LIST OF PUBLICATIONS. Scientific publications:
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- Arthur Janssen
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1 BIOGRAFIE Christa Christina van Bunderen werd geboren op 11 mei 1982 in de Wieringermeer, Nederland. Na het afronden van het lager onderwijs op De Regenboogschool te Slootdorp, continueerde zij haar opleiding aan de Rijks Scholengemeenschap Wiringherlant te Wieringerwerf waar zij haar diploma voor het atheneum behaalde in Op een leeftijd van 18 jaar verhuisde zij naar Amsterdam om met de opleiding Geneeskunde te starten aan het VU medisch centrum (VUmc). In 2007 rondde zij deze opleiding succesvol af met een extra aantekening voor het afstudeerprofiel Endocrinologie, Voortplanting en Metabolisme. Gedurende haar opleiding Geneeskunde was zij onder andere actief als bestuurslid in de medische faculteitsvereniging (MFVU) in 2003 en ging tweemaal voor haar studie naar het buitenland. Onder supervisie van prof. dr. H.A. Delemarrevan de Waal deed ze in 2004 enkele maanden onderzoek naar het metabool syndroom in zwarte vrouwen aan de universiteit van Limpopo in Sovenga, Zuid-Afrika. In 2006 ging ze voor het co-assistentschap tropengeneeskunde naar het St. Walburg s ziekenhuis in Nyangao, Tanzania. Na haar afstuderen in 2007 werkte zij 17 maanden als arts-assistent niet-in-opleiding in het Kennemer Gasthuis (huidig Spaarne Gasthuis) te Haarlem. Januari 2009 startte zij met haar promotietraject op de afdeling Interne Geneeskunde, sectie Endocrinologie van het VUmc onder begeleiding van prof. dr. M.L. Drent en prof. dr. P. Lips. Gedurende haar promotietraject was zij actief als bestuurslid van de promovendivereniging van de Vrije Universiteit en VUmc (ProVU) in In 2012 startte zij haar opleiding tot internist in het Spaarne Ziekenhuis (huidig Spaarne Gasthuis) te Hoofddorp (opleider: dr. A.B. Arntzenius) wat zij combineerde met het voortzetten van haar onderzoeksproject in het kader van een AGIKO stipendium van ZonMw. Dit heeft geresulteerd in dit proefschrift. In 2016 zal zij haar opleiding tot internist voortzetten aan het VUmc (opleider: prof. dr. Y.M. Smulders). 246
2 BIOGRAPHY Christa Christina van Bunderen was born May 11 th 1982 in the Wieringermeer, The Netherlands. After finishing primary school at De Regenboog in Slootdorp, she went on to the R.S.G. Wiringherlant in Wieringerwerf where she graduated in At the age of 18, she moved to Amsterdam to start her medical training at the VU University Medical Center (VUmc). She obtained her MD including a certificate for the profile Endocrinology, Human reproduction and Metabolism in During medical training she was active as a board member in the medical student association (MFVU) in 2003, and went abroad twice. Under supervision of prof.dr. H.A. Delemarre-van de Waal she performed a research project at the University of Limpopo in Sovenga, South Africa, on the metabolic syndrome in black women in Subsequently, she went to St. Walburg s Hospital in Nyangao, Tanzania for a clinical internship in After graduating she worked for 17 months at the Kennemer Hospital (present Spaarne Gasthuis) in Haarlem as a resident (not in training) in Internal Medicine. From January 2009 she worked at the VUmc on her PhD project at the department Internal Medicine, section Endocrinology, under supervision of prof. dr. M.L. Drent and prof. dr. P. Lips. During her PhD project she was active as board member in the PhD organisation of the VU University and VUmc (ProVU) in January 2012 she started her residency (in training) in Internal Medicine at the Spaarne Hospital (present Spaarne Gasthuis), Hoofddorp (supervisor: dr. A.B. Arntzenius), whilst continuing her research at the VUmc, as AGIKO (ZonMw stipendium). This has resulted in the present thesis. In 2016 she will continue her residency at the VUmc (supervisor: prof. dr. Y.M. Smulders). 247
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4 LIST OF PUBLICATIONS Scientific publications: Van Bunderen CC, Meijer RI, Lips P, Kramer MH, Serné EH, Drent ML. Titrating growth hormone dose to high-normal IGF-1 levels has beneficial effects on body fat distribution and microcirculatory function despite causing insulin resistance. Submitted Van Bunderen CC, Lips P, Kramer MH, Drent ML. Effect of low-normal and high-normal IGF-1 levels on memory and wellbeing during growth hormone replacement therapy: a randomized clinical trial in adult growth hormone deficiency. Submitted Van Bunderen CC, Lips P, Kramer MH, Drent ML. Comparison of low-normal and high-normal IGF-1 target levels during growth hormone replacement therapy: a randomized clinical trial in adult growth hormone deficiency. Submitted Van Varsseveld NC, van Bunderen CC, Franken AA, Koppeschaar HP, van der Lely AJ, Drent ML. Fractures in pituitary adenoma