Curriculum Vitae 315 CURRICULUM VITAE

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1 Curriculum Vitae 315 CURRICULUM VITAE Agatha van der Klaauw werd geboren op 14 maart 1980 te Leiderdorp. Zij behaalde in 1998 het eindexamen aan het Stedelijk Gymnasium te Leiden. In 1999 haalde zij cum laude het propaedeutisch examen Geneeskunde. In 2002 deed zij onderzoek op de afdeling Nucleaire Geneeskunde te Leiden waarna zij in 2002 cum laude het doctoraal examen Geneeskunde behaaldde. Het artsexamen werd cum laude behaald in Direct aansluitend werd met dit promotie-onderzoek begonnen op de afdeling Endocrinologie onder leiding van Professor Romijn en Professor Smit. In 2007 werd een ZonMW-AGIKO stipendium toegekend. Van september 2007 tot september 2008 deed zij onderzoek in de Metabolic Research Laboratories, Institute of Metabolic Science, Cambridge University onder leiding van Professor O Rahilly en Dr Farooqi naar patienten met melanocortine 4-receptor deficientie. In 2008 werd haar de Young Investigator s Award van de European Society of Endocrinology toegekend. Tevens was zij dit jaar winnaar van de Trainee Poster Competition van op de Endocrine Society Meeting in San Francisco. Agatha van der Klaauw is sinds september in opleiding tot internist (als AGIKO) in het Bronovo Ziekenhuis (Opleiders: Professor Romijn en dr. van t Wout). Agatha BW.indd /29/08 3:19:33 PM

2 PUBLICATIES AA van der Klaauw, T van der Straaten, R Baak-Pablo, NR Biermasz, HJ Guchelaar, AM Pereira, JWA Smit, JA Romijn Influence of the d3-growth hormone (GH) receptor isoform on short-term and long-term treatment response to GH replacement in GH-deficient adults. J Clin Endocrinol Metab : AA van der Klaauw, NR Biermasz, AM Pereira, KW van Kralingen, OM Dekkers, KF Rabe, JWA Smit, JA Romijn. Patients cured from craniopharyngioma or non-functioning pituitary macroadenoma suffer similarly from increased daytime somnolence despite normal sleep patterns compared to healthy controls. Clin Endocrinol (Oxf) 2008 in press AA van der Klaauw, M Kars, NR Biermasz, F Roelfsema, OM Dekkers, EPM Corssmit, MO van Aken, B Havekes, AM Pereira, H Pijl, JWA Smit, JA Romijn JA Disease specific impairments in quality of life during long-term follow-up of patients with different pituitary adenomas. Clin Endocrinol (Oxf) 2008 in press Publicaties AA van der Klaauw, JJ Bax, JWA Smit, ER Holman, V Delgado, GB Bleeker, NR Biermasz, F Roelfsema, JA Romijn, AM Pereira Increased aortic root diameters in patients with acromegaly. Eur J Endocrinol : AA van der Klaauw, AM Pereira, TJ Rabelink, EPM Corssmit, AJ van Zonneveld, H Pijl, HC de Boer, JWA Smit, JA Romijn, EJP de Koning Recombinant human GH replacement increases CD34+ cells and improves endothelial function in adults with GH deficiency. Eur J Endocrinol : AA van der Klaauw, AM Pereira, KW van Kralingen, KF Rabe, JA Romijn Somatostatin analog treatment is associated with an increased sleep latency in patients with long-term biochemical remission of acromegaly. Growth Horm IGF Res : AA van der Klaauw, JJ Bax, GB Bleeker, ER Holman, V Delgado, JWA Smit, JA Romijn, AM Pereira Cardiac manifestations of growth hormone deficiency after treatment for acromegaly: a comparison to patients with biochemical remission and controls. Eur J Endocrinol 2008 In press AA van der Klaauw, T Kienitz, CJ Strasburger, JWA Smit, JA Romijn. Malignant Pituitary Corticotroph Adenomas: Report of Two Cases and a Comprehensive Review of the Literature. Pituitary, 2008, in press. Agatha BW.indd 316

