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1 Other publications by this author 1. de Ruijter W, Eekhof JAH, Knuistingh Neven A. Kinkhoest. Huisarts Wet 2003;46: den Elzen WP, Groeneveld Y, de Ruijter W, Souverijn JH, le Cessie S, Assendelft WJ, Gussekloo J. Long-term use of proton pump inhibitors and vitamin B12 status in elderly individuals. Aliment Pharmacol Ther 2008;27(6): de Ruijter W, Gussekloo J. Cardiovascular prevention in the over-80 age group is not beneficial. Ned Tijdschr Geneeskd. 2008;152(1):27. Dutch. Erratum in: Ned Tijdschr Geneeskd 2008;152(5): den Elzen WP, Westendorp RG, Frölich M, de Ruijter W, Assendelft WJ, Gussekloo J. Vitamin B12 and folate and the risk of anemia in old age: the Leiden 85-plus Study. Arch Intern Med 2008;168(20):

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3 Nawoord In de jaren waarin dit proefschrift tot stand kwam heb ik mij een bevoorrecht mens gevoeld. De combinatie van wetenschappelijk onderzoek, onderwijs aan huisartsen-in-opleiding en de dagelijkse huisartspraktijk vormde een onuitputtelijke bron van inspiratie. Toegegeven, het schrijven van een proefschrift neemt je een paar jaar volledig in beslag, maar je krijgt er tegelijkertijd veel voor terug. Gaandeweg veranderde het mijn denkwijze en handelen, onomkeerbaar, niet alleen binnen de muren van de spreekkamer, maar ook daarbuiten. Het was fascinerend om dat proces mee te maken. Velen hebben bijgedragen aan het welslagen van dit project. De Leidse mores beletten mij echter de meest direct betrokkenen op deze plaats daarvoor te bedanken, hoe gepast dat ook zou zijn geweest. Marinella Langendoen, hoofd huisartsopleiding van de afdeling Public Health en Eerstelijnsgeneeskunde, heeft mij vanaf het prille begin van harte gesteund in mijn wens de wetenschap in te gaan. Collega s en medewerkers op deze afdeling toonden oprechte interesse in mijn vorderingen en welzijn, en boden mij daarnaast alle mogelijke praktische en intellectuele hulp. Zonder iemand te kort te willen doen verdient Wendy den Elzen daarbij een aparte vermelding: de slimste kamergenoot die men zich kan wensen, grenzeloos hulpvaardig, en bovendien met een feilloze sociale antenne. Ik verheug me erop om binnenkort bij jouw promotie paranimf te zijn. Ditty Samethini dank ik voor de grote inzet die zij toonde om mijn boekje mooi op te maken: wat mij betreft met prachtig resultaat. Veel vrienden volgden mijn proefschrifttraject met belangstelling, maar Hanne van der Waa en Arnold Jongenburger blonken echt uit in het dóórvragen en kritisch meedenken. Vriendschappen als deze zijn mij dierbaar en verdienen eigenlijk meer van mijn tijd en aandacht: een goed voornemen. Frank Kroon, paranimf en vertrouwde rots in de branding: jij en Lydia Schut zijn er gewoon altijd en onvoorwaardelijk, dank daarvoor. Ma, fijn dat je de voltooiing van dit proefschrift meemaakt. Mijn vader zie ik in gedachten glimmen van trots. En dan Aart Hendriks. Mijn dank voor jouw morele en praktische ondersteuning tijdens alle fasen van de totstandkoming van dit proefschrift laat zich niet in woorden vangen, en dat ga ik dus ook niet proberen. Ik ben blij dat we allebei zoveel plezier ontlenen aan ons werk, zonder uit het oog te verliezen dat er in het leven belangrijker zaken zijn. Tegelijk verheug ik mij ook enorm op alle leuke dingen die we in de tweede helft van onze marathon gaan ondernemen, hopelijk blessurevrij. En daarna zien we wel weer verder. 173

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5 Curriculum vitae Wouter de Ruijter was born on 25 October 1962 in Leidschendam, and passed his gymnasium- Loo in He finished medical school at Erasmus University in Rotterdam ( , cum laude). Next, he worked as a house officer in psychiatry, surgery and internal medicine ( ), respectively, and as a researchdoctor in the Rotterdam Cardiovascular Risk Intervention (ROCARI) trial (1991). From he completed his vocational training for general practice at the Department of Public Health and Primary Care of the Leiden University Medical Center, and thereafter he was a full-time general practitioner in the city of Leiden until From 2001 onwards he worked as a part-time general practitioner in Gezondheidscentrum Beverwaard in the city of Rotterdam, and as a teacher and staff-member at the vocational training for general practice at the Department of Public Health and Primary Care of the Leiden University Medical Center. In 2005 he started the research project described in this thesis at the same department. At present, he continues his clinical-epidemiological research into cardiovascular disease in old age, with emphasis on risk prediction and prevention, and also teaches evidence-based medicine at the vocational training for general practice. Ever since 1999 he enjoyed running (and finishing) 11 full marathons, and participated in numerous concerts of the Leiden English Choir and The Incidental Choir. 175

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