MEDISCHE FOTONICA. Arjen Amelink. TNO Optics. VU Biophotonics & Medical Imaging

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Alfred van der Woude
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1 MEDISCHE FOTONICA Arjen Amelink TNO Optics VU Biophotonics & Medical Imaging

allemaal ouder worden met meerdere chronische ziekten.

2 MAATSCHAPPELIJK UITDAGING: GEZONDHEID EN ZORG Zorgvraag stijgt snel, door onze suboptimale leefstijl en doordat we allemaal ouder worden met meerdere chronische ziekten. De betaalbaarheid van de zorg staat hierdoor toenemend onder druk

3 NATIONALE AGENDA FOTONICA Preventie, screening en vroege detectie van ziekten Betere diagnose en monitoring voor geïndividualiseerde behandeling

MEDISCHE FOTONICA @ TNO Preventie, screening en vroege detectie van

4 MEDISCHE TNO Preventie, screening en vroege detectie van ziekten Betere diagnose en monitoring voor geïndividualiseerde behandeling

5 KANKER SCREENING MET LICHT

6 LIGHT-TISSUE INTERACTIONS

$LIGHT-TISSUE INTERACTIONS SCATTERING Photons scatter (change direction) in tissue due to fluctuations in the optical refractive$

7 LIGHT-TISSUE INTERACTIONS SCATTERING Photons scatter (change direction) in tissue due to fluctuations in the optical refractive index that occur on size scales ranging from a few nanometers to a few millimeters. Light scattering contains structural information

8 LIGHT-TISSUE INTERACTIONS ABSORPTION Absorbing molecules in tissue: oxyhemoglobin deoxyhemoglobin melanin bilirubin beta-carotene Light absorption contains physiological and molecular information Concentrations of absorbing molecules can be determined using spectroscopy

device, low-cost, minimallyinvasive technology d fib Quantification of

9 MEASUREMENT OF OPTICAL PROPERTIES Illumination and detection using fibers Thin and flexible probe, can be easily guided through thin needles Simple device, low-cost, minimallyinvasive technology d fib Quantification of absorption and scattering in tissue related to physiology and morphology of tissue

10 MEASUREMENT OF OPTICAL PROPERTIES NIR

11 MEASUREMENT OF OPTICAL PROPERTIES NIR

12 MEASUREMENT OF OPTICAL PROPERTIES NIR

13 KANKER SCREENING MET LICHT quantify vascular properties of tissue by measuring the absorption coefficient quantify structural properties of tissue by measuring the scattering properties

CLINICAL PILOT STUDY @ ERASMUS MC KWF Alpe d Huzes unique opportunities grant high risk, high gain research with Erasmus MC.

14 CLINICAL PILOT ERASMUS MC KWF Alpe d Huzes unique opportunities grant high risk, high gain research with Erasmus MC. Measurements performed on buccal mucosa (cheek) of patients with distant (laryngeal) H&N cancer and controls (smokers without cancer).

15 MEDISCHE TNO Preventie, screening en vroege detectie van ziekten Betere diagnose en monitoring voor geïndividualiseerde behandeling

This facilitates early detection and monitoring of systemic diseases noninvasively,

16 RETINAL IMAGING: EYE AS WINDOW TO YOUR HEALTH Vision The retina is a metabolically active tissue with visual access to the vascular and central nervous systems. This facilitates early detection and monitoring of systemic diseases noninvasively, enabling earlier, better and more personalized treatment while reducing health care costs. 16 Retinal Imaging

PRIMARY EYE HEALTH CARE Development of a fundus camera that enables primary eye health care Low-cost Hand-held Easy to use Non-mydriatic Image quality not the best, but sufficient Computer

17 PRIMARY EYE HEALTH CARE Development of a fundus camera that enables primary eye health care Low-cost Hand-held Easy to use Non-mydriatic Image quality not the best, but sufficient Computer assisted diagnosis The products aims to; provide for access to eye screening worldwide provide patients with eye screening during their diabetes health check at their general practitioner (GP) Fase 1

interactions Structural information from scattering Physiological and molecular

18 GETTING MORE INFORMATION FROM A FUNDUS CAMERA Aim: not better (higher resolution) image, but extract more information from fundus image based on light tissue interactions Structural information from scattering Physiological and molecular information from absorption + Monte Carlo simulations of light transport in retinal tissue

19 MEDISCHE TNO Preventie, screening en vroege detectie van ziekten Betere diagnose en monitoring voor geïndividualiseerde behandeling

SELECTIVE ION MEASUREMENT FOR HEAMODIALYSIS Increase the quality of clinical dialysis treatments Increase quality of life for patients by personalized treatment Decrease hospitalisations due to

20 SELECTIVE ION MEASUREMENT FOR HEAMODIALYSIS Increase the quality of clinical dialysis treatments Increase quality of life for patients by personalized treatment Decrease hospitalisations due to side-effects Clinical dialysis Enabler for sorbent technology in portable kidney machines Use less dialysate by reusing dialysate with sorbent technology Enabling home dialysis, every night By measuring the ion concentrations in (reused) dialysate Portable Artificial Kidney

21 LASER INDUCED BREAKDOWN SPECTROSCOPY Plasma Na + K + Ca Selective ion and molecule measurement for dialysis 23 May 2017

22 MINIATURE LIBS SENSOR Array detector Monolithic injection mouldable spectrometer Grating 30 mm pulsed LIBS laser Cuvette can be a detachable disposable - Single optical component - Tailored for Na, K, Ca - Low-cost fabrication

23 MEDISCHE TNO Preventie, screening en vroege detectie van ziekten Betere diagnose en monitoring voor geïndividualiseerde behandeling

24 THANK YOU FOR YOUR ATTENTION Voor meer inspiratie: TIME.TNO.NL

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