VOORJAAR mei Directie INstruchemie BV Irenus Nieland Fons Nieland Vernieuwde website 2008

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1 Terugblik - VOORJAAR mei Terugblik Inhoudsopgave Geachte lezer(es), Pagina 1 Voorwoord en voorjaar Voor U ligt het 1 voorjaarsnummer van INstruendum. Met een uitgifte van 4 stuks per jaar zullen wij U op de hoogte houden van actuele zaken, producten en diensten van INstruchemie. Naast eigen productie hebben wij met ca. 30 internationale bestaande en nieuwe fabrikanten meerjarige distributieovereenkomsten afgesloten en goede prijsafspraken kunnen maken. Successievelijk zullen wij U via INstruendum, mailings en internet informeren over diverse actuele items. Pagina 2 Webpagina producten. Pagina 3 INstruchemie producten. Pagina 4 Aptec Diagnostics: Immunoturbidimetry. Pagina 5, 6, 7 KOVA systeem: Standaardisatie urine onderzoek. Stabilur tabletten. Pagina 7 Bezinkingscontroles. Pagina 8 Niche bepalingen. Pagina 9 Enkele leveranciers. Pagina 10 Aanvraagformulier. e Dit nummer staat in het teken van onze compleet vernieuwde website, enige eigen niche productie en een selectie van partners met interessante producten. Mede dankzij velen van U bestaat INstruchemie in 2009 alweer 30 jaar en daar zijn we U zeer erkentelijk voor. Onze producten worden inmiddels in zo n 40 landen verkocht. Wij hebben de intentie om in Nederland ons marktaandeel te vergroten middels vooral zgn. niche bepalingen, sneltesten, onafhankelijke controles en universeel te gebruiken open vrij programmeerbare kleinere analyseautomaten. Wij hebben inmiddels een zeer groot assortiment met hoogwaardige zorgvuldig geselecteerde diagnostica, biochemicaliën, LIMS software en apparatuur tegen zeer concurrerende prijzen. Uw reacties worden zeer gewaardeerd. Met vriendelijke groet, Directie INstruchemie BV Irenus Nieland Fons Nieland Vernieuwde website 2008 Bio- en windenergie, koolzaad en molens, Noord-Nederland, voorjaar Science without f(r)iction since 1979 ISO 9001 / / CE Chamber of Commerce Groningen Pagina 1 van 10

2 Webpagina producten. Vernieuwde website 2008 Pagina 2 van 10

3 Enkele niche bepalingen van INstruchemie, export naar ca. 40 landen. Galactose * Enzymatic method * Use whole blood or urine * Incl. Galactose Control * Also for automated procedures * Wavelength 340 nm Article nr.: 2935, Galactose Reagent Set Contents: tests Fabrikant: INstruchemie Pyruvate * Enzymatic method * Use whole blood * Incl. Pyruvate Standard * Deproteinization procedure with 8% Perchloric Acid * Also available Lactate/Pyruvate Control, High Level * Wavelength 340, 334, 365 nm Article nr.: 2897, Pyruvate Reagent Set Contents: tests Article nr.: 2896, Lactate/Pyruvate Control Contents: 10 x 5 ml Article nr.: 2933, Deproteinization Reagent Contents: 6 x 100 ml (Comparable with former Sigma method) Fabrikant: INstruchemie Lactate * Enzymatic method * Use whole blood, plasma or cerebrospinal fluid * Incl. Lactate Standard * Deproteinization procedure with 8% Perchloric Acid * Also available Lactate/Pyruvate Control, High Level * Wavelength 340, 334, 365 nm Article nr.: 2864, Lactate Reagent Set Contents: tests Article nr.: 2896, Lactate/Pyruvate Control Contents: 10 x 5 ml Article nr.: 2933, Deproteinization Reagent Contents: 6 x 100 ml (Comparable with former Sigma method) Fabrikant: INstruchemie Chymotrypsin * Colorimetric method * Use Faeces * Incl. Chymotrypsin Control * Wavelength 405 nm * Also available Faecal Sample Preparation Tubes Article nr.: 2909, Chymotrypsin Reagent Set Contents: tests Article nr.: 2505, Faecel Sample Prep. Tubes Contents: 50 tests Fabrikant: INstruchemie Pagina 3 van 10

