of patients with head and neck paragangliomas. Clinical Endocrinology 2010 Hensen EF, van Duinen N, Jansen JC, Corssmit EPM, Romijn JA, Vriends AHJT, van der Meij AGL, Cornelisse CJ, Devilee P, Bayley JP. High prevalence of founder mutations in genes causing hereditary paraganglioma and pheochromocytoma syndrome in the Netherlands. Clinical Genetics 2011 Feb 23 [Epub ahead of print] Biermasz NR, Joustra SD, Donga E, Pereira AM, van Duinen N, van Dijk M, van der Klaauw AA, Corssmit EP, Lammers GJ, van Kralingen KW, van Dijk JG, Romijn JA. Patients previously treated for nonfunctioning pituitary macroadenomes have disturbed sleep characteristics, circadian movement rhythm, and subjective sleep quality. J Clin Endocrinol Metab May;96(5): Epub 2011 Mar 2. Havekes B, Kastelein F, van der Klaauw AA, van Duinen N, Jansen JC, Smit JW, van Kralingen KW, Vriends AH, Romijn JA, Corssmit EP. Head-and-neck paragangliomas are associated with sleep-related complaints, especially in the presence of carotid body tumors. Sleep Breath May 27. [Epub ahead of print] 137

5 van Duinen N, Corssmit EPM, de Jong WHA, Brookman D, Kema IP, Romijn JA. Plasma levels of free metanephrines and 3-methoxytyramine indicate a higher number of biochemically active HNPGL than 24 h urinary excretion rates of catecholamines and metabolites. Submitted for publication van Duinen N, van Kralingen KW, van Dijk JG, Ninaber MK, Havekes B, Smid L, Lammers GJ, Jansen JC, Smit JW, J.A. Romijn, E.P.M. Corssmit. High prevalence of sleep disordered breathing in patients with bilateral carotid body tumors is associated with increased peripheral chemoresponsiveness. Submitted for publication van Hulsteijn LT, van Duinen N, Romijn JA, Smit JWA, Corssmit EPM. Urinary 5-HIAA levels in patients with head and neck paragangliomas. Submitted for publication 138

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