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3 List of publications PAPERS SGC van Elderen, JJM Westenberg, A Brandts, RW van der Meer, JA Romijn, JWA Smit, A de Roos. Increased aortic stiffness measured by magnetic resonance imaging in type 1 diabetes mellitus patients and the relationship with renal function. American Journal of Roentgenology, accepted 2010 SGC van Elderen, MJ Versluis, JJM Westenberg, H Agarwal, NB Smith, M Stuber, A de Roos, AG Webb. Right coronary magnetic resonance angiography at 7 Tesla: a direct quantitative comparison with 3 Tesla in young healthy volunteers. Radiology, 2010, Oct; 257(1): SGC van Elderen, A de Roos, AJM de Craen, RGJ Westendorp, GJ Blauw, JW Jukema, ELEM Bollen, HAM Middelkoop, MA van Buchem, J van der Grond. Progression of brain atrophy and cognitive decline in diabetes mellitus, a 3 year follow-up. Neurology, 2010, Sept; 75(11): SGC van Elderen, A Brandts, JJM Westenberg, MA van Buchem, J van der Grond, JT Tamsma, JA Romijn, LJM Kroft, JWA Smit, A de Roos. Aortic stiffness is associated with cardiac function and cerebral small vessel disease in patients with type 1 diabetes mellitus: assessment by magnetic resonance imaging. European Radiology, 2010 May; 20(5): SGC van Elderen, MJ Versluis, AG Webb, JJM Westenberg, J Doornbos, NB Smith, A de Roos, M Stuber. Initial results on in vivo human coronary magnetic resonance angiography at 7 Tesla. Magnetic Resonance in Medicine, 2009 Dec; 62(6): A Brandts, SGC van Elderen, JJM Westenberg, J van der Grond, MA van Buchem, MV Huisman, LJM Kroft, JT Tamsma, A de Roos. Association of aortic arch pulse wave velocity with left ventricular mass and lacunar brain infarcts in hypertensive patients: assessment with MR imaging. Radiology, 2009 Dec; 253(3): AH de Vries, MH Liedenbaum, S Bipat, R Truyen, IWO Serlie, RH Cohen, SGC van Elderen, A Heutinck, O Kesselring, W de Monyé, L te Strake, T Wiersma, J Stoker. Primary uncleansed 2D versus primary electronically cleansed 3D in limited bowel preparation CT-colonography. Is there a difference for novices and experienced readers? European Radiology, 2009 Aug; 19(8): SGC van Elderen, J Doornbos, EHR van Essen, HHPJ Lemkes, JA Maassen, JWA Smit, A de Roos. Phosphorus-31 magnetic resonance spectroscopy of skeletal muscle in maternally inherited diabetes and deafness A3243G mitochondrial mutation carriers. Journal of Magnetic Resonance Imaging, 2009 Jan; 29(1):

4 List of publications HB Grotenhuis, LJM Kroft, SGC van Elderen, JJM Westenberg, J Doornbos, MG Hazekamp, HW Vliegen, J Ottenkamp, A de Roos. Right ventricular hypertrophy and diastolic dysfunction in arterial switch patients without pulmonary artery stenosis. Heart, 2007 Dec; 93(12): ORAL PRESENTATIONS International Society for Magnetic Resonance in Medicine, Montréal, Canada, 2011 Topic: Magnetic resonance angiography, 3 Tesla and beyond; what is there to gain? Society of Cardiovascular Magnetic Resonance Euro CMR, Nice, France, 2011 Topic: Ultra-high field cardiac MR; 7 Tesla and beyond Dutch Radiology days, Veldhoven, the Netherlands, 2010 Cerebral perfusion and aortic stiffness are independent predictors of white matter brain atrophy in type 1 diabetes mellitus patients, assessed with magnetic resonance imaging International Society for Magnetic Resonance in Medicine, Stockholm, Sweden, 2010 Topic: 7 Tesla: Cardiovascular imaging, current status and future prospects Ultrahigh Field MR-Symposium Berlin, Germany, 2010 Topic: Technical developments and role of 7 Tesla in cardiovascular MR Society of Cardiovascular Magnetic Resonance, Phoenix, USA, 2010 Coronary magnetic resonance angiography at 7 Tesla: quantitative comparison with 3 Tesla Dutch Radiology days, Amsterdam, the Netherlands, 2009 Stiffness of the descending aorta is independently related to renal function in type 1 diabetes mellitus patients without evident renal impairment Society of Cardiovascular Magnetic Resonance, Orlando, USA, 2009 In vivo human coronary magnetic resonance angiography at 7 Tesla Netherland Heart Days, Curacao, 2009 MRI assessment of cardiovascular and cerebral damage in diabetes mellitus patients, the role of aortic pulse wave velocity 154