4 INstruchemie vertegenwoordigd ca. 30 fabrikanten. The Company Aptec: APTEC Diagnostics manufactures and develops highly stable REAGENTS & KITS for IMMUNOTURBIDIMETRY, including calibrators and controls. Since its foundation in 1992, APTEC stands for a solid reputation, focussing on the needs of the customer. Service to distributors is our mian objective. Several major diagnostic companies are now customer on OEM/Private label basis. Our current portfolio lists more than 40 reagents in convenient packages, all CE-labelled. Application Procedures for about 45 different Instruments are available upon request. Our continuous efforts to meet the highest possible quality, has resulted in ISO 9001: 2000 and ISO 13485:2003 certificates. Bi-reagents and/or Mono-reagents: Kits, Calibrators & Controls α1-antitrypsin β2-microglobulin Ultra Sensitive Haptoglobin α1-acid Glycoprotein C1 Esterase Inhibitor HbA1c Direct α1-microglobulin Complement C3 IgA α2-macroglobulin Complement C4 IgD Albumin Ceruloplasmin IgG Anti-streptolysin (O) CRP IgM Antithrombin III CRP Ultra Sensitive Kappa Light Chain APO A1 Ferritin Ultra Sensitive Lambda Light Chain APO A2 Fibrinogen Microalbumin Ultra Sensitive APO B Fibrinonectin Prealbumin Transferrin Therapeutic Drug Monitoring: Kits, Calibrators & Controls Carbamazepine Gentamicin Theophyllline Digitoxin Phenobarbital Valproic Acid Digoxin Phenytoin Manual procedures & Analysers procedures Advia -series (1200, 1650, 2400) Hitachi -series (704, 717, 902, 911, Space 912, 917) Aeroset Ilab -series (500, 600, 900) Synchron -series (CX, LX) Alcyon Konelab 20i Wako -series (20R, 30R) Architec Mega XL 600 AU -series (400, 560, 2700, 5400) Modular Axon Monarch Cobas Mira Opera Dimension RA -series (1000, 1000-XT) Express 500 Selectra -series (1,2) Pagina 4 van 10

5 STANDAARDISATIE URINE SEDIMENTEN ONDERZOEK: KOVA SYSTEEM SINDS Standaardisatie urine sedimenten onderzoek: Urine controles: KOVA-controls - - Hygiënisch en schoon. Dekglaasjes overbodig. Steeds dezelfde hoeveelheid urine in onderzoek. Eenvoudig en snel. Tot 10 sedimenten in één telkamer. Aanbevolen methode in meer dan 100 landen. CE gemarkeerd. Complete KOVA System: KOVA System Pac 10 with grids: Contains: Determination of 1000 Urine sediments Art. nr.: x 500 KOVA Economy Tubes, x 500 Petters, x 100 Glasstic Slides with grids, levels: * High abnormal. * Abnormal. * Normal. Vloeibaar en gevriesdroogd. Tevens geschikt voor Urine Strips & Readers van alle fabrikanten. KOVA System Pac 10 without grids: Contains: Determination of 500 Urine sediments Art. nr.: x 500 KOVA Economy Tubes, x 500 Petters, x 50 Glasstic Slides without grids, Chamber of Commerce Groningen Pagina 5 van 10

6 KOVA Urinanalysis Controls. KOVA-TROL I, II, III * Kova-Trol is a freeze-dried human urine control for qualitative procedures used in physiochemical and chemical determinations and for microscopic sediment analyses. KOVA-Liqui-TROL I, II * Kova Liqua-Trol with Microscopics is a ready-to-use liquid product as control for qualitative procedures used in physiochemical and chemical determinations and for microscopic sediment analyses. * Directions for use with reagent strips * Standardized urinalysis procedures * Value Assignment for: Reagent Test Strips: Bayer, Roche, etc. ph, Protein, Glucose, Ketones, Bilirubin, Blood (Hb), Nitrite, Uribilinogen, Specific Gravity, Leukocyte Esterase, Microalbumin, Creatinine * Physical characteristics: Appearance, Color, Specific Gravity, Osmolatiy, ph. * Alternative Tests: Glucose/Clinitest, Bilirubin/Icotest, Ketone/Acetest, Protein/Sulfosalicylic Acid (3%) Qualitative, Quantitave. * Microscopic Quality Control Cell Counts: Qualitaive; Red Cells/ hpf, White Cells/hpf Quantitaive; Red Cells/ hpf, White Cells/hpf. * Pregnancy Testing: Beckman Coulter ICON II HCG Quidel Quick Vue hcg Bayer Clinitest hcg All other qualitative procedures Article nr.: Contents; 87329, KOVA-Trol I, High Abnormal 4 x 15 ml 87130, KOVA-Trol II, Low Abnormal 4 x 15 ml 87331, KOVA-Trol III, Normal with hcg 4 x 15 ml Article nr.: Contents; 87122, KOVA Liqua-Trol II, Normal with hcg 2 x 120 ml 87176, KOVA Liqua-Trol I, Abnormal 2 x 120 ml 37036, KOVA Liqua-Trol I, Abnormal 1 x 120 ml KOVA Liqua-Trol II, Normal with hcg 1 x 120 ml Pagina 6 van 10

