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1 Cover Page The handle holds various files of this Leiden University dissertation Author: Smelt, Antonette Title: Treatment of migraine : from clinical trial to general practice Issue Date:

2 Dankwoord 155 Dankwoord Gedurende de afgelopen 7 jaar heb ik me met veel plezier verdiept en bekwaamd in de wetenschap. Daarnaast heb ik de mogelijkheid gekregen om mijn promotietraject te combineren met de huisartsopleiding. Deze combinatie van onderzoek en praktijk was soms lastig, maar de afwisseling maakte vooral dat ik beide met plezier heb gedaan. Het was niet mogelijk geweest om dit traject goed af te ronden zonder de medewerking en steun van heel veel mensen van wie ik er hieronder een aantal in het bijzonder wil noemen. Alle patiënten en huisartsen die hebben deelgenomen aan de verschillende onderzoeksprojecten, van harte dank voor alle tijd die jullie hierin hebben geïnvesteerd. Pim, dank voor de gedegen, positief kritische en motiverende manier waarop je me hebt begeleid. Dankzij jou kent de randomized trial voor mij geen geheimen meer en heb ik kennis kunnen nemen van een scala aan onderzoeksmethoden. Michel, dank voor je kritische blik in de ontwerp- en analysefase van de verschillende projecten en de manier waarop je de deelonderzoeken steeds in het grotere plaatje van het internationale migraineonderzoek plaatste. Jeanet, dank voor de prettige, laagdrempelige manier waarop je me hebt begeleid. Ik kon altijd bij je binnenstappen voor advies of een bemoedigend woord. Je hebt me ook geleerd dat je ook in onderzoek soms ook pragmatische keuzes mag maken. Dat maakte het leven regelmatig een stuk aangenamer. De SBOH en mijn huisartsopleiders Clem Snoeck en Hans van Selm, dank voor de ruimte die jullie me hebben gegeven om huisartsopleiding en onderzoek te combineren, ook als dat niet altijd handig uitkwam in de praktijk. Medewerkers van het secretariaat WO van de afdeling Public Health en Geneeskunde, dank voor alle ondersteuning. Ditty en Anita, dank voor jullie inzet bij het ontwerpen, scannen en versturen van de vragenlijsten. Corrie, dank voor het coördineren en uitvoeren van de logistiek in de laatste fase van het traject. Henk, dank voor je onmisbare ondersteuning op het gebied van de ICT. Je stond altijd klaar, of het nu ging om het selecteren van patiënten, het ontwerpen van een database of het oplossen van de dagelijkse computerproblemen.

3 156 Dankwoord Wetenschapsstudenten Jackelien, Marlies en Simon, dank voor de samenwerking. Jullie hebben goed werk verzet en mogen daar trots op zijn. Collega-onderzoekers op de afdeling PHEG, dank voor de manier waarop we afgelopen jaren met elkaar konden meeleven tijdens de informele momenten op de kamer en bij de lunch en van elkaar konden leren tijdens de wetenschapsbesprekingen en andere overleggen. Gelukkig blijf ik aan de afdeling verbonden en kunnen we elkaars wel en wee blijven volgen. Collega-aiotho s Rosalinde, Anne, Annemarije, Sjoerd, Persijn, Marissa, Clare en Anne en aiotho-coördinator Wouter, fijn om met jullie regelmatig te kunnen sparren over de ups en downs van het leven als huisarts-onderzoeker. Familie en vrienden, veel dank voor de interesse die jullie gedurende het hele traject steeds hebben getoond in mijn werk. Dank voor de manier waarop jullie hebben meegeleefd door de successen mee te vieren en bij tegenvallers een luisterend oor te bieden. Pa en ma, de manier waarop jullie in het leven staan: actief, onderzoekend en toegewijd, heeft mij zeker gestimuleerd om aan dit traject te beginnen en het af te maken. Dank voor jullie voorbeeld en jullie betrokkenheid. Arjen, dank voor je onvoorwaardelijke liefde en steun. Dank voor de manier waarop je me motiveert en de ruimte geeft om me te ontwikkelen in mijn vak. Ik hoop dat we nog lang samen mogen optrekken.

4 Curriculum vitae 157 Curriculum vitae Antonette Smelt was born on December in Utrecht, the Netherlands. She attended secondary school at Greijdanus College in Zwolle. In 1998 she started medical school at the University of Groningen where she obtained her medical degree in After this, she worked as a resident at the Department of Pediatrics at Diaconessenhuis Leiden and at the Leiden University Medical Center. The research project described in this thesis was started in March 2008 at the Department of Public Health and Primary Care of the Leiden University Medical Center. Between 2009 and 2012 she completed her vocational training for general practice at the same department. In 2012 she received the annual award for residents in general practice (SBOH Academiseringsprijs) for her study A proactive approach towards migraine in general practice published in the Canadian Medical Association Journal. In that same year she received the Heert Dokterprijs for the best research study published in the national journal for journal practice, Huisarts & Wetenschap. During her research project she also completed her Master of Epidemiology. Between 2012 and 2013 she was part of the committee that revised the guideline Sleeping problems issued by the Dutch College of General Practitioners. At present, she works as a general practitioner in various general practices in Leiden and surrounding areas, and works at the Department of Public Health and Primary Care of the Leiden University Medical Center as a researcher and as a teacher of evidence-based medicine embedded in the vocational training for general practice.

5

6 Bibliography 159 Bibliography Smelt AFH, Thio BJ, Hageman G. Een zuigeling met het syndroom van Horner. Tijdschrift voor Kindergeneeskunde 2006;3: Smelt AFH. Spreekuur! Migraine. Huisarts & Wetenschap 2010;6: Smelt AFH, Weele GM van der, Blom JW, Gussekloo J, Assendelft WJJ. How usual is usual care in pragmatic intervention studies in primary care? - an overview of recent trials. British Journal of General Practice 2010 Jul;60:e Smelt AFH, Blom JW, Dekker F, van den Akker E, Zitman F, Ferrari MD, Assendelft WJJ. A proactive approach towards migraine patients in primary care: a pragmatic randomised controlled trial. Canadian Medical Association Journal 2012;184:E Smelt AFH, Blom JW, Dekker F, van den Akker E, Zitman F, Ferrari MD, Assendelft WJJ. Proactieve benadering van migraine. Huisarts & Wetenschap 2012;55: Smelt AFH, Eijsenga S, Assendelft WJJ, Blom JW. Acceptance of preventive treatment in migraine patients: results of a survey. European Journal of General Practice 2012;18: Smelt AFH, Assendelft WJJ, Terwee CB, Ferrari MD, Blom JW. What is a clinically relevant change on the HIT-6 questionnaire? An estimation in a primary-care population of migraine patients. Cephalalgia 2014;34: Smelt AFH, Assendelft WJJ, Van Dijk CE, Blom JW. Triptan use after starting prophylactic migraine treatment: A retrospective cohort study in a primary care population. Cephalalgia 2014;Feb 12.[Epub ahead of print].

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