Cover Page. The handle holds various files of this Leiden University dissertation

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1 Cover Page The handle holds various files of this Leiden University dissertation Author: Broek, Colette van den Title: Optimisation of colorectal cancer treatment Issue Date:

2 Optimisation of colorectal cancer treatment Colette van den Broek

3 Drukwerk Optima Grafische Communicatie, Rotterdam 2013 Colette van den Broek Leiden The Netherlands Alle rechten voorbehouden. Niets uit deze opgave mag worden verveelvoudigd, opgeslagen in een geautoriseerd gegevensbestand of openbaar gemaakt, in enige vorm of op enige wijze, hetzij elektronisch, mechanisch, door fotokopieën, opnamen of op enige andere wijze, zonder voorafgaande schriftelijke toestemming van de auteur. All rights reserved. No part of this thesis may be reproduced or transmitted without the prior permission of the author. ISBN

4 Optimisation of colorectal cancer treatment Proefschrift ter verkrijging van de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.mr. C.J.J.M. Stolker, volgens besluit van het College voor Promoties te verdedigen op donderdag 27 februari 2013 klokke uur door Colette Bernadine Maria-Theresia van den Broek geboren te s Hertogenbosch in 1984

5 Promotiecommissie Promotor Prof. Dr. C.J.H. van de Velde Co-promotores Dr. E. Bastiaannet Dr. G.J. Liefers Beoordelingscommissie Dr. A.J.M. de Craen Prof. Dr. A.J. Gelderblom Prof. Dr. C.A.M. Marijnen Prof. Dr. H.J.T. Rutten Academisch Ziekenhuis Maastricht Catharina Ziekenhuis Eindhoven Overige commissieleden Dr. J.E.A. Portielje Prof. Dr. M. Verheij Haga Ziekenhuis Den Haag Antoni van Leeuwenhoek Ziekenhuis Amsterdam Vrije Universiteit Amsterdam

6 Contents Introduction 1 General introduction and outline of this thesis 9 Part I Colorectal cancer; treatment and survival 2 Time trends in chemotherapy (administration and costs) and relative survival in stage III colon cancer patients - a large population-based study from 1990 to 2008 Acta Oncologica 3 Adjuvant chemotherapy use in stage III colon cancer patients Submitted for publication 4 The survival gap between middle-aged and elderly colon cancer patients. Time trends in treatment and survival European Journal of Surgical Oncology 5 Importance of the first postoperative year in the prognosis of elderly colorectal cancer patients Annals of Surgical Oncology 6 Impact of the interval between short course radiotherapy and surgery on outcomes of rectal cancer patients European Journal of Cancer Part II International comparisons in colorectal cancer treatment and survival 7 The EURECCA project: Data items scored by European colorectal cancer audit registries European Journal of Surgical Oncology 8 Differences in preoperative treatment administration of rectal cancer patients between Norway, Sweden, Denmark, Belgium and the Netherlands Submitted for publication 9 A comparison of high dose rate endorectal brachytherapy, short course radiotherapy and chemoradiation on the outcome of rectal cancer patients Submitted for publication Discussion 10. General discussion and future perspectives Summary Summary in Dutch (Nederlandse samenvatting) Appendices List of contributing authors List of publications Acknowledgements (Dankwoord) Curriculum vitae

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