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1 Cover Page The handle holds various files of this Leiden University dissertation. Author: Kusters, Maria Antonia Adriana (Maaike) Title: Adaptive immune system and vaccination responses in Down syndrome Issue Date:
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3 12 CURRICULUM VITAE LIST OF PUBLICATIONS LIST OF ABBREVIATIONS
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5 CURRICULUM VITAE Maaike Rekers-Kusters werd op 6 februari 1981 geboren in het Brabantse Rijkevoort. Maaike woont in Lent, en heeft een heerlijke tuin die ze deelt met haar man André Rekers, de man achter de schermen bij dit proefschrift! Haar favoriete film is Le fabuleux destin d Amélie Poulain. 12 Maaike wist al op jonge leeftijd dat ze dokter wilde worden, hoewel plantkunde, design en architectuur haar ook trokken. Wat voor een dokter, dat was toen nog niet duidelijk. De Aha-erlebnis kwam bij het co-assistentschap Kindergeneeskunde in het Tweesteden-ziekenhuis in Tilburg, met name door het aanstekelijke enthousiasme en de tomeloze toewijding van dokter Jaap van Lier. De eerste stappen in de kindergeneeskunde werden gezet in het Maxima Medisch Centrum in Veldhoven en het Jeroen Bosch Ziekenhuis s-hertogenbosch als artsassistent niet in opleiding (ANIOS). In 2010 kon worden gestart met de opleiding tot kinderarts (opleider T. Mulder) in het MUMC + in Maastricht, de tweede helft van de opleiding wordt vervolgd in het Radboudumc (opleider J. Draaisma) in Nijmegen. Curriculum Vitae Het wetenschappelijk onderzoek werd verricht naast haar full-time klinische werkzaamheden, met als uitvalsbasis het Jeroen Bosch Ziekenhuis onder de bezielende leiding van Dr. Esther de Vries. Na haar opleiding tot kinderarts wil Maaike zich verder specialiseren binnen de immunologie, een tak van sport waar Maaike zeer gepassioneerd over is. 163
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7 LIST OF PUBLICATIONS 1. Kusters MA, Verstegen RH, Gemen EF, de Vries E. Intrinsic defect of the immune system in children with Down syndrome: a review. Clin Exp Immunol 2009; 156 (2): Verstegen RH, Kusters MA, Gemen EF, de Vries E. Down syndrome B-lymphocyte subpopulations, intrinsic defect or decreased T-lymphocyte help? Pediatr Res 2010; 67 (5): Kusters MA, Gemen EF, Verstegen RH, Wever PC, de Vries E. Both normal memory counts and decreased naive cells favor intrinsic defect over early senescence of Down syndrome T- lymphocytes. Pediatr Res 2010; 67 (5): Kusters MA, Jol-Van der Zijde CM, van Tol MJ, Bolz WE, Bok LA, Visser M, de Vries E. Impaired avidity maturation after tetanus toxoid booster in children with Down syndrome. Pediatr Infect Dis J 2011; 30 (4): List of Publications 5. Kusters MA, Jol-Van der Zijde CM, Gijsbers RH, de Vries E. Decreased response after conjugated meningococcal serogroup C vaccination in children with Down syndrome. Pediatr Infect Dis J 2011; 30 (9): Kusters MA, Verstegen RH, de Vries E. Down syndrome: is it really characterized by precocious immunosenescence? Aging Dis 2011; 2 (6): Kusters MA, Bok VL, Bolz WE, Huijskens EG, Peeters MF, de Vries E. Influenza A/H1N1 vaccination response is inadequate in Down syndrome children when the latest cut-off values are used. Pediatr Infect Dis J 2012; 31 (12): Kusters MA, Manders NC, de Jong BA, van Hout RW, Rijkers GT, de Vries E. Functionality of the pneumococcal antibody response in Down syndrome subjects. Vaccine 2013; 31(52):
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9 LIST OF ABBREVIATIONS Ad-REF Reference values from healthy adults ADHS Antibody diluted human serum AMC Age-matched control BD Becton Dickinson CD Cluster of differentiation CMV cytomegalovirus CSR Class switch recombination CVID Common variable immunodeficiency disorders DGS DiGeorge syndrome DS Down syndrome DSCAM Down syndrome cell adhesion molecule ELISA Enzyme-linked immunosorbent assay ENT Ear-nose-throat FACS Fluorescence-activated cell sorting FI Fold Increase FITC Fluorescein isothiocyanate GALT Gut-associated lymphoid tissue GMT Geometric mean titer HBsAg Hepatitis B surface antigen HI Hemagglutination-inhibition HIV Human immunodeficiency virus ICAM-1 Intercellular adhesion molecules-1 IFN Interferon Ig Immunoglobulin IL Interleukin IPD Invasive pneumococcal disease KREC kappa-deleting recombination excision circles LFA-1 Lymphocyte function-associated antigen-1 MAb Monoclonal antibodies MALT Mucosa-associated lymphoid tissue MenC Meningococcal serogroup C conjugate vaccine MFI Mean fluorescence intensity NK Natural killer OPA Opsonophagocytosis assay PCV-7 Heptavalent pneumococcal conjugate vaccine PE phycoerythrin PE-Cy5 PE-cyanin 5 PHA Phytohemagglutinin PI Phagocytosis index PPV valent pneumococcal polysaccharide vaccine RPMI Roswell Park Memorial Institute medium RTE Recent thymic emigrants SHM Somatic hypermutation SPAD Specific anti-polysaccharide antibody deficiency Tc Cytotoxic T TD T-cell dependent Th Helper-T TI T-cell independent TNF Tumour necrosis factor TREC T-cell-receptor excision circle TT Tetanus Toxoid 12 List of Abbreviations 167
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Cover Page. The handle holds various files of this Leiden University dissertation.
Cover Page The handle http://hdl.handle.net/1887/43530 holds various files of this Leiden University dissertation. Author: Stijntjes, M. Title: Interactions of cognitive and physical ageing Issue Date:
Nadere informatiePublications PUBLICATIONS
Publications 164 Publications PUBLICATIONS 1. Heemskerk B, Veltrop-Duits LA, van Vreeswijk T, ten Dam MM, Heidt S, Toes RE, van Tol MJ, Schilham MW. Extensive cross-reactivity of CD4 + adenovirus-specific
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