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1 Cover Page The handle holds various files of this Leiden University dissertation. Author: Beek, Martha Trijntje van der Title: Herpesvirus infections in immunocompromised patients : treatment, treatment failure and antiviral resistance Issue Date:

2 List of Publications

3 List of Publications M.T. van der Beek, L.G. Visser, M.P. de Maat Yellow fever vaccination as a model to study the response to stimulation of the inflammation system. Vascul Pharmacol. 2002; 39: M.T. van der Beek, W. Taal, R.F. Veldkamp, C.J. Vecht A woman with multiple sclerosis and pink saliva. Lancet Neurol. 2003; 2: M. Verschuur, M.T. van der Beek, H.S. Tak, L.G. Visser, M.P. de Maat Interindividual variation in the response by fibrinogen, C-reactive protein and interleukin-6 to yellow fever vaccination. Blood Coagul Fibrinolysis. 2004; 15: M.T. van der Beek, A.C.M. Kroes Wat zijn de conclusies van de moderne EBV-antistoffen-testen: EBV IgG/lgM en EBNA IgG? Vademecum permanente Nascholing Huisartsen. 2007, september. M.T. van der Beek, A.T. Bernards, R. Lapid-Gortzak Mycobacterium chelonae keratitis in a patient with Sjögren s syndrome. Eur J Ophthalmol. 2008; 18: M.T. van der Beek, W. van Pelt, L. Heres, K. Veldman, J.A. Wagenaar, W. Jacobs-Reitsma, D.J. Mevius, E.J. Kuijper Methoden voor isolatie, identificatie en gevoeligheidsbepaling van Campylobacter spp.. Nederlands Tijdschrift voor Medische Microbiologie. 2009, 17;6-12. M.T. van der Beek, E.C.J. Claas, D.J. Mevius, W. van Pelt, J.A. Wagenaar, E.J. Kuijper Inaccuracy of routine susceptibility tests for detection of erythromycin resistance of Campylobacter jejuni and Campylobacter coli. Clin Microbiol Infect. 2010; 16:

4 List of Publications M.T. van der Beek, S.P. Berger, A.C.T.M. Vossen, C.S. van der Blij-de Brouwer, R.R. Press, J.W. de Fijter, E.C.J. Claas, A.C.M. Kroes Preemptive versus sequential prophylactic-preemptive treatment regimens for cytomegalo virus in renal transplantation: comparison of treatment failure and antiviral resistance. Transplantation. 2010; 89: B.J. de Rooij, M.T. van der Beek, B. van Hoek, A.C.T.M. Vossen, R.W. Ten Hove, A. Roos, A.F. Schaapherder, R.J. Porte, J.J. van der Reijden, M.J. Coenraad, D.W. Hommes, H.W. Verspaget Mannose-binding lectin and Ficolin-2 gene polymorphisms predispose to cytomegalovirus (re)infection after orthotopic liver transplantation. J Hepatol. 2011; 55: C.C. Posthuma*, M.T. van der Beek*, C.S. van der Blij-de Brouwer, P.L. van der Heiden, W.A.F. Marijt, W.J. Spaan, E.C.J. Claas, C. Nederstigt, A.C.T.M. Vossen, E.J. Snijder, A.C.M. Kroes Mass spectrometry-based comparative sequencing to detect ganciclovir resistance in the UL97 gene of human cytomegalovirus. J Clin Virol. 2011; 51: *these authors contributed equally to this work I. Jedema, M. van de Meent, J. Pots, M.G. Kester, M.T. van der Beek, J.H. Falkenburg Successful generation of primary virus-specific and anti-tumor T-cell responses from the naive donor T-cell repertoire is determined by the balance between antigen-specific precursor T cells and regulatory T cells. Haematologica. 2011; 96: M.T. van der Beek, W.A.F. Marijt, A.C.T.M. Vossen, C.S. van der Blij-de Brouwer, R. Wolterbeek, C.J.M. Halkes, E.C.J. Claas, A.C.M. Kroes Failure of preemptive treatment of cytomegalovirus infections and antiviral resistance in stem cell transplant recipients. Antiviral Therapy. 2012; 17:

5 List of Publications M.T. van der Beek*, A.M.G.A. Laheij*, J.E. Raber-Durlacher, P.A. von dem Borne, R. Wolterbeek, C.S. van der Blij-de Brouwer, C. van Loveren, E.C.J. Claas, A.C.M. Kroes, J.J. de Soet, A.C.T.M. Vossen Viral loads and antiviral resistance of Herpesviruses and oral ulcerations in hematopoietic stem cell transplant recipients. Bone Marrow Transplantation., advance online publication 13 February 2012; doi: /bmt *these authors contributed equally to this work M.T. van der Beek, E.C.J. Claas, C.S. van der Blij-de Brouwer, F. Morfin, L.G. Rusman, A.C.M. Kroes, A.C.T.M. Vossen Rapid susceptibility testing for Herpes Simplex Virus type 1 using real-time pcr. J Clin Virol., advance online publication 28 September 2012; doi: /j.jcv M.T. van der Beek, C.L. Vermont, R.G.M. Bredius, P.A. von dem Borne, C.S. van der Blij-de Brouwer, A.C.M. Kroes, E.C.J. Claas, A.C.T.M.Vossen Persistence and antiviral resistance of VZV in hematological patients Clin Infect Dis., accepted. 182

