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1 Cover Page The handle holds various files of this Leiden University dissertation Author: Douma, Marit Title: Remifentanil for labour pain : safety and efficacy Issue Date:

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3 Chapter 9 Curriculum Vitae Publications Acknowledgments/Dankwoord

4 Curriculum Vitae 114

5 Marit Douma, born July 21st 1980 in Leeuwarden, earned her VWO degree at the Nieuwediep in Den Helder. She was awarded her masters degree in Medicine from the University of Leiden in She then worked as a physician at the department of Obstetrics and Gynaecology at the Kennemer Gasthuis in Haarlem, followed by a position at the Bronovo hospital in The Hague. In 2008 she started her residency in Obstetrics and Gynaecology at the Leiden University Medical Center (LUMC), Leiden and Haga hospital, The Hague ( ) (prof. dr. J.M.M van Lith, dr. E.J. van Rijssel, dr. B.W.J. Hellebrekers). The research described in this thesis (prof. dr. A. Dahan, prof. dr. J.M.M van Lith) was combined with her residency. In 2015 she joined the Department of Obstetrics and Gynaecology at the Ikazia hospital in Rotterdam as a staff member where she completed her thesis. From January 2017 she will be a staff member at the Haga hospital in The Hague. She currently lives in The Hague with Casper van Pijpen, and their three daughters Flore (2011), Annemijn (2013) and Philine (2016). Chapter 9 115

6 Publications 116

7 Freeman L, Douma MR, Arbous MS, Dahan A, Middeldorp JM. Maternal parameters in women using patient controlled remifentanil and epidural analgesia for pain relief during labour; a subanalysis of the RAVEL trial. Submitted Douma MR, Freeman L, Middeldorp JM, Stijnen T, Dahan AH. Safety of remifentanil during labour: a systematic review and meta-analysis. Submitted BJA Douma MR, Olofsen E, Niesters M, Dahan A. High inspired oxygen concentration increases the speed of onset of remifentanil-induced respiratory depression. Br. J. Anaesth (6): Douma MR, Stienstra R, Middeldorp JM, Arbous S, Dahan A. Differences in maternal temperature and saturation after administration of remifentanil PCA or epidural analgesia during labor. Int J Obst Nov;24(4): Douma MR, Middeldorp JM, Verwey RA, Dahan A, Stienstra R. A randomised comparison of intravenous remifentanil patient-controlled analgesia with epidural ropivacaine/sufentanil during labour. Int J Obstet Anesth Apr;20(2): Liefers WJ, Douma MR, Wolterbeek R, Touw D. Vergelijking van opioïde analgetica tijdens de bevalling: is er een relatie tussen de navelstrengconcentratie van pethidine, fentanyl of remifentanil en de Apgar-score? Pharmaceutisch weekblad. 2011;5:a1127 Wang WY, Douma MR. Toedieningwijze van misoprostol ter inleiding van de baring: vaginaal of oraal? NTOG 2011 Douma MR, Verwey RA, Kam-Endtz CE, van der Linden PD, Stienstra R. Obstetric analgesia: a comparison of patient-controlled meperidine, remifentanil, and fentanyl in labour. Br J Anaesth Feb;104(2): Chapter 9 117

8 Acknowledgments/ Dankwoord 118

9 Promoveren doe je niet alleen. Veel mensen hebben direct of indirect bijgedragen aan de totstandkoming van mijn proefschrift. In de eerste plaats wil ik alle patiënten bedanken die aan de verschillende studies hebben deelgenomen. Tijdens een van de meest speciale momenten in het leven, waren jullie bereid een cruciale bijdrage te leveren aan dit onderzoek. In de tweede plaats, alle mede auteurs voor jullie geweldige bijdrage. Daarnaast alle medewerkers van de centra waar de studies hebben gelopen (afdeling verloskunde LUMC en afdeling verloskunde van ziekenhuis Bronovo) voor hun hulp bij de uitvoering van de studies en het verzamelen van de data. De vakgroep gynaecologie Haga Ziekenhuis, waar ik mijn opleiding heb gedaan en waar ik bovendien vanaf 2017 zelf deel van zal uitmaken. De vakgroep gynaecologie Ikazia Ziekenhuis, mijn collega s tijdens het laatste deel van het promotie onderzoek. Een paar mensen wil ik graag met name noemen. Veel dank voor jullie adviezen, ideeën, kennis, steun en vriendschap. Evert van Rijssel, mijn oud-opleider. Bart Hellebrekers, mijn oud-opleider. Maaike Spaans, mijn opleidingsmaatje en paranimf. Amanda Simon, mijn altijd-steun-en-toeverlaat. Lisette van den Eshof, voor je steun en creatieve inbreng. Anja Kroese, voor je luisterend oor. Saskia Gardeniers, voor je geweldige hulp. In het bijzonder veel dank aan: Robert Verwey, bedankt voor je visie, je inzicht en je deskundige hulp bij het opzetten van de eerste onderzoeken. Ik ben dankbaar dat je me destijds op dit spoor hebt gezet en in contact hebt gebracht met Ruud. Ruud Stientra, de initiator van dit hele project. Ontzettend bedankt voor je vertrouwen, je betrokkenheid en je begeleiding bij de verschillende onderzoeken, maar ook voor de gezellige lunches tussendoor. Albert Dahan, veel dank voor je inzet, snelle reacties en je kritische blik. Ik heb je hulp zeer gewaardeerd. Chapter 9 119

10 Jan van Lith en Annemieke Middeldorp, dank voor jullie waardevolle begeleiding op de juiste momenten. Bas Torrenga, mijn maatje in het Ikazia, dank voor alle gezellige momenten, je steun en je (ongevraagde) adviezen. Lieve (schoon)familie, veel dank voor jullie interesse, motivatie en ondersteuning! Fijn dat jullie altijd voor ons klaar staan. Erwin Douma, lieve grote broer, ontzettend leuk dat je mijn paranimf wil zijn. Liefste Casper, jij zorgde niet alleen voor de belangrijke mentale ondersteuning, maar kwam op met oplossingen voor lastige statistiek problemen, vastgelopen computers, Excel en Word handigheidjes en hielp met mooie plaatjes. Je hebt zelfs een programma voor me laten ontwikkelen om mijn eindeloze stroom van data uit te kunnen lezen. Ik moet daarom toegeven: zonder jou was het niet gelukt. Ik ben ontzettend blij met jou en met ons mooie gezinnetje. 120

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