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1 Curriculum Vitae
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3 Joachim Jesse Swen was born in Alkmaar, The Netherlands on March 5 th After finishing secondary school (VWO) at the Han Fortmann College in Heerhugowaard in 1996, he started his study Pharmacy at the Utrecht University. In 2002 he obtained his doctoral exam, followed by his PharmD exam, in As part of his doctoral program he worked for nine months on a research project aimed at the development of a model to predict the lymphatic drug transport of testosterone esters. This work was performed at the Department of Pharmaceutics of NV Organon in Oss (supervisors Prof. dr. H. Vromans, Dr. W.A. Faassen). From May 2004 to January 2006, he was involved in the implementation of PeopleSoft ERP software in the Department of Clinical Pharmacy & Toxicology of the Leiden University Medical Center. In 2006 he started his training as clinical pharmacist which was completed in September 2011 (supervisor Prof. dr. H-J Guchelaar). At the same time he started working on the studies presented in this PhD thesis (supervisors Prof. dr. H-J Guchelaar, Prof. dr. W.J.J. Assendelft, Dr. J.A.M. Wessels). As part of his PhD project he joined the Helix group at the Department of Genetics, Stanford University, Palo Alto, CA, USA, for a period of three months in the fall of 2011 (supervisor Prof. dr. R. Altman). After completion of his PhD project he will continue his career as clinical researcher / pharmacist in the field of pharmacogenetics at the Leiden University Medical Center. Jesse Swen lives in Amsterdam and is married to Charlotte Gubbels. curriculum vitae 207
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5 List of Publications
6 THIS THESIS Swen JJ, Huizinga TW, Gelderblom H et al. Translating pharmacogenomics: challenges on the road to the clinic. PLoS Med 2007;4(8):e209. Swen JJ, Wilting I, de Goede AL et al. Pharmacogenetics: from bench to byte. Clin Pharmacol Ther 2008;83(5): Van der Straaten T, Swen J, Baak-Pablo R, Guchelaar HJ. Use of plasmid-derived external quality control samples in pharmacogenetic testing. Pharmacogenomics 2008;9(9): Swen JJ, Wessels JA, Krabben A, Assendelft WJ, Guchelaar HJ. Effect of CYP2C9 polymorphisms on prescribed dose and time-to-stable dose of sulfonylureas in primary care patients with Type 2 diabetes mellitus. Pharmacogenomics 2010;11(11): Swen JJ, Nijenhuis M, de Boer A et al. Pharmacogenetics: from bench to byte- an update of guidelines. Clin Pharmacol Ther 2011;89(5): Swen JJ, Guchelaar HJ, Baak-Pablo RF, Assendelft WJ, Wessels JA. Genetic risk factors for type 2 diabetes mellitus and response to sulfonylurea treatment. Pharmacogenet Genomics 2011;21(8): Swen JJ, Van der Straaten T, Wessels JA et al. Feasibility of pharmacy initiated pharmacogenetic screening for CYP2D6 and CYP2C19. Eur J Clin Pharmacol (in press). Swen JJ, Baak-Pablo RF, Guchelaar H-J, van der Straaten T. Alternative methods to a Taq- Man assay to detect a tri-allelic SNP in the HNF1B gene. Clin Chem Lab Med (in press). RELATED TO THIS THESIS Swen JJ, Wessels JA, Guchelaar HJ. Farmacogenetica: van abstract begrip naar klinische praktijk. Geneesmiddelenbulletin 2010;44(9): (article in Dutch). Wilffert B, Swen J, Mulder H et al. From evidence based medicine to mechanism based medicine. Reviewing the role of pharmacogenetics. Int J Clin Pharm 2011;33(1):3-9. Swen JJ, Guchelaar HJ. Comment: global formulary review: how do we integrate pharmacogenomic information? Ann Pharmacother 2011;45(7-8):1030. Opdam FL, Swen JJ, Wessels JA, Gelderblom H. Letter: SNPs and Haplotypes in DPYD and Outcome of Capecitabine. Clin Cancer Res 2011;17(17): Swen JJ, Guchelaar HJ. Pharmacogenetic dose recommendations in clinical practice. EJHP (in press). 210
7 OTHER Van der Molen H, de Raadt W, Swen JJ. Van specifiek naar algemeen. ERP in het LUMC. ICTzorg 2007;2(8):10-12 (article in Dutch). Swen JJ, Krens L, Ten Brink MH. Een uur leven kost maximaal 9 euro 13. NRC Next 2010 February 15, Opinion section: (article in Dutch). Nijkeuter M, Huidekoper AL, Swen JJ. An autointoxication with nutmeg. Wetenschappelijk Platform Pharmaceutisch Weekblad 2011;4(5):65-67 (article in Dutch). list of publications 211
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9 Nawoord