7 Stabilur Tablets: Stabilize Urine Specimens For Delayed Laboratory Microscopic Examination of Urine Sediment Maintains* Red and White Blood Cells in Original Condition - Prevents the usual rapid lysis of leukocytes to assure accurate confirmation of this key indicator of urinary tract infection.1 - Permits accurate counting and estimation or erythrocytes Maintains* the Morphology of Typical Formed Elements in Urine Sediment Such as Casts, Crystals and Mucous Threads - Morphology and staining characteristics of casts and cells are retained in original condition. - Tablet dissolves completely, and does not contribute any crystals to the sediment.2 * Protects unrefrigerated specimens circa three days. Maintains* Most Urine Dipstick Chemistries Maintains most chemical constituents in urine for retesting by dipstick chemistry by preventing bacterial decomposition. - Does not interfere with enzyme based dipstick chemistry tests, i.e. leukocyte esterase.3 - At recommended levels urine ph is buffered to just under neutral, and specific gravity is raised *Maintains Other Chemistry Assay Components - Does not interfere with certain TLC and RIA methods for assay of physiological marker compounds and drugs and their metabolytes. Whole Blood Erythrocyte Sedimentation Control (ESR): SEDRite Plus SEDRite Plus is a control designed to monitor erythrocyte sedimentation rate (ESR) values obtained from manual and automated ESR methods. This control is composed of stable materials that provide a means of monitoring the performance of manual and automated ESR methods. Use these controls in the same manner as an EDTA anti-coagulated patient specimen. Methods & Instruments: Manual method: Westergreen saline diluted Westergreen sodium citrate diluted Westergreen undiluted Wintrobe Package / kit: Contains 2 levels Several package sizes / vials. Stability: 3 months Automated method / Instruments: Starrsed Roche Diesse/Menarini Clinical Data Terumo Technique Biologique Biocade Becton Dickinson Greiner/Sayag Sarstedt Eurotec Med. Syst. Cofim All. Diag. Other Instruments. Pagina 7 van 10

8 Free Fatty Acids NEFA C * ACS-ACOD-MEHA Colorimetric method * Use Serum * Also available: NEFA Standard Control Serum I & Control Serum II * Wavelength 550 nm Enkele niche bepalingen van buitenlandse fabrikanten. Article nr.: , NEFA C Contents; 6 x 30 ml Article nr.: , NEFA Standard Contents; 4 x 10 ml Article nr.: , Control Serum I Contents; 10 x 5 ml Article nr.: , Control Serum II Contents; 10 x 5 ml HEXAGON OBTI TEST * Immunologische sneltest voor specifieke detectie van humaan occult bloed in faeces * Verpakking: 24 testen, CE-gemarkeerd * Meest betrouwbare methodiek. * Klinische specificiteit: > 99% * Klinische gevoeligheid: > 99% * Detectielimiet: 0,05 mg Hb /gram faeces. * Ingebouwde negatieve controle. * Geen storende stoffen bekend. * Patiënt hoeft geen dieet te volgen. * Werkt zeer hygiënisch en geurloos. * Resultaat binnen 5 minuten. * Eventuele follow-up methode na een positieve à specifieke Guaiac methode uitslag. Fabrikant: Wako GmbH Fabrikant: Human GmbH Phospholipids * CHO-POD method * Use Serum or Plasma * Incl. Standard * Wavelength 505 nm Article nr.: , Phospholipids Contents; 5 x 10 ml Fabrikant: Spinreact Total Bile Acids * Enzymatic cycling, kinetic method * Use Serum or Plasma * Incl. Bile Acid Standard * Wavelength 405 nm Article nr.: DZA042A, Total Bile Acids Contents; 2x60/2x20ml Fabrikant: Diazyme Pagina 8 van 10

9 Sommige leveranciers * Laboratorium Informatie Management Systeem Modules voor: * Ziekenhuis-, huisartsen-, microbiologische-, privé-, IVF-, gerechtelijke-, bloedbank-, veterinaire-, geneesmiddelenlaboratoria, etc. * More than antibodies and immunological reagents * Human, rodent, veterinary, cell biology, cytokine, neurology, microbiology * In-Vitro Diagnostics: Kits & Determinations * Clinical Biochemistry, Immunochemistry * Also niche determinations: Phospholipids, Cholinesterase, Apo A1, B, C-II, C-III, E, Antithrombine III * Rapid Tests (For Professional Use Only) * Fertility * Drugs of Abuse * Infectious Disease * Tumor Markers * Cardiac Markers * In-Vitro Diagnostics: Kits & Determinations * Clinical Biochemistry, Immunochemistry * Hemostasis, Hematology, Elisa * Systems and Instruments * Automated analyzers, Hb Meter, Readers, etc. * Elisa kits; ready-to-use * Measurements: * ELISpot, T-cell & cytokine levels Meer dan 30 fabrikanten vertegenwoordigd INstruchemie in Nederland en tevens een aantal in diverse Europese landen, zie Pagina 9 van 10

10 RETOUR: FAX FORMULIER : Aan Attentie INstruchemie B.V. Sales & Marketing Fons Nieland, Arie Jan de Graaf Tel nr Fax nr Datum februari 2009 Referentie FEN Ik wens: Persoonlijk contact. Over: Meer informatie. Over: Actuele prijzen. Catalogus. Van: Producten / fabrikanten programma in een luxe verzamelmap. (Meer dan 1500 bepalingen, reagens, standaarden, controles). Verzenden naar: Naam: Voorletters Titel: M / V Functie: Instituut: Afdeling: Adres: PC/Plaats: Telefoon : Fax : Pagina 10 van 10