Impact of age, tumor characteristics, an d treatmen t on local con trol an d disease outcome in early stage breast can cer.

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1 06 Prfschrft JvdH Binnenwerk :06 Pagina 1 Impact of age, tumor characteristics, an d treatmen t on local con trol an d disease outcome in early stage breast can cer. A n EO RT C tran slation al research project Jos Alexander van der Hage 1

2 06 Prfschrft JvdH Binnenwerk :06 Pagina 2 Cover: Annebeth van der Hage 2

3 06 Prfschrft JvdH Binnenwerk :06 Pagina 3 Impact of age, tumor characteristics, and treatment on local control and disease outcome in early stage breast cancer. An EORTC translational research project PROEFSCH RIFT ter verkrijging van de graad van D octor aan de U niversiteit Leiden, op gezag van de R ector M agnificu s D r.d.d.breim er, hoogleraar in de facu lteit der W isku nde en N atu u rw etenschappen en die der G eneesku nde, volgens beslu it van het College voor Prom oties te verdedigen op m aandag 22 m ei 2006 te klokke u u r door Jos Alexander van der Hage G eboren te Hilversu m in

4 06 Prfschrft JvdH Binnenwerk :06 Pagina 4 PROMOTIECOMMISSIE Promotores: Co-promotor: Referent: Overige leden: Prof. Dr. C.J.H. van de V elde Prof. Dr. G.J. Fleuren Dr. M.J. van de V ijver Prof. Dr. J.W.R. Nortier Prof. Dr. R.A.E.M. Tollenaar Prof. Dr. H. Bartelink Dr. E.J.Th. Rutgers Dr. P. Therasse Part of this work was financially supported by the K oningin Wilhelmina Fonds (K WF). Publication of this thesis was financially supported by Abbott Nutrition International, AstraZ eneca BV, familie van der Hage, Integraal K ankercentrum West (IK W), Johnson & Johnson Medical BV, K CI Medical BV, Novartis Pharma BV, Pfizer, Sanofi Aventis, Tyco Healthcare BV Production: Sagittarius ontwerpen, Gouda 4

5 06 Prfschrft JvdH Binnenwerk :06 Pagina 5 Aan mijn ouders, voor Léontine, Annebeth en Josephine 5

6 06 Prfschrft JvdH Binnenwerk :06 Pagina 6 CONTENTS Chapter G eneral introduction PART I Chapter Improved survival after one course of perioperative chemotherapy in early breast cancer patients. Long-term results from the European Organization for Research and Treatment of Cancer (EORTC) Trial VAN D ER HAG E JA, VAN D E VELD E CJ, JU LIEN JP, FLOIRAS JL, D ELOZIER T, VAND ERVELD EN C, D U CHATEAU L. EUR J CANCER NOV;37(17): Chapter Preoperative chemotherapy in primary operable breast cancer: results from the European Organization for Research and Treatment of Cancer trial VAN D ER HAG E JA, VAN D E VELD E CJ, JU LIEN JP, TU BIANA-HU LIN M, VAND ERVELD EN C, D U CHATEAU L. J CLIN ONCOL NOV 15;19(22): Chapter Clinical Tumor Response to Anthracycline Containing Preoperative Chemotherapy in W omen w ith Early Stage Breast Cancer: the Predictive Role of P53 Expression. MIEOG SJD, VAN D ER HAG E JA, VAN D E VIJVER MJ, VAN SLOOTEN H-J, ELK HU IZEN P, PU TTER H, VAN D E VELD E CJH, AND COOPERATING INVESTIG ATORS OF THE EORTC. ACCEPTED FOR PUBLICATION IN THE EUROPEAN JOURNAL OF CANCER PART II Chapter Overexpression of P70 S6 kinase protein is associated w ith increased risk of locoregional recurrence in node-negative premenopausal early breast cancer patients. VAN D ER HAG E JA, VAN D EN BROEK LJ, LEG RAND C, CLAHSEN PC, BOSCH CJ, ROBANU S-MAAND AG EC, VAN D E VELD E CJ, VAN D E VIJVER MJ. BR J CANCER APR 19;90(8):

7 06 Prfschrft JvdH Binnenwerk :06 Pagina 7 Chapter Impact of locoregional treatment on the early-stage breast cancer patients: a retrospective analysis. VAN DER HAGE JA, PUTTER H, BONNEMA J, BARTELINK H, THERASSE P, VAN DE VELDE CJ; EORTC BREAST CANCER GROUP. EUR J CANCER OCT;39(15): Chapter Breast conserving therapy and young age are both independent prognostic factors associated with isolated loco-regional recurrences in early stage breast cancer. DE BOCK GH, VAN DER HAGE JA, PUTTER H, BONNEMA J, BARTELINK H, VAN DE VELDE CJH. EUR J CANCER FEB 42(3); PART III Chapter Impact of established prognostic factors in early stage breast cancer in very young breast cancer patients; a translational research project using pooled datasets derived from 4 EORTC Breast Group Trials. VAN DER HAGE JA, VAN DE VELDE CJH, PUTTER H, BARTELINK H, VAN DE VIJVER MJ, ON BEHALF OF THE EORTC BREAST CANCER GROUP. Chapter Efficacy of adjuvant chemotherapy according to hormone receptor status in young breast cancer patients. VAN DER HAGE JA, VAN DE VIJVER MJ, PUTTER H, THERASSE P, VAN DE VELDE CJH, AND COOPERATING INVESTIGATORS OF THE EUROPEAN ORGANIZATION FOR RESEARCH AND TREATMENT OF CANCER (EORTC). SUBMITTED Chapter General Discussion Chapter Summary Chapter Summary in Dutch 7

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