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1 OTHER PUBLICATIONS 1. Rodondi N, den Elzen WP, Bauer DC, Cappola AR, Razvi S, Walsh JP, Åsvold BO, Iervasi G, Imaizumi M, Collet TH, Bremner A, Maisonneuve P, Sgarbi JA, Khaw KT, Vanderpump MP, Newman AB, Cornuz J, Franklyn JA, Westendorp RG, Vittinghoff E, Gussekloo J, for the Thyroid Studies Collaboration. Subclinical hypothyroidism and the risk of coronary disease and mortality. JAMA accepted August de Ruijter W, Westendorp RG, Assendelft WJ, den Elzen WP, de Craen AJ, le Cessie S, Gussekloo J. Use of Framingham risk score and new biomarkers to predict cardiovascular mortality in older people: population based observational cohort study. BMJ. 2009;338a den Elzen WP, Westendorp RG, Frolich M, de Ruijter W, Assendelft WJ, Gussekloo J. Role of Vitamin B12 in Anemia in Old Age In reply. Arch Intern Med. 2009;169(12): Sliedrecht A, den Elzen WP, Verheij TJ, Westendorp RG, Gussekloo J. Incidence and predictive factors of lower respiratory tract infections among the very elderly in the general population. The Leiden 85-plus Study. Thorax. 2008;63(9): den Elzen WP, Groeneveld Y, de Ruijter W, Souverijn JH, le Cessie S, Assendelft WJ, Gussekloo J. Long-term use of proton pump inhibitors and vitamin B12 status in elderly individuals. Aliment Pharmacol Ther. 2008;27(6): den Elzen WP, van Manen JG, Boeschoten EW, Krediet RT, Dekker FW. The effect of single and repeatedly high concentrations of C-reactive protein on cardiovascular and non-cardiovascular mortality in patients starting with dialysis. Nephrol Dial Transplant. 2006;21(6):

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3 NAWOORD Velen hebben bijgedragen aan de totstandkoming van dit proefschrift. In eerste instantie gaat mijn dank uit naar de deelnemers van de Leiden 85-plus Studie en de Newcastle 85-plus Study. Daarnaast dank ik allen die betrokken waren bij de opzet en uitvoering van beide studies. De afgelopen vijf jaar heb ik met veel plezier aan dit promotieonderzoek gewerkt. Dit kwam niet alleen door de uitdagende inhoud van het project, maar ook door de inspirerende werkomgeving en leuke collega s op de afdeling Public Health en Eerstelijnsgeneeskunde. In het bijzonder wil ik Wouter de Ruijter bedanken. Wouter, ik prijs me gelukkig jou als kamergenoot en paranimf te hebben. Ik kan altijd bij je terecht; niet alleen voor moeilijke wetenschappelijke en klinische vraagstukken, maar ook voor dingen die niet werk-gerelateerd zijn. ISCOPE-dames Jeanet Blom, Anne van Houwelingen en Margot Heijmans: dank voor de fijne samenwerking binnen ISCOPE. Jullie zijn een sterk, hardwerkend, motiverend en gezellig team. We gaan van ISCOPE een mooi en succesvol project maken. Ton de Craen en Friedo Dekker, tijdens mijn stages heb ik veel van jullie geleerd. Mede door jullie ben ik na mijn studie Biomedische Wetenschappen doorgegaan in het klinisch epidemiologisch onderzoek. Professor Tom Kirkwood, Dr Joanna Collerton, Dr Carmen Martin-Ruiz: thank you for showing me all the ins and outs of the Newcastle 85-plus Study and for inviting me into your homes. In my six months in Newcastle I did not only learn about the biology of aging, but also about how to start a new life in your beautiful country, so close to home but so very different from home. Room mates Karen Davies, Sally Barker, Joan Hughes, June Edwards, Judith Hunt, and Lucy Farfort, you are absolutely fabulous. I really miss our chocolate breaks. Er zijn nog een aantal anderen die ik op deze plaats wil bedanken. On Ying Chan, Marjolein Overmeer, Ganna van Bijleveld, Marlies Laros en Paula van den Berg; de uren die ik niet in het LUMC achter de computer zit, breng ik graag met jullie door. Ying, je bent de ultieme paranimf. Tijdens onze studie heb je me al door alle laboratoriumpractica heen geloodst. Ik kijk nu al uit naar de verdediging van jouw proefschrift. Mijn badmintonmaatjes van Badminton Klub Noordwijkerhout: jullie zijn die eindeloze busrit naar Noordwijkerhout meer dan waard. Met jullie op de baan en aan de bar is de perfecte combi van inspanning en ontspanning. Ik zal proberen mijn zakenreizen voortaan om de trainingen en competitie heen te plannen. Pap, mam en Tamara: dank voor jullie onvoorwaardelijke steun en vertrouwen. Van jullie heb ik geleerd dat niets onmogelijk is. Dit proefschrift is daar een bewijs van, en is hopelijk pas het begin. Ta, laten we snel op reis gaan om te vieren dat dit klaar is. 155

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5 CURRICULUM VITAE Wendy den Elzen was born on 29 January 1983 in Noordwijkerhout, the Netherlands. She passed her Gymnasium exam at Teylingen College locatie Leeuwenhorst in Noordwijkerhout in She studied Biomedical Sciences at the Leiden University Medical Center from 2001 through 2006 (cum laude). In 2006, she started as a PhD student on the research project described in this thesis at the department of Public Health and Primary Care of the Leiden University Medical Center. In 2008, she worked at the Institute for Ageing and Health (Newcastle University, Newcastle upon Tyne, UK) for six months. After the completion of this thesis, she will continue to work as a postdoc researcher at the department of Public Health and Primary Care of the Leiden University Medical Center. She will continue her research into anemia in old age and will be involved in ISCOPE (Integrated Systematic Care for Older People, NTR1946). ISCOPE is a large multicenter trial that assesses the value and cost-benefit of a monitoring system for deterioration in somatic, functional, mental or social health of individuals aged 75 years and over in general practice followed by the execution of a care plan for those people with a combination of problems. 157

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