3 Publicaties 317 B Havekes, AA van der Klaauw, HC Hoftijzer, JC Jansen, AGL van der Mey, AHJT Vriends, JWA Smit, JA Romijn, EPM Corssmit. Reduced Quality of Life in Patients with Head-and-Neck Paragangliomas. European Journal of Endocrinology, 2008, in 158: AA van der Klaauw, NR Biermasz, HC Hoftijzer, AM Pereira, JA Romijn. Previous radiotherapy negatively influences quality of life during four years of follow-up in patients cured from acromegaly. Clinical Endcrinology, 2008, 69: AA van der Klaauw, NR Biermasz, PMJ Zelissen, AM Pereira, EGWM Lentjes, JWA Smit, SW van Thiel, JA Romijn, F Roelfsema. Administration route-dependent effects of estrogens on IGF-I levels during fixed growth hormone replacement in women with hypopituitarism. European Journal of Endocrinology, 2007, Dec;157(6): AA van der Klaauw, OM Dekkers, AM Pereira, KW van Kralingen, JA Romijn. Increased daytime somnolence despite normal sleep patterns in patients treated for non-functioning pituitary macroadenoma. Journal of Clinical Endocrinology and Metabolism, 2007, Oct;92(10): M Kars, AA van der Klaauw, AM Pereira, JA Romijn. Impaired Quality of Life in Patients Treated for Microprolactinoma. European Journal of Endocrinology, 2007, Jan;93(1): OM Dekkers, AM Pereira, F Roelfsema, AA van der Klaauw, PJ Honkoop, JWA Smit, RJW de Keizer, JA Romijn. Continuing improvement of visual acuity until one year after transspenoidal surgery for non-functioning pituitary adenoma. Pituitary, 2007, 10 (1) AA van der Klaauw, NR Biermasz, EJM Feskens, MB Bos, JWA Smit, F Roelfsema, EPM Corssmit, H Pijl, JA Romijn, AM Pereira. The prevalence of the metabolic syndrome is increased in patients with growth hormone deficiency, irrespective of long-term substitution with recombinant human growth hormone. European Journal of Endocrinology, 2007 Apr;156(4): AA van der Klaauw, AM Pereira, SW van Thiel, M Frolich, A Iranmanesh, JD Veldhuis, F Roelfsema, JA Romijn. Attenuated pulse size and disorderly growth hormone secretion and prolactin secretion with preserved nyctohemeral rhythm distinguish irradiated from surgically treated acromegalic patients. Clinical Endocrinology (Oxf), 2007 Apr;66(4): AA van der Klaauw, JA Romijn, NR Biermasz, JWA Smit, J van Doorn, OM Dekkers, F Roelfsema, AM Pereira. Sustained effects of recombinant growth hormone replacement after 7 years of treatment in adults with growth hormone deficiency. European Journal of Endocrinology, 2006 Nov;155(5): Agatha BW.indd 317

4 OM Dekkers, AA van der Klaauw, AM Pereira, NR Biermasz, PJ Honkoop, F Roelfsema, JWA Smit and JA Romijn. Quality of Life is decreased after treatment for non-functioning pituitary macroadenoma. Journal of Clinical Endocrinology and Metabolism, 2006 Sep;91(9): AA van der Klaauw, AM Pereira, SW van Thiel, JWA Smit, EPM Corssmit, NR Biermasz, M Frolich, A Iranmanesh, JD Veldhuis, F Roelfsema and JA Romijn. Growth hormone (GH) deficiency in patients irradiated for acromegaly: significance of GH stimulatory tests in relation to the twentyfour hour GH secretion. European Journal of Endocrinology, 2006, Jun 154(6): AA van der Klaauw, JJ Bax, F Roelfsema, GB Bleeker, ER Holman, EPM Corssmit, EE van der Wall, JWA Smit, JA Romijn and AM Pereira. Uncontrolled Acromegaly is Associated with Progressive Mitral Valvular Regurgitation. Growth Hormone and IGF Research, 2006, Apr 16(2): Publicaties 318 AM Pereira, AA van der Klaauw, HPF Koppeschaar, JWA Smit, SW van Thiel, J van Doorn, NR Biermasz, F Roelfsema and JA Romijn. Efficacy of needle-free administration of recombinant human growth hormone in adults with growth hormone deficiency. Br J of Clinical Pharmacology, 2006, Apr 61(4): EKJ Pauwels, AA van der Klaauw, T Corporaal and MPM Stokkel. Fluorine-18-radiolabeled pharmaceuticals for imaging with positron emission tomography, excluding [18F]-fluorodeoxyglucose. Drugs of the Future 2002, 27(7): van der Klaauw AA, Bax JJ, Roelfsema F, Stokkel M, Bleeker GB, Biermasz NR, Smit JWA, Romijn JA, Pereira AM. Limited Effects of Growth Hormone Replacement n Patients with GH deficiency During Long-Term Cure of Acromegaly. Submitted for publication van der Klaauw AA, Biermasz NR, van Someren E, Roelfsema F, Smit JWA, Pereira AM, Romijn JA. Postoperative radiotherapy for acromegaly delays the circadian phase of melatonin secretion. Submitted for publication Martinelli CE, Keogh JM, Greenfield JR, Henning E, van der Klaauw AA, Blackwood A, O Rahilly S, Roelfsema F, Camacho-Hübner C, Pijl H, Farooqi IS. Obesity due to Melanocortin 4 receptor (MC4R) deficiency is associated with increased linear growth and final height, fasting hyperinsulinaemia and incompletely suppressed growth hormone secretion. Submitted for publication Agatha BW.indd 318

5 Publicaties 319 Wassenaar MJE, Biermasz NR, van Duinen N, van der Klaauw AA, Pereira AM, Roelfsema F, Smit JWA, Kroon HM, Kloppenburg M, Romijn JA. High prevalence of arthropathy, according to the definitions of radiological and clinical osteoarthritis, in patients with long-term cure of acromegaly; a case control study. Submitted for publication. Wassenaar MJE, Biermasz NR, Pereira AM, van der Klaauw AA, Roelfsema F, Smit JWA, Kroon HM, Wolterbeek R, Romijn JA, Kloppenburg MOsteoarthritis is equally prevalent in men and women with long-term controlled acromegaly. Submitted for publication. Agatha BW.indd 319

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