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Cover Page The handle http://hdl.handle.net/1887/35956 holds various files of this Leiden University dissertation. Author: Lagraauw, Hendrik Maxime Title: Stress-induced modulation of the innate immune system in cardiovascular disease Issue Date: 2015-10-22

175 Curriculum Vitae Max Lagraauw werd geboren op 19 december 1987 te Delft. In mei 2006 behaalde hij zijn atheneum diploma aan het Vlietland College in Leiden. In datzelfde jaar begon hij met de studie Life Science & Technology, een combinatie studie van de Universiteit Leiden en de Technische Universiteit Delft. De bachelor fase werd in 2009 afgerond met een wetenschapsstage bij de afdeling dermatologie van het LUMC. Tijdens de master fase werd de focus verder gelegd op het doen van wetenschappelijk onderzoek met twee 7-maandse stages bij de afdeling Medische Farmacologie van het Leiden Academic Centre for Drug research (LACDR) en Inflammation Research Center van de Universiteit Gent. In juli 2011 behaalde hij het doctoraal examen aan de Universiteit Leiden met een 8,3 gemiddeld. Van juli 2011 tot juni 2015 heeft hij zijn promotieonderzoek, dat beschreven staat in dit proefschrift, verricht op de afdeling Biofarmacie van het LACDR onder leiding van dr. Ilze Bot en prof. dr. Johan Kuiper. Dit onderzoek maakte deel uit van het door de Nederlandse Hartstichting gefinancierde project Stress and Acute Cardiovascular Syndromes: A Key Role for Mast Cells? (2010B244). Tijdens zijn periode als promovendus ontving hij in maart 2015 een travel grant van de European Atherosclerosis Society om naar het EAS congres in Glasgow te gaan. Daarnaast ontving hij in april 2015 een Young Investigator Award voor zijn posterpresentatie op de Scandinavian Society for Atherosclerosis Research conferentie in Humlebaek, Denemarken. Om zijn wetenschappelijke kennis te verbreden heeft hij van juli tot en met september 2015 deelgenomen aan de Treeway Summer Challenge 2015, een project opgezet door het biotechnologie bedrijf Treeway. Gedurende dit project, heeft hij samen met 8 andere PhD en Master studenten literatuur en Big Data analyses uitgevoerd, om zo tot nieuwe inzichten te komen voor de behandeling van de spier- en zenuwziekte amyotrophische laterale sclerosis (ALS).

176

Publications 177 Publications Full papers Lagraauw HM, Wezel A, van der Velden D, Kuiper J, Bot, I. Stress-induced mast cell activation contributes to atherosclerotic plaque destabilization. Manuscript in preparation. Van der Velden D, Lagraauw HM, Wezel A, Launay P, Kuiper J, Huizinga TWJ, Toes REM, Bot I, Stoop JN. Mast cell depletion in the prodromal phase of collagen induced arthritis reduces clinical outcome by lowering the inflammatory cytokine profile. Submitted. Wezel A, Welten SM, Razawy W, Lagraauw HM, de Vries MR, Kandimalla ER, Kuiper J, Quax PHA, Nossent AY, Bot I. 14q32 MicroRNA Inhibition Reduces Atherosclerotic Lesion Formation and Increases Plaque Stability. Accepted by Annals of Surgery. Lagraauw HM, Kuiper, J, Bot I. Acute and chronic psychological stress as risk factors for cardiovascular disease: Insights gained from epidemiological, clinical and experimental studies. Brain, Behav. Immun. 2015, in press. Lagraauw HM*, Wezel A*, van der Velden D, de Jager SC, Quax PHA, Kuiper J, Bot I. Mast cells mediate neutrophil recruitment during atherosclerotic plaque progression. Atherosclerosis. 2015;241(2):289-296. (*These two authors contributed equally) Frodermann V, van Puijvelde GH, Wierts L, Lagraauw HM, Foks AC, van Santbrink PJ, Bot I, Kuiper J, de Jager SC. Oxidized Low-Density Lipoprotein-Induced Apoptotic Dendritic Cells as a Novel Therapy for Atherosclerosis. J Immunol. 2015;194(5):2208-2218.

