Risk prediction and risk reduction in patients with manifest arterial disease Nadine Goessens
Risk prediction and risk reduction in patients with manifest arterial disease Utrecht, Universiteit Utrecht, Faculteit Geneeskunde Thesis University Utrecht - with a summary in Dutch Proefschrift Universiteit Utrecht - met een samenvatting in het Nederlands ISBN-10 90-393-4294-6 ISBN-13 978-90-393-4294-7 Author B.M.B. Goessens Cover P. van Hugten Lay-out Haaring Automatisering, Scherpenzeel Print Gildeprint Drukkerijen B.V., Enschede, the Netherlands
Risk prediction and risk reduction in patients with manifest arterial disease Risicovoorspelling en risicoverlaging bij patiënten met manifest vaatlijden (met een samenvatting in het Nederlands) Proefschrift ter verkrijging van de graad van doctor aan de Universiteit Utrecht op gezag van de rector magnificus, prof. dr. W.H. Gispen, ingevolge het besluit van het college voor promoties in het openbaar te verdedigen op woensdag 20 december 2006 des ochtends te 10.30 uur door Bertine Mathieu Barbara Goessens geboren op 30 december 1976 te Geleen
Promotores : Prof. dr. Y. van der Graaf Julius Center for Health Sciences and Primary Care Co-promotor : Dr. F.L.J. Visseren Department of Internal Medicine, Section of Vascular Medicine Two studies described in this thesis were supported by ZonMw, the Netherlands Organization for Health Research and Development, (grant nr. 32250009) and (grant nr. 61000009). Financial support by ZonMw and the Netherlands Heart Foundation for the publication of this thesis is gratefully acknowledged. Financial support was also provided by the Julius Center for Health Sciences and Primary Care, Merck Sharp & Dohme, Boehringer Ingelheim, Pfizer bv, and Servier Nederland Farma B.V.
Manuscripts based on the studies presented in this thesis Chapter 2 Goessens BMB, Visseren FLJ, van der Graaf Y. Life expectancy in the elderly with and without vascular disease: review of the current literature. In Vascular procedures in the elderly patient ISBN-13: 978-0-9553015-0-6. Chapter 3 Goessens BMB, Visseren FLJ, Algra A, Banga JD, van der Graaf Y. Screening for asymptomatic cardiovascular disease with non-invasive imaging in patients at high risk and low risk according to the European Guidelines on Cardiovascular Disease Prevention. The SMART study. J Vasc Surg. 2006;43:525-32. Chapter 4 Goessens BMB, Visseren FLJ, Kappelle LJ, Algra A, van der Graaf Y. Asymptomatic carotid artery stenosis and the risk of new vascular events in patients with manifest arterial disease. The SMART study. In revision Stroke. Chapter 5 Goessens BMB, Visseren FLJ, Edlinger M, Zuithoff NPA, Algra A, van der Graaf Y. Performance of the Framingham, PROCAM, and SCORE algorithms in predicting recurrent vascular events in patients with clinical manifestations of arterial disease and the development of a new risk model. The SMART Study. Submitted. Chapter 6 Goessens BMB, van der Graaf Y, Olijhoek JK, Visseren FLJ. The course of vascular risk factors and the occurrence of vascular events in patients with symptomatic peripheral arterial disease. Accepted for publication in J Vasc Surg. Chapter 7 Goessens BMB, Visseren FLJ, Olijhoek JK, Eikelboom BC, van der Graaf Y. Multidisciplinary vascular screening program modestly improves the medical treatment of vascular risk factors. Cardiovasc Drugs Ther. 2005;19 (6):429-35. Chapter 8 Goessens BMB, Visseren FLJ, Sol BGM, de Man - van Ginkel JM, van der Graaf Y. A randomized controlled trial for risk factor reduction in patients with symptomatic vascular disease: the multidisciplinary Vascular prevention by NUrses Study. Accepted for publication in Eur J Cardiovasc Prev Rehabil. Chapter 9 Goessens BMB, Visseren FLJ, de Nooijer J, van den Borne HW, Algra A, Wierdsma J, van der Graaf Y. Self-management of vascular Patients Activated by the Internet and Nurses (SPAIN) study: Rationale and Design. Based on a short paper published as proceeding in Lecture Notes in Computer Science 2006; 3962:162-166.