Tinnitus Bartels, Hilke
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- Joannes van der Wal
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1 Tinnitus Bartels, Hilke IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below. Document Version Publisher's PDF, also known as Version of record Publication date: 2008 Link to publication in University of Groningen/UMCG research database Citation for published version (APA): Bartels, H. (2008). Tinnitus: new insights into pathophysiology, diagnosis and treatment University of Groningen Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons). Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Downloaded from the University of Groningen/UMCG research database (Pure): For technical reasons the number of authors shown on this cover page is limited to 10 maximum. Download date:
2 Tinnitus new insights into pathophysiology, diagnosis and treatment
3 ISBN: Cover design: Kakelfonie, door Nol Reuser Acryl op doek, 80x100 cm Printed by Ponsen & Looijen b.v by H.Bartels. All rights reserved. No parts of this book may be reproduced or transmitted in any form or by any means without the permission of the author. II
4 Tinnitus new insights into pathophysiology, diagnosis and treatment Proefschrift ter verkrijging van het doctoraat in de Medische Wetenschappen aan de Rijksuniversiteit Groningen op gezag van de Rector Magnificus, dr. F. Zwarts, in het openbaar te verdedigen op woensdag 26 november 2008 om 14:45 uur door Hilke Bartels geboren op 20 februari 1978 te Nijmegen III
5 Promotores: Prof.dr. F.W.J. Albers (postuum) Prof.dr. M.J. Staal Prof.dr. B.F.A.M. van der Laan Copromotor: Dr. L.J. Middel Beoordelingscommissie: Prof.dr. P. van Dijk Prof.dr. K. van der Meer Prof.dr. J.J.A. Mooij IV
6 Ik heb een steen verlegd, in een rivier op aarde. Het water gaat er anders dan voorheen. De stroom van een rivier, hou je niet tegen het water vindt er altijd een weg omheen. Misschien eens gevuld, door sneeuw en regen, neemt de rivier m'n kiezel met zich mee. Om hem, dan glad, en rond gesleten, te laten rusten in de luwte van de zee. Ik heb een steen verlegd, in een rivier op aarde. Nu weet ik dat ik nooit zal zijn vergeten. Ik leverde bewijs van mijn bestaan. Omdat, door het verleggen van die ene steen, de stroom nooit meer dezelfde weg zal gaan. Bram Vermeulen Aan professor F.W.J. Albers V
7 VI
8 Contents General introduction and outline of the thesis 9 Chapter 1. Tinnitus and neural plasticity of the brain 19 Chapter 2. Clinical evaluation of chronic, subjective tinnitus 35 Chapter 3. Results of clinical evaluation of 105 and questionnaire 55 evaluation of 265 help-seeking chronic tinnitus sufferers Chapter 4. The distressed (Type D) personality is independently 69 associated with tinnitus adjusted for other personality characteristics: a case-control study Chapter 5. The impact of Type D personality on health-related 87 quality of life and disease severity in chronic tinnitus patients is largely mediated by psychological distress Chapter 6. The additive effect of co-occurring anxiety and depression 107 on health status, quality of life and coping strategies in help-seeking tinnitus patients Chapter 7. Long-term evaluation of treatment of chronic, 127 therapeutically refractory tinnitus with neurostimulation of the vestibulocochlear nerve Chapter 8. Quantifying and modulating tinnitus using neuroimaging 141 techniques and transcranial magnetic stimulation (TMS) Chapter 9. General conclusions, discussion and future perspectives 159 VII
9 Summary 171 Nederlandse samenvatting 177 Dankwoord 185 Curriculum Vitae 189 List of publications 191 VIII
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