178 Publications Wezel A, van der Velden D, Maassen JM, Lagraauw HM, de Vries MR, Karper JC, Kuiper J, Bot I, Quax PHA. RP105 deficiency attenuates early atherosclerosis via decreased monocyte influx in a CCR2 dependent manner. Atherosclerosis. 2015;238(1):132-139. Wezel A, de Vries MR, Lagraauw HM, Foks AC, Kuiper J, Quax PHA, Bot I. Complement factor C5a induces atherosclerotic plaque disruptions. J Cell Mol Med. 2014;18(10):2020-30. Lagraauw HM, Westra MM, Bot M, Wezel A, van Santbrink PJ, Pasterkamp G, Biessen EA, Kuiper J, Bot I. Vascular neuropeptide Y contributes to atherosclerotic plaque progression and perivascular mast cell activation. Atherosclerosis. 2014;235(1): 196-203. Bot M, de Jager SCA, MacAleese L, Lagraauw HM, van Berkel TJC, Quax PHA, Kuiper J, Heeren RMA, Biessen EAL, Bot I, Lysophosphatidic acid triggers mast celldriven atherosclerotic plaque destabilization by increasing vascular inflammation. Journal of Lipid Research. 2013: 54(5):1265-1274. Published abstracts Lagraauw HM, Wezel A, van der Velden D, Kuiper J, Bot I. Stress-induced mast cell activation contributes to atherosclerotic plaque destabilization. Atherosclerosis. 2015;241(1),e13-e14. Frodermann V, van Puijvelde GHM, Wierts L, Lagraauw HM, van Santbrink PJ, Bot I, Kuiper J, de Jager SCA. OxLDL-induced apoptotic dendritic cells as a novel therapy for atherosclerosis. Atherosclerosis, 2015;241(1):e7. Lagraauw HM, Westra MM, Bot M, Wezel A, van Santbrink PJ, Pasterkamp G, Biessen EA, Kuiper J, Bot I. Vascular neuropeptide Y contributes to atherosclerotic plaque progression and perivascular mast cell activation. Arteriosclerosis, Thrombosis, and Vascular Biology. 2014;34:A459. Wezel A, Lagraauw HM, van der Velden D, de Jager SC, Quax PHA, Kuiper J, Bot I. Mast cell-mediated neutrophil influx enhances plaque progression. Arteriosclerosis, Thrombosis, and Vascular Biology. 2014;34:A476.

Publications 179 Wezel A, Welten S, Lagraauw HM, de Vries MR, Kandimalla E, Kuiper J, Quax PHA, Nossent AY, Bot I. 14q32 MicroRNA inhibition reduces atherosclerotic lesion formation, increases plaque stability and lowers cholesterol levels. Arteriosclerosis, Thrombosis, and Vascular Biology. 2014;34:A676. Frodermann V, van Puijvelde GHM, Wierts L, Lagraauw HM, van Santbrink PJ, Bot I, Kuiper J, de Jager SCA. OxLDL-induced apoptotic dendritic cells as a novel therapy for atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology.2014;34:A372. Wezel A, Welten S, Lagraauw HM, de Vries MR, Kandimalla E, Kuiper J, Quax PHA, Bot I, Nossent AY. 14q32 MicroRNA inhibition reduces atherosclerotic lesion formation, increases plaque stability and lowers cholesterol levels. Atherosclerosis. 2014;235(2):e41. Bot I, Wezel A, Lagraauw HM, van der Velden D, de Jager S, Quax PHA, Kuiper J. Mast cell mediated neutrophil influx enhances plaque progression. Cardiovascular research. 2014;103 Suppl. 1: S5. Wezel A, Welten S, Razawy W, Lagraauw HM, de Vries M, Kandimalla E, Kuiper J, Quax PHA, Bot I, Nossent Y. 14q32 MicroRNA inhibition reduces atherosclerotic lesion formation, increases plaque stability and lowers cholesterol levels. Circulation. 2013;128:A14484.