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1 Cover Page The handle holds various files of this Leiden University dissertation. Author: Berg, C.W. van den Title: State of the heart : the promise of pluripotent stem cell-derived cardiomyocytes in disease modelling, differentiation and development Issue Date:
2 CHAPTER Dankwoord 10
3 Chapter
4 Dankwoord raag wil ik op deze plaats iedereen bedanken die een bijdrage heeft geleverd aan het tot stand komen van dit proefschrift. Prof. dr. C.L. Mummery, promotor. Beste Christine, bedankt voor de kansen die je mij hebt geboden tijdens mijn promotieonderzoek in jouw laboratorium. Jouw visie, enthousiasme en passie voor de wetenschap zijn inspirerend! Je snelle feedback op manuscripten en je onmisbare kennis op het gebied van stamcellen en cardiomyocyten zijn bijzonder waardevol. Dr. R.P. Davis, co-promotor. Dear Richard, thank you for your confidence and the fantastic way in which you have guided and educated me to become a stem cell researcher. Together we formed an excellent scientific team: we could almost guess what the other was thinking. It was great to learn from someone with so much theoretical and practical expertise. Prof. dr. Douwe Atsma, Prof. dr. Connie Bezzina, Prof. dr. Vincent Christoffels, Prof. dr. Marie José Goumans en Prof. dr. Robert Passier ben ik zeer erkentelijk voor het plaatsnemen in de leescommissie en het beoordelen van mijn proefschrift. Graag wil ik alle co-auteurs bedanken voor hun bijdrage aan de manuscripten. Speciale dank gaat uit naar alle collega s van de afdeling Anatomie en Embryologie. Dank jullie wel voor de samenwerking en de geweldige tijd tijdens mijn promotieonderzoek. Het was een voorrecht om in zo n internationale groep te werken. Vriend(inn)en en kennissen, dank voor de gezelligheid in de periode van mijn promotieonderzoek. Fijn om naast het pipetteren en schrijven te ontspannen met een etentje, een stedentrip, museumbezoek of genieten in de natuur. Graag wil ik mijn familie bedanken voor hun interesse in mijn promotieonderzoek. Dank je wel voor jullie onvoorwaardelijke steun, luisterend oor, begrip, betrokkenheid, liefde en goede raad
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6 CHAPTER Curriculum vitae 11
7 Chapter
8 Curriculum Vitae Cathelijne Willemijne van den Berg was born on May 11th, 1986 in Rotterdam, the Netherlands. She graduated from the gymnasium at CSG Johannes Calvijn in Rotterdam in She wanted to gain a thorough understanding of human health and disease and started her studies Biomedical Sciences at the Leiden University Medical Center in Leiden. During her Master she performed her first internship about the Regulation of Innate responsiveness in the Intestine under the supervision of Prof. Edward Nieuwenhuis, MD, PhD (department of Paediatrics, Erasmus Medical Center, Rotterdam). She moved to the Karolinska Institutet (Stockholm, Sweden) for an exchange program about Molecular Methods in Drug Development, followed by the course Science Based Business Fundamentals at the Faculty of Science (Leiden University). She was fascinated by the field of stem cell biology and performed her final internship in the laboratory of Prof. Christine Mummery, PhD (department of Anatomy and Embryology, the Leiden University Medical Center). She was supervised by Richard Davis, PhD and worked on mouse pluripotent stem cell models of a human cardiac sodium channelopathy. She received her Master s degree in 2010 and continued to work in the same laboratory as a PhD-candidate. In 2012 she was awarded the Beverly McKinnell Honorable Mention Award by the International Society of Differentiation at the conference Stem Cells, Development and Regulation in Amsterdam. The results of the research are presented in this thesis. In 2015 she started as a postdoctoral researcher in the laboratory of Prof. Ton Rabelink, MD, PhD (department of Nephrology, Leiden University Medical Center) to work on the generation of kidney organoids from pluripotent stem cells. In 2016 she received the Wiyadharma Fellowship for her research to develop a clinical application for patients with kidney failure
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10 CHAPTER List of publications 12
11 Chapter