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11 Onderzoek kan je letterlijk en figuurlijk ver brengen; terwijl ik dit schrijf zit ik circa km van Nederland in de Californische oktoberzon. De totstandkoming van dit proefschrift laat zich vergelijken met een klein sneeuwvlokje dat in december 2004 op de top van een berg terecht kwam en in de jaren daarna al naar beneden rollend steeds in omvang is toegenomen. Op de tocht naar beneden zijn er vele splitsingen gepasseerd, waarbij vooraf niet altijd duidelijk was waar we aan de voet van de berg uit zouden gaan komen. Onderweg was de helling soms zo vlak, dat er, om te blijven rollen, een duwtje nodig was. Graag wil ik iedereen die hier aan heeft bijgedragen bedanken. In het bijzonder bedank ik de patiënten en huisartsen die bereid zijn geweest mee te werken aan de klinische onderzoeken. Ook de leden van de farmacogenetica werkgroep ben ik veel dank verschuldigd. Verder wil ik graag Evelyn Vlassak en Annemarie Krabben bedanken. Zij hebben met hun afstudeeronderzoek een geweldige bijdrage aan de hoofdstukken 4 en 7 geleverd. Naast onderzoek stonden de afgelopen jaren ook in het teken van de opleiding tot ziekenhuisapotheker. Graag wil ik al mijn KFT collega s bedanken die hier aan hebben bijgedragen. Mijn (oud)kamergenoten Judith, Marloes, Mathieu, Rogier, Jan, Wouter, Arjen, Els, Dirk Jan, Lisanne, Nielka, Aniko en Louise zorgden in deze periode (bijna) altijd voor een goede sfeer en samenwerking. Waarde paranimfen, jullie zijn op twee totaal verschillende manieren bij dit proefschrift betrokken. Beste Arjan, jij stond aan de basis in Utrecht en zoals algemeen bekend is een goed begin het halve werk! Beste Marloes, ik waardeer enorm de goede discussies die we over werk, maar ook over andere onderwerpen hebben. Daarnaast is jouw sport-fanatisme een goede bron van inspiratie. Lieve familie, geweldig dat we allemaal in Amsterdam wonen (en dat Amsterdam zo groot is dat we elkaar toch niet dagelijks tegen het lijf lopen). Dank voor alle leuke dingen die we samen gedaan hebben en ongetwijfeld nog gaan doen. Lieve ouders, dank voor jullie onuitputtelijke steun. Lieve, lieve Cleo, sommige dingen zijn niet in woorden te vatten... Nawoord 215
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Cover Page. The handle http://hdl.handle.net/1887/33832 holds various files of this Leiden University dissertation
Cover Page The handle http://hdl.handle.net/1887/33832 holds various files of this Leiden University dissertation Author: Krens, Lisanne Title: Refining EGFR-monoclonal antibody treatment in colorectal
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Cover Page The handle http://hdl.handle.net/1887/28461 holds various files of this Leiden University dissertation. Author: Brink, Marloes Hendrika ten Title: Individualized therapeutics in allogeneic stem
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Cover Page The handle http://hdl.handle.net/1887/44921 holds various files of this Leiden University dissertation Author: Aa, Marloes van der Title: Diagnosis and treatment of obese children with insulin
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Cover Page The handle http://hdl.handle.net/1887/33676 holds various files of this Leiden University dissertation. Author: Huis-Tanja, Lieke Henriëtte van Title: Pharmacogenetics of capecitabine and oxaliplatin
Nadere informatiePublications PUBLICATIONS
Publications 164 Publications PUBLICATIONS 1. Heemskerk B, Veltrop-Duits LA, van Vreeswijk T, ten Dam MM, Heidt S, Toes RE, van Tol MJ, Schilham MW. Extensive cross-reactivity of CD4 + adenovirus-specific
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Nadere informatiePièrre Bet en alle medewerkers van de centrale apotheek wil ik danken voor het bereiden en verstrekken van de onderzoeksmedicatie.
Dit proefschrift is tot stand gekomen met de hulp van vele mensen die ik graag zou willen bedanken. Allereerst wil ik de patiënten heel erg danken voor hun deelname aan de verschillende studies. Uw medewerking
Nadere informatieCitation for published version (APA): Faber, A. (2006). Stimulant treatment in children: A Dutch perspective s.n.
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Nadere informatieCurriculum Vitae. Personal information. Diploma s. Languages. Internships. Working experience. Christophe Lemmens
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