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1 Cover Page The handle holds various files of this Leiden University dissertation. Author: Commandeur, Suzan Title: Organotypic in vitro models of human cutaneous squamous cell carcinoma Issue Date:

2 Chapter List of publications van Doorn R, Zoutman WH, Dijkman R, de Menezes RX, Commandeur S, Mulder AA, van der Velden PA, Vermeer MH, Willemze R, Yan PS, Huang TH, Tensen CP. Epigenetic profiling of cutaneous T cell lymphoma: promoter hypermethylation of multiple tumor suppressor genes including BCL7a, PTPRG, and p73. J Clin Oncol Jun 10;23(17): Commandeur S, van Beusekom HM, van der Giessen WJ. Polymers, drug release, and drug eluting stents. J Interv Cardiol Dec;19(6): Review. Michiels JJ, Commandeur S, Hoogenboom GJ, Wegman JJ, Scholten L, van Rijssel RH, De Raeve H. JAK2(V617F) positive early stage myeloproliferative disease (essential thrombocythemia) as the cause of portal vein thrombosis in two middle aged women: therapeutic implications in view of the literature. Ann Hematol Nov;6(11): Review. El Ghalbzouri A, Commandeur S, Rietveld MH, Mulder AA, Willemze R. Replacement of animal derived collagen matrix by human fibroblast derived dermal matrix for human skin equivalent products. Biomaterials Jan;30(1):71. Commandeur S, de Gruijl FR, Willemze R, Tensen CP, El Ghalbzouri A. An in vitro threedimensional model of primary human cutaneous squamous cell carcinoma. Exp Dermatol Oct;1(10): El Ghalbzouri A, Commandeur S. In vitro disease models: human skin equivalents for research purposes. ALTEX 27; 2010 special issue: Commandeur S, Ho SH, De Gruijl FR, Willemze R, Tensen CP, El Ghalbzouri A. Functional characterization of cancer associated fibroblasts of human cutaneous squamous cell carcinoma. Exp Dermatol Sep;20(9): Commandeur S, Van Drongelen V, De Gruijl FR, Willemze R, El Ghalbzouri A. Epidermal growth factor receptor activation and inhibition in 3D in vitro models of normal skin and human cutaneous squamous cell carcinoma in vitro. Cancer Science (accepted). 170

3 List of publications Hameetman L, Commandeur S, Bouwes Bavinck JN, Wisgerhof HC, De Gruijl FR, Willemze R, Mullenders L, Tensen CP, Vrieling H. Gene expression analysis of squamous cell carcinoma of immunosuppressed transplant recipients. Submitted. Emanuel RM, Dueck AC, Geyer HL, Kiladjian JJ, Slot S, Zweegman S, Te Boekhorst PA, Commandeur S, Schouten HC, Sackmann F, Kerguelen Fuentes A, Hernández Maraver D, Pahl HL, Griesshammer M, Stegelmann F, Doehner K, Lehmann T, Bonatz K, Reiter A, Boyer F, Etienne G, Ianotto JC, Ranta D, Roy L, Cahn JY, Harrison CN, Radia D, Muxi P, Maldonado N, Besses C, Cervantes F, Johansson PL, Barbui T, Barosi G, Vannucchi AM, Passamonti F, Andreasson B, Ferarri ML, Rambaldi A, Samuelsson J, Birgegard G, Tefferi A, Mesa RA. Myeloproliferative Neoplasm (MPN) Symptom Assessment Form Total Symptom Score: Prospective International Assessment of an Abbreviated Symptom Burden Scoring System Among Patients With MPNs. J Clin Oncol Oct

4 Chapter Curriculum vitae Suzan Commandeur werd geboren op 1 februari 193 te Delft. Zij groeide op in Naaldwijk en Maassluis en volgde het voorbereidend wetenschappelijk onderwijs (vwo) aan het CSG Aquamarijn te Vlaardingen. Na het behalen van het eindexamen atheneum in 2001, begon zij in datzelfde jaar aan de bacheloropleiding Life Science & Technology aan de Technische Universiteit Delft en de Universiteit Leiden. Ter afsluiting van deze opleiding liep zij stage bij de afdeling Dermatologie van het Leids Universitair Medisch Centrum (LUMC) en deed daar onderzoek naar DNA methylatie in cutane T cel lymfomen onder leiding van Dr. Remco van Doorn. Zij vervolgende het Life Science & Technology opleidingstraject in 2003 met de gelijknamige masteropleiding. Ter afsluiting van deze opleiding liep zij een onderzoeksstage bij de afdeling Experimentele Cardiologie in het Erasmus MC te Rotterdam onder leiding van Dr. Heleen van Beusekom. Hier deed zij onderzoek naar regeneratie van menselijke hartcellen met biodegradeerbare, injecteerbare biomaterialen. In het kader van ditzelfde onderzoek liep zij een bedrijfsstage bij de afdeling Business Development van OctoPlus B.V. in Leiden onder leiding van Gerben Moolhuizen MBA, waar ze de marktaspecten van biodegradeerbare microsferen voor hartregeneratie onderzocht in een business case. In 2006 studeerde zij cum laude af aan de masteropleiding Life Science & Technology met een specialisatie in functional genomics. In 2006 startte zij met het in dit proefschrift beschreven promotieonderzoek naar de ontwikkeling van een in vitro huidkankermodel aan de afdeling Dermatologie van het LUMC onder leiding van Dr. Abdoel El Ghalbzouri, Dr. Frank de Gruijl, Dr. Kees Tensen en Prof. Dr. Rein Willemze. Dit promotieonderzoek werd in 2009 bekroond tot ZonMw Parelproject. Gedurende haar promotieonderzoek begeleidde zij drie studenten Biomedische Wetenschappen bij hun afstudeerstages. In deze periode bouwde zij tevens een netwerk op van contacten bij belangenorganisaties in het veld van alternatieven voor dierproeven. Daarnaast deed zij gedurende een jaar onderzoek naar huidmelanomen onder leiding van Dr. Nelleke Gruis. In die periode begeleidde ze een student Biomedische Wetenschappen bij de ontwikkeling van een in vitro model voor huidmelanomen. Tenslotte heeft zij zich tijdens haar promotieonderzoek samen met haar co promotor Dr. Abdoel El Ghalbzouri gericht op de commercialisering van in vitro huidmodellen door deelname aan de Venture Challenge van het Netherlands Genomics Initiative (NGI) in Vanaf 2011 werkte zij als operational manager op een NGI Life Sciences Pre Seed Grant aan de verdere commerciële toepassing van in vitro huidmodellen binnen de afdeling Dermatologie van het LUMC te Leiden. Momenteel is zij in dienst bij Aeon Astron Europe B.V. als senior product specialist human skin equivalents om commercialisering van 172

5 Curriculum vitae de Leidse in vitro huidmodellen, waaronder de in dit proefschrift beschreven in vitro huidkankermodellen, concreet uit te bouwen in nauwe samenwerking met de afdeling Dermatologie van het LUMC. Naast haar opleiding en promotieonderzoek is Suzan sinds 2003 actief als vrijwilliger en later bestuurslid informatievoorziening bij de MPN Stichting; de Nederlandse patiëntenorganisatie voor mensen met de myeloproliferatieve neoplasieën (MPN) essentiële trombocytemie, polycythaemia vera en myelofibrose. 173

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