5 List of publications Radiological Society of North America, Chicago, USA, 2008 MRI assessment of cardiovascular and cerebral damage in diabetes mellitus patients, the role of aortic pulse wave velocity Dutch Radiology days, Rotterdam, the Netherlands, 2008 MRI assessment of cardiovascular and cerebral damage in diabetes mellitus patients, the role of aortic pulse wave velocity POSTER PRESENTATIONS International Society for Magnetic Resonance in Medicine, Stockholm, Sweden, 2010 Coronary magnetic resonance angiography at 7 Tesla: quantitative comparison with 3 Tesla American Diabetes Association, New Orleans, Louisiana, USA, 2009 Stiffness of the descending aorta is independently related to renal function in type 1 diabetes mellitus patients without evident renal impairment European Congress of Radiology, Vienna, Austria, 2009 Phosphorus: 31 magnetic resonance spectroscopy of skeletal muscle in maternally inherited diabetes and deafness A3243G mitochondrial mutation carriers Society of Cardiovascular Magnetic Resonance, Orlando, USA, 2009 The role of aortic arch stiffening in cardiac and cerebral damage in type 1 diabetes mellitus patients, assessed by magnetic resonance imaging European Society of Cardiology Congress, Stockholm, Sweden, 2005 Assessment with MRI of right ventricular function and pulmonary circulation in patients with transposition of the great vessels after arterial switch operation during long-term follow-up 155

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7 Dank woord

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9 Dankwoord DANKWOORD Graag wil ik alle collega s bedanken voor de fijne samenwerking tijdens mijn promotieonderzoek. De artsen, secretaresses en verpleegkundige van de diabetes polikliniek wil ik hartelijk danken voor hun inzet omtrent de inclusie. Veel dank aan alle patiënten en vrijwilligers die bereid waren deel te nemen aan het MRI onderzoek. Alle geneeskunde studenten die me hebben geholpen met het scannen en de uitwerking daarvan, dankjulliewel. Graag wil ik mijn kamergenoten en lunch-collega s bedanken voor hun gezelligheid. Heyn, dank voor het zijn van een motiverende collega en vriend. Jos, bedankt voor je bijzondere toewijding. Jeroen, ik heb van je heldere aanpak geleerd. Joost, bedankt voor je hulpvaardigheid en MR fysica uitleg. Gerrit, bedankt voor jouw illustratieve hulp. De mannen van de technische ondersteuning radiologie veel dank voor het redden van mijn studie materiaal. Voor alle lieve familie en vrienden, dank! 159

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11 Curriculum vitae

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13 Curriculum vitae CURRICULUM VITAE Saskia Gerdina Cornelia van Elderen werd geboren op 1 juli 1982 te Eindhoven. Na het behalen van het VWO-diploma aan het scholengemeenschap Durendael te Oisterwijk startte zij in 2000 met de opleiding Geneeskunde aan de Universiteit van Leiden. Gedurende haar doctoraalfase studeerde zij als keuze-vak Spaans aan de Universiteit van Valencia in Spanje. Haar afstudeeronderzoek aan het einde van de doctoraalfase Geneeskunde vond plaats op de afdeling Radiologie onder begeleiding van Dr. H.B. Grotenhuis en Prof. Dr. A. de Roos en beschreef een veranderde dynamiek van de pulmonaal arterie en het effect daarvan op de rechterhartkamerfunctie in arteriële switch operatie patiënten. In 2006 won zij voor haar scriptie de KNMG Dick Held Junior prijs. In de periode van 2005 tot 2007 liep zij coassistentschappen, waaronder een co-assistentschap in het Diaconessenhuis in Paramaribo, Suriname. In 2007 slaagde zij voor haar arts-examen. Ze reisde gedurende 3 maanden door Canada, Noord-Amerika en Mexico. In hetzelfde jaar startte zij haar promotieonderzoek: 'MRI benadering van eind-orgaanschade bij Diabetes en Hypertensie' op de afdelingen Radiologie en Endocrinologie in het Leids Universitair Medisch Centrum onder begeleiding van Prof. Dr. A. de Roos en Prof. Dr. J.W.A. Smit, waarvan de onderzoeksresultaten staan beschreven in dit proefschrift. Zij verrichte gedurende 3 maanden onderzoek naar het effect van met MRI gemeten cerebrale schade op mortaliteit aan het Nationale Instituut voor de Gezondheidszorg (NIH) in Bethesda, Verenigde Staten, op de afdeling Epidemiologie, Veroudering (NIA) onder begeleiding van Prof. M.A. van Buchem en Dr. L.J. Launer. In december 2010 startte zij met de opleiding Radiologie in het Leids Universitair Medisch Centrum. 163

List o f Publications

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