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1 Cover Page The handle holds various files of this Leiden University dissertation. Author: Groeneveld, Dafna Jordana Title: On the miscellaneous aspects of von Willebrand factor Issue Date:

2 Publications 1. Lisman T, Raynal N, Groeneveld D, Maddox B, Peachey AR, Huizinga EG, de Groot PG, Farndale RW. A single high-affinity binding site for von Willebrand factor in collagen III, identified using synthetic triple-helical peptides. Blood 2006;108(12): Westerweel PE, Hoefer IE, Blankestijn PJ, de Bree P, Groeneveld D, van Oostrom O, Braam B, Koomans HA, Verhaar MC. End-stage renal disease causes an imbalance between endothelial and smooth muscle progenitor cells. Am J Physiol Renal Physiol 2007;292(4):F Groeneveld D, Eikenboom J. Von Willebrand Disease Hematology Education 2011 (5): Wang JW, Groeneveld DJ, Cosemans G, Dirven RJ, Valentijn KM, Voorberg J, Reitsma PH, Eikenboom J. Biogenesis of Weibel-Palade bodies in von Willebrand s disease variants with impaired von Willebrand factor intrachain or interchain disulfide bond formation. Haematologica 2012 Jun;97(6): Groeneveld DJ, Wang JW, Mourik MJ, Dirven RJ, Valentijn KM, Voorberg J, Reitsma PH, Eikenboom J. Storage and secretion of naturally occurring of von Willebrand factor A domain variants. Br J Haematol 2014;167(4): Groeneveld D, Porte RJ, Lisman T. Thrombomodulin-modified thrombin generation testing detects a hypercoagulable state in patients with cirrhosis regardless of the exact experimental conditions. Thromb Res 2014;134(3): Sanders YV, Groeneveld D, Meijer K, Fijnvandraat K, Cnossen MH, van der Bom JG, Coppens M, de Meris J, Laros-van Gorkom BA, Mauser-Bunschoten EP, Leebeek FW, Eikenboom J. Von Willebrand factor propeptide and the phenotypic classification of von Willebrand disease. Blood 2015;125(19): Groeneveld DJ, van Bekkum T, Cheung KL, Dirven RJ, Castaman G, Reitsma PH, van Vlijmen B, Eikenboom J. No evidence for a direct effect of von Willebrand factor s ABH blood group antigens on von Willebrand factor clearance. J Thromb Haemost 2015;13(4): Groeneveld DJ, van Bekkum T, Dirven RJ, Wang JW, Voorberg J, Reitsma PH, Eikenboom J. Angiogenic characteristics of blood outgrowth endothelial cells from patients with von Willebrand disease. J Thromb Haemost 2015; in press. 181

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4 Acknowledgement You know how it is. You pick up a dissertation, flip through the pages right to the acknowledgements, and find that, once again, the author has thanked numerous people, except you. Not this time. Because we haven t yet met/have only a glancing acquaintance/are just crazy about each other/haven t seen each other in much too long/ are in some way related/worked together/will never meet, but will, I trust, despite that, always think fondly of each other. This one s for you. With you know what, and you probably know why. ~ Adapted from Anansi Boys by Neil Gaiman, 2005 ~ 183

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6 Curriculum Vitae Dafna J. Groeneveld werd geboren op 9 November 1982 te Steenwijk en behaalde in 2001 haar HAVO diploma aan de Thorbecke Scholengemeenschap (Zwolle). In datzelfde jaar begon zij aan de opleiding Biologie en medisch laboratoriumonderzoek aan het Saxion Hogeschool IJsselland (Deventer) met als specialisatie klinische chemie. Vanaf 2003 heeft ze drie stages gelopen. Haar eerste stage werd uitgevoerd op het laboratorium voor klinische chemie van het Meander Medisch Center (Amersfoort). Haar tweede stage volbracht zij bij de afdeling experimentele klinische chemie van het Academisch Medisch Centrum (Amsterdam) waar zij onder leiding van prof. dr. A. Sturk en dr. M. Peters onderzoek deed naar de betrouwbaarheid van de bloedingstijd en de Platelet Function Analyzer voor het detecteren van bloedingsneigingen. Haar afstudeerstage van 9 maanden volbracht zij onder leiding van prof. dr. T. Lisman bij de afdeling Trombose en Hemostase van het Universitair Medisch Centrum Utrecht waar zij werkte aan het identificeren van de bindingsplaats voor von Willebrand factor in collageen. Na het behalen van haar bachelor diploma in juli 2005 heeft zij een jaar als research analist gewerkt bij de afdeling Vasculaire Geneeskunde van het UMC Utrecht, waar ze de rol van endotheel- en gladde spier voorlopercellen in patiënten met eindstadium nierfalen onderzocht. In september 2006 begon zij aan de opleiding Forensic Science aan de Universiteit van Amsterdam. Haar master thesis No enemy is worse than bad advice: a framework for validating forensic advice was het resultaat van 6 maanden onderzoek bij de Forensische Samenwerking in de Opsporing (FSO, locatie Midden Nederland), een samenwerkingsverband tussen de politie en het Nederlands Forensisch Instituut. Na het behalen van haar masterdiploma, begon zij eind 2008 met haar promotieonderzoek bij de afdeling Trombose en Hemostase, onderdeel van het Einthoven Laboratorium voor Experimentele Vasculaire Geneeskunde, in het Leids Universitair Medisch Centrum. Onder begeleiding van prof. dr. H.C.J. Eikenboom deed zij onderzoek naar verschillende aspecten van het stollingseiwit von Willebrand factor. De resultaten beschreven in dit proefschrift zijn op verschillende (inter)nationale congressen gepresenteerd en in 2012 ontving zij de NVTH award for scientific excellence in biochemical research van de Nederlandse Vereniging voor Trombose en Hemostase. Sinds november 2013 is zij werkzaam als post-doc bij de afdeling Chirurgisch Onderzoekslaboratorium van het Universitair Medisch Centrum Groningen. Onder begeleiding van prof. dr. R.J. Porte en prof. dr. T. Lisman werkt zij aan zowel klinische als fundamentele aspecten op het snijvlak van hematologie, hepatologie en chirurgie. Ze heeft als co-applicant zowel een beurs binnen gehaald van de Nederlandse Trombosestichting als de Grifols Antithrombin Research Award. 185

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