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1 List of publications

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3 List of publications Hoogendam J, Parlevliet ET, Miclea R, Lowik CW, Wit JM, Karperien M. Novel early target genes of parathyroid hormone-related peptide in chondrocytes. Endocrinology 2006;147: Heijboer AC, van den Hoek AM, Parlevliet ET, Havekes LM, Romijn JA, Pijl H, Corssmit EP. Ghrelin differentially affects hepatic and peripheral insulin sensitivity in mice. Diabetologia 2006;49: Parlevliet ET, Heijboer AC, Schroder-van der Elst JP, Havekes LM, Romijn JA, Pijl H, Corssmit EP. Oxyntomodulin ameliorates glucose intolerance in mice fed a high-fat diet. Am J Physiol Endocrinol Metab 2008;294:E142-E147. Parlevliet ET, Schroder-van der Elst JP, Corssmit EP, Picha K, O'Neil K, Stojanovic-Susulic V, Ort T, Havekes LM, Romijn JA, Pijl H. CNTO736, a novel glucagon-like peptide-1 receptor agonist, ameliorates insulin resistance and inhibits very low-density lipoprotein production in high-fat-fed mice. J Pharmacol Exp Ther 2009;328: de Leeuw van Weenen JE, Parlevliet ET, Maechler P, Havekes LM, Romijn JA, Ouwens DM, Pijl H, Guigas B. The dopamine receptor D2 agonist bromocriptine inhibits glucosestimulated insulin secretion by direct activation of the alpha2-adrenergic receptors in beta cells. Biochem Pharmacol 2010;79: Parlevliet ET, de Leeuw van Weenen JE, Romijn JA, Pijl H. GLP-1 treatment reduces endogenous insulin resistance via activation of central GLP-1 receptors in mice fed a highfat diet. American Journal of Physiology - Endocrinology & Metabolism: 2010;299:E318- E324 Coomans CP, Guigas B, van den Hoek AM, Geerling JJ, Parlevliet ET, Ouwens DM, Pijl H, Rensen PCN, Voshol PJ, Havekes LM, Romijn JA. Circulating insulin stimulates fatty acid retention in white adipose tissue via K ATP channel activation in the central nervous system. Submitted. Hu L, Berbée JFP, Parlevliet ET, van Vlijmen BJM, Havekes LM, Tamsma JT. The plasma PAI- 1 levels are not affected by the clearance in insulin resistant mice. Submitted. 123

4 Parlevliet ET, Schröder-van der Elst JP, Picha K, O Neil K, Stojanovic-Susulic V, Ort T, Havekes LM, Romijn JA, Pijl H. CNTO736, a novel GLP-1 receptor agonist, ameliorates insulin resistance and inhibits very low density lipoprotein production in high-fat-fed mice. In preparation. Parlevliet ET, Schaper F, Schröder-van der Elst JP, Coomans CP, Lundgren K, Little PB, Elling CE, Pijl H. Obinepitide, a novel Y2/Y4 agonist, and TM30339, a novel Y4 agonist, reduce insulin resistance in high-fat-fed C57Bl/6J mice. In preparation. 124

5 Curriculum Vitae

6 126

7 Curriculum Vitae Edwin Tijmen Parlevliet werd geboren op 4 oktober 1981 te Katwijk (Zuid-Holland). In 2000 behaalde hij zijn VWO diploma aan het Andreas College locatie Pieter Groen te Katwijk. In datzelfde jaar begon hij aan de studie Biomedische Wetenschappen aan de Universiteit Leiden. Hiervoor werd in 2001 de propedeuse behaald. In 2003 werd het Bachelor of Science behaald. In het kader van de Master of Science opleiding volgde hij in 2003 een stage op de afdeling Endocrinologie van het Leids Universitair Medisch Centrum (LUMC), waarin hij onderzoek deed naar nieuwe target genen van PTHrP tijdens de botgroei onder begeleiding van Drs. J. Hoogendam en prof. M. Karperien. In 2004 volgde een afstudeerstage bij de afdeling Biomedisch onderzoek van TNO Kwaliteit van Leven in Leiden, onder begeleiding van Drs. A.C. Heijboer. Deze wetenschappelijke stage richtte zich op effecten van het darmhormoon oxyntomoduline op het glucose metabolisme in de muis, waar over ook de afstudeerscriptie werd geschreven. Na zijn afstuderen in 2005 werd hij in oktober van dat jaar aangesteld als promovendus op de afdeling Endocrinologie van het LUMC. Onder begeleiding van Prof. Dr. H. Pijl werd het in het proefschrift beschreven onderzoek verricht. In 2008 ontving hij de EFSD/ Amylin Paul Langerhans Grant. 127

8 128

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