12 List of publications Journal publications Cathelijne W. van den Berg*, Richard P. Davis*, Simona Casini, Stefan R. Braam, Christine L. Mummery Pluripotent stem cell models of cardiac disease and their implication for drug discovery and development. Trends in Molecular Medicine 17, (2011) Cathelijne W. van den Berg*, Richard P. Davis*, Simona Casini*, Maaike Hoekstra, Carol Ann Remme, Cheryl Dambrot, Daniela Salvatori, Dorien Ward-van Oostwaard, Arthur A.M. Wilde, Connie R. Bezzina, Arie O. Verkerk, Christian Freund, Christine L. Mummery, PhD Cardiomyocytes derived from pluripotent stem cells recapitulate electrophysiological characteristics of an overlap syndrome of cardiac sodium channel disease. Circulation 125, (2012) Cathelijne W. van den Berg, Satoshi Okawa, Susana M. Chuva de Sousa Lopes, Liesbeth van Iperen, Robert Passier, Stefan R. Braam, Leon Tertoolen, Antonio del Sol, Richard P. Davis, Christine L. Mummery Transcriptome of human foetal heart compared with cardiomyocytes from pluripotent stem cells. Development 142, (2015) Textbook publications Cheryl Dambrot, Cathelijne W. van den Berg, Dorien Ward-van Oostwaard, Richard P. Davis, Stefan R. Braam, Elizabeth Ng, Christine L. Mummery Cardiomyocyte Differentiation of Human Pluripotent Stem Cells. Human Stem Cell Manual Second Edition, (2012) Cathelijne W. van den Berg, David A. Elliott, Stefan R. Braam, Christine L. Mummery, Richard P. Davis Differentiation of Human Pluripotent Stem Cells to Cardiomyocytes Under Defined Conditions. Patient-Specific Induced Pluripotent Stem Cell Models - Generation and Characterization Series: Methods in Molecular Biology 1353, (2016) Scientific Awards 2012: Beverly McKinnell Honorable Mention Award by the International Society of Differentiation *, These authors contributed equally
Cover Page. The handle holds various files of this Leiden University dissertation
Cover Page The handle http://hdl.handle.net/1887/22989 holds various files of this Leiden University dissertation Author: Pouw, Lucinda Title: Emotion regulation in children with Autism Spectrum Disorder
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Cover Page The handle http://hdl.handle.net/1887/20223 holds various files of this Leiden University dissertation. Author: Spijker, Anne Titia Title: Cortisol exposure, cognition and clinical course of
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Cover Page The handle http://hdl.handle.net/1887/37815 holds various files of this Leiden University dissertation. Author: Kleibeuker, Sietske Willemijn Title: 'What Box?': behavioral, neuro-imaging, and
Cover Page. The handle http://hdl.handle.net/1887/33187 holds various files of this Leiden University dissertation
Cover Page The handle http://hdl.handle.net/1887/33187 holds various files of this Leiden University dissertation Author: Hidding, Elske Title: Neurocognitive mechanisms and vulnerability to autism and
Exploiting natural and induced genetic variation to study hematopoiesis Gerrits, Alice
Exploiting natural and induced genetic variation to study hematopoiesis Gerrits, Alice IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it.
Publications PUBLICATIONS
Publications 164 Publications PUBLICATIONS 1. Heemskerk B, Veltrop-Duits LA, van Vreeswijk T, ten Dam MM, Heidt S, Toes RE, van Tol MJ, Schilham MW. Extensive cross-reactivity of CD4 + adenovirus-specific
Cover Page. Author: Aa, Marloes van der Title: Diagnosis and treatment of obese children with insulin resistance Issue Date:
Cover Page The handle http://hdl.handle.net/1887/44921 holds various files of this Leiden University dissertation Author: Aa, Marloes van der Title: Diagnosis and treatment of obese children with insulin
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Cover Page The handle http://hdl.handle.net/1887/35006 holds various files of this Leiden University dissertation. Author: Pasma, Jantsje Henrieke Title: Impaired standing balance : unraveling the underlying
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Cover Page The handle http://hdl.handle.net/1887/18691 holds various files of this Leiden University dissertation. Author: Jong, Kim de Title: A chance for change : building an outcome monitoring feedback
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Cover Page The handle http://hdl.handle.net/1887/37530 holds various files of this Leiden University dissertation. Author: Nielen, Thijs Martinus Johannes Title: Aliteracy : causes and solutions Issue
Cover Page. Author: Meijer, Eline Title: This is [not] who I am : understanding identity in continued smoking and smoking cessation Date:
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Cover Page The handle http://hdl.handle.net/1887/57383 holds various files of this Leiden University dissertation Author: Meijer, Eline Title: This is [not] who I am : understanding identity in continued
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Cover Page The handle http://hdl.handle.net// holds various files of this Leiden University dissertation. Author: Verbiest, Marjolein Elisabeth Anna Title: The implementation of smoking cessation care
Citation for published version (APA): Crane, L. M. A. (2011). Intraoperative fluorescence imaging in cancer Groningen: s.n.