patients from the Dutch National Registry of Growth Hormone Treatment in Adults. Submitted Jakobsdottir S, van Nieuwpoort IC, van Bunderen CC, de Ruiter MB, Twisk JWR, Deijen JB, Veltman DJ, Drent ML. Acute and short term effects of caloric restriction on metabolic profile and brain activation in obese, postmenopausal women. Submitted Van Varsseveld NC, van Bunderen CC, Franken AA, Koppeschaar HP, van der Lely AJ, Drent ML. Tumor recurrence or regrowth in adults with nonfunctioning pituitary adenomas using GH replacement therapy - a sub-analysis from the Dutch National Registry of Growth Hormone Treatment in Adults. J Clin Endocrinol Metab 2015; 100(8): Van Varsseveld NC, van Bunderen CC, Sohl E, Comijs HC, Penninx BW, Lips P, Drent ML. Serum insulin-like growth factor 1 and late-life depression: A population-based study. Psychoneuroendocrinology 2015; 54: Van Varsseveld NC, van Bunderen CC, Ubachs DH, Franken AA, Koppeschaar HP, van der Lely AJ, Drent ML. Cerebrovascular events, secondary intracranial tumors, and mortality after radiotherapy for nonfunctioning pituitary adenomas: a subanalysis from the Dutch national registry of growth hormone treatment in adults. J Clin Endocrinol Metab 2015; 100(3): Van Bunderen CC, van Varsseveld NC, Heymans MW, Franken AAM, Koppeschaar HPF, van der Lely AJ, Drent ML. Effect of long-term GH replacement therapy on cardiovascular outcomes in GH deficient patients previously treated for acromegaly: a sub-analysis from the Dutch National Registry of Growth Hormone Treatment in Adults. Eur J Endocrinol 2014; 171(6):
5 Van Bunderen CC, van den Dries CJ, Heymans MW, Franken AAM, Koppeschaar HPF, van der Lely AJ, Drent ML. Effect of long-term GH replacement therapy on cardiovascular outcomes in isolated GH deficiency compared to multiple pituitary hormone deficiencies: a sub-analysis from the Dutch National Registry of Growth Hormone Treatment in Adults. Eur J Endocrinol 2014; 171(2): Van Bunderen CC, van Varsseveld NC, Erfurth EM, Ket JC, Drent ML. Efficacy and safety of growth hormone treatment in adults with growth hormone deficiency: a systematic review of studies on morbidity. Clin Endocrinol (Oxf) 2014; 81(1): Van Bunderen CC, de Weger VA, Griffioen-Keijzer A. Disseminated intravascular coagulation as clinical manifestation of colorectal cancer: a case report and review of the literature. Neth J Med 2014; 72(4): Van Bunderen CC, Oosterwerff MM, van Schoor NM, Deeg D, Lips P, Drent ML. Serum IGF1, metabolic syndrome, and incident cardiovascular disease in older people: a population-based study. Eur J Endocrinol 2013; 168(3): Van Bunderen CC, van Varsseveld NC, Baayen JC, van Furth WR, Aliaga ES, Hazewinkel MJ, Majoie CB, Freling NJ, Lips P, Fliers E, Bisschop PH, Drent ML. Predictors of endoscopic transsphenoidal surgery outcome in acromegaly: patient and tumor characteristics evaluated by magnetic resonance imaging. Pituitary 2013; 16(2): Van Bunderen CC, van Nieuwpoort IC, Arwert LI, Heymans MW, Franken AAM, Koppeschaar HPF, van der Lely AJ, Drent ML. Effect van groeihormoonbehandeling op sterfte bij volwassenen met ernstige groeihormoondeficiëntie Gegevens uit de Landelijke Registratie Groeihormoonbehandeling (LRG) Volwassenen, Nederland. Ned Tijdschr Geneeskd 2012; 156; Van Bunderen CC, van Nieuwpoort IC, Arwert LI, Heymans MW, Franken AAM, Koppeschaar HPF, van der Lely AJ, Drent ML. Does growth hormone replacement therapy reduce mortality in adults with growth hormone deficiency? Data from the Dutch National Registry of Growth Hormone Treatment in Adults. J Clin Endocrinol Metab 2011; 96(10): Van Nieuwpoort IC, van Bunderen CC, Arwert LI, Franken AAM, Koppeschaar HPF, van der Lelij AJ, Twisk JWR, Boers M, Drent ML. Dutch National Registry of GH Treatment in Adults: patient characteristics and diagnostic procedures. Eur J Endocrinol 2011; 164: Van Bunderen CC, van Nieuwpoort IC, van Schoor NM, Deeg D, Lips P, Drent ML. The association of serum insulin-like growth factor-i with mortality, cardiovascular disease and cancer in the elderly: a population-based study. J Clin Endocrinol Metab 2010; 95(10):
6 Van Bunderen CC, Bomers MK, Wesdorp E, Peerbooms P, Veenstra J. Clostridium perfringens septicaemia with massive intravascular haemolysis: a case report and review of the literature. Neth J Med 2010; 68(9): Nanayakkara PWB, van Bunderen CC, Santerse B. A bumpy ride to a discarded diagnosis. Lancet 2007; 369: 436. Nanayakkara PWB, van Bunderen CC, Simsek S, Smulders YM, Pals G. Vascular type of Ehlers-Danlos syndrome in a patient with ruptured aneurysm of the splenic artery. Neth J Med 2006; 64(10): Chapter in book Van Bunderen CC, Drent ML. Groeihormoondeficiëntie. In: Canon van de Endocrinologie. Eds: Elte JW, Geelhoed N, Pijl H. Haarlem: DCHG medische communicatie,
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