6 Curriculum Vitae

7 Curriculum Vitae 184

8 Curriculum Vitae Martha van der Beek werd geboren in 1977 te Zoetermeer. Zij doorliep de middelbare school van 1989 tot en met 1995 aan het Christelijk Gymnasium Sorghvliet te Den Haag. In 1995 begon zij aan de studie Biomedische Wetenschappen aan de Universiteit Leiden en in 1998 begon zij daarnaast aan de studie Geneeskunde aan deze universiteit. Wetenschappelijke stages werden achtereenvolgens in het Leids Universitair Medisch Centrum doorgebracht bij de afdelingen Endocrinologie bij dr. M.M. Deckers en prof. dr. C.W. Löwik en bij de afdeling Experimentele Hematologie, bij dr. M. Vogt en prof. dr. J.H.F. Falkenburg. De afstudeerstage naar determinanten van de ontstekingsrespons op gele koorts vaccinatie werd verricht bij de Divisie Vaat- en Bindweefselonderzoek van TNO Preventie en Gezondheid in samenwerking met de afdeling Infectieziekten van het Leids Universitair Medisch Centrum onder begeleiding van dr. M.P.M. de Maat, dr. L.G. Visser, prof. dr. A. van der Laarse. In 2001 behaalde zij voor beide studies cum laude het doctoraal examen en in 2003 behaalde zij het artsexamen cum laude. In 2003 en 2004 werkte zij als assistent-geneeskundige niet in opleiding bij de afdeling Interne Geneeskunde van het Diaconessenhuis te Leiden. In 2004 werd begonnen aan de opleiding tot arts-microbioloog bij prof. dr. A.C.M. Kroes bij de afdeling Medische Microbiologie van het Leids Universitair Medisch Centrum. Alhier werd in 2007 een aanvang gemaakt met het promotieonderzoek onder begeleiding van dr. A.C.T.M. Vossen en prof. dr. A.C.M. Kroes. In 2009 werd zij geregistreerd als arts-microbioloog en sindsdien is zij werkzaam als zodanig in het Leids Universitair Medisch Centrum. 185

9 Curriculum Vitae 186

10 Nawoord

11 Nawoord Vanwege hun niet aflatende inzet, enthousiasme en altijd goede ideeën op het gebied van onderzoek en zeker ook daarbuiten dank ik Caroline en Ann. Een prettiger samenwerking bestaat niet. We moeten snel weer een project verzinnen. Louis, jij hebt mijn wens wetenschappelijk onderzoek te doen vanaf de dag dat ik bij de Medische Microbiologie begon ondersteund en mij het vertouwen en de vrijheid gegeven dit te doen. Dank voor je brede en kritische blik. Nathalie, Jutte en Sunita, het was me een groot genoegen met jullie smerige automaatkoffie, daglichtarme kantoorruimtes, een ijskoude doka, diverse kalenders, meerdere kamerplanten, uiteenlopende hotelkamers en (promotie) vreugde en smart te delen. Laten we dit tot ver na onze promotie voortzetten! Dank aan Eric C. voor permissie voor nested pcr (en de talloze zinvolle suggesties). Hoef ik nu nooit meer een GenBank submission te doen? Carolien, Lisette, Tom en Jeffrey dank ik voor de enthousiaste inzet tijdens hun stages. Dank aan Clara en Eric S. voor de prettige samenwerking en het mooie AVITA logo, waarmee menig koffiebeker bij de MM nu versierd is. Alexa en Judith, dank dat jullie mij hebben ingewijd in de tandheelkunde, want dat was niet alleen heel plezierig, maar ook erg leerzaam. Dank ook zeker aan de collega s en patiënten van de afdelingen Maag- darm en leverziekten, Hematologie, Kindergeneeskunde en Nierziekten zonder wie dit onderzoek niet mogelijk was geweest. Vanwege het ruimhartig tolereren van mijn virologisch onderzoek dank ik Sandra, Karin Ellen, Jairo en Ed. Hopelijk zal het deellaboverschrijdend werk ons ook in de toekomst niet alleen veel nuttigs, maar ook veel aangenaams brengen. Alle collega s dank ik voor de collegialiteit, zoals het bijbrengen van de beginselen van de viruskweek (CvZ), het leren van Glims trucs (rood en blond), het delen van kennis over tupperware en goede TV-series (SB), het leren waarderen van uiteenlopende smaken (KOMMAdames), het beantwoorden van domme vragen (MJWAMvB e.v.a.), het leveren van 1 april inspiratie (MF, EvO), het vergroten van mijn zinloze feitenkennis (MPB), het beheren van de thee-en soepvoorraad (FS), demonstreren dat een Zwitsers treinkaartje ter plekke veel goedkoper is (KEV) en het bekijken van het noorderlicht zonder jas (wie had eigenlijk die sleutel binnen laten liggen?). 188

12 Nawoord Voor hun trouwe vriendschap, ondanks of juist dankzij, het feit dat we zowel geografisch als beroepsmatig diverse richtingen op zijn gegaan, dank ik Neeltje, Yvette, Nicole en Bianca. Laten we nog vaak een boswandeling maken, ook al zijn we nu te oud voor de jeugdherberg. Vanwege de inspiratie voor en steun bij het doen van een tweede studie en alles daarna dank ik Kirsten, Majida en Nienke. Zo lang er een orthopedische schoen voor is, komt het altijd goed. Jan D. verdient veel dank, omdat hij het werkend en gezinslevend bestaan zo eenvoudig maakt. Vanwege het hardlopen dat alles in balans houdt, dank ik Annerieke en Marielle; laten we daar nooit mee ophouden. Omdat mijn werk in het algemeen en wetenschappelijk onderzoek in het bijzonder hen in het geheel niet interesseren, dank ik Naomi en Joaquim. Omdat ze mij hebben leren kiezen en sindsdien elke gemaakte keuze van harte ondersteunen, dank ik mijn ouders. Voor zijn altijd geïnteresseerde luisterende oor en omdat hij vaak zo goed weet wat ik wil, dank ik Leroy. 189

13

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