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Acknowledgement. Acknowledgement
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Cover Page The handle http://hdl.handle.net/1887/38841 holds various files of this Leiden University dissertation Author: Bie, Jasper L. de Title: How jihadist networks operate : a grounded understanding
DANKWOORD Dit proefschrift is het resultaat van een proces waar velen bij betrokken zijn geweest. Tot een aantal mensen wil ik in het bijzonder het wo
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Cover Page. The handle holds various files of this Leiden University dissertation
Cover Page The handle http://hdl.handle.net/1887/23005 holds various files of this Leiden University dissertation Author: Stoutjesdijk, Regina Title: Children with emotional and behavioral disorders in
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SUPPLEMENT 1 DANKWOORD
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Cover Page The handle http://hdl.handle.net/1887/47238 holds various files of this Leiden University dissertation Author: Philipsen, Cheryl Title: Unraveling the auxin mechanism in 2,4-D induced somatic
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Cover Page The handle http://hdl.handle.net/1887/28971 holds various files of this Leiden University dissertation Author: Rosalia, Rodney Alexander Title: Particulate based vaccines for cancer immunotherapy
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Cover Page The handle http://hdl.handle.net/1887/43530 holds various files of this Leiden University dissertation. Author: Stijntjes, M. Title: Interactions of cognitive and physical ageing Issue Date:
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Cover Page The handle http://hdl.handle.net/1887/33832 holds various files of this Leiden University dissertation Author: Krens, Lisanne Title: Refining EGFR-monoclonal antibody treatment in colorectal
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Cover Page. Author: Gennip, Anna Eva (Nanine) van Title: Assessing together. Peer assessment from an interpersonal perspective Issue Date:
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Dankwoord & Curriculum Vitae
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Cover Page. Author: Smelt, Antonette Title: Treatment of migraine : from clinical trial to general practice Issue Date: 2014-05-14
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Cover Page The handle http://hdl.handle.net/1887/36475 holds various files of this Leiden University dissertation. Author: Windhorst, Dina Aafje (Dafna) Title: Differential susceptibility to parenting
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Cover Page The handle http://hdl.handle.net/1887/36998 holds various files of this Leiden University dissertation. Author: Dunnen, Angela den Title: Surface-structure dependencies in catalytic reactions
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Cover Page The handle http://hdl.handle.net/1887/66118 holds various files of this Leiden University dissertation. Author: Duijn, S. van Title: MRI and histologic studies on early markers of Alzheimer's
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Cover Page The handle http://hdl.handle.net/1887/31604 holds various files of this Leiden University dissertation Author: Kolfschoten, N.E. Title: Measuring quality of care for colorectal cancer care :
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Cover Page The handle http://hdl.handle.net/1887/43954 holds various files of this Leiden University dissertation. Author: Soenen, S.M.T.A. Title: Mild intellectual disability : an entity? Mapping clinical
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Cover Page The handle http://hdl.handle.net/1887/24378 holds various files of this Leiden University dissertation. Author: Melief, Sara Marie Title: Immunomodulatory properties of human multipotent stromal
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Cover Page The handle http://hdl.handle.net/1887/74052 holds various files of this Leiden University dissertation. Author: Winder, J.Y. Title: The UHDRS and UHDRS-FAP assessments in Huntington's disease
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Dankwoord 206 Dankwoord Ik durf het bijna niet te zeggen, het is af Vier jaar promoveren is voorbij gevlogen en dit is het resultaat. Ik zal de afgelopen vier jaren herinneren als een ontzettend leuke
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Cover Page The handle http://hdl.handle.net/1887/45043 holds various files of this Leiden University dissertation. Author: Plak, R.D. Title: What works for whom? Differential genetic effects of early literacy
Cover Page. Author: Liem-Moolenaar, Marieke Title: Human pharmacology of current and new treatments for schizophrenia Issue Date:
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Pièrre Bet en alle medewerkers van de centrale apotheek wil ik danken voor het bereiden en verstrekken van de onderzoeksmedicatie.
Dit proefschrift is tot stand gekomen met de hulp van vele mensen die ik graag zou willen bedanken. Allereerst wil ik de patiënten heel erg danken voor hun deelname aan de verschillende studies. Uw medewerking
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