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1 Cover Page The handle holds various files of this Leiden University dissertation Author: Poortvliet, Rosalinde Title: New perspectives on cardiovascular risk prediction in old age Issue Date:

2 Bibliography Bibliography 1. Poortvliet RK, Ford I, Lloyd SM, et al. Blood Pressure Variability and Cardiovascular Risk in the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER). PLoS One. 2012;7(12):e Sabayan B, Oleksik AM, Maier AB, et al. High blood pressure and resilience to physical and cognitive decline in the oldest old: the Leiden 85-plus Study. J Am Geriatr Soc. 2012;60(11): Poortvliet RK, de Ruijter W, de Craen AJ, et al. Blood pressure trends and mortality: the Leiden 85-plus Study. J Hypertens. 2013;31(1): Poortvliet RK, Blom JW, de Craen AJ, et al. Low blood pressure predicts increased mortality in very old age even without heart failure: the Leiden 85-plus Study. Eur J Heart Fail. 2013;15(5): Drewes YM, Poortvliet RK, Blom JW, et al. Homocysteine levels and treatment effect in the prospective study of pravastatin in the elderly at risk. J Am Geriatr Soc. 2014;62(2): van Vliet P, Sabayan B, Wijsman LW, et al. NT-proBNP, blood pressure, and cognitive decline in the oldest old: The Leiden 85-plus Study. Neurology. 2014;83(13): Wijsman LW, Sabayan B, van Vliet P, et al. N-terminal pro-brain natriuretic peptide and cognitive decline in older adults at high cardiovascular risk. Ann Neurol. 2014;76(2): Barnhoorn P, Poortvliet RK. Dipstick en urineweginfecties bij vrouwen. Huisarts Wet. 2014;8: Poortvliet RK, Lloyd SM, Ford I, et al. Biological Correlates of Blood Pressure Variability in Elderly at High Risk of Cardiovascular Disease. Am J Hypertens. 2015;28(4): Poortvliet RK, Drewes Y. Homocysteïnespiegel en cardiovasculair risico. Huisarts Wet. 2015;6: Tomaes LC, Poortvliet RK, Kwint HF, Gussekloo J. [Medication review in older people: identification of a new risk group]. Ned Tijdschr Geneeskd. 2015;159(0):A

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4 Dankwoord Dankwoord Onderzoek doe je niet alleen. Zonder de steun, inspiratie en kritische blikken van velen om mij heen was dit proefschrift nooit tot stand gekomen. Dit dankwoord geeft mij de gelegenheid iedereen te bedanken die op enige wijze bij dit onderzoek betrokken is geweest. Naast het eigenlijke werk tijdens het promotietraject is de plek waar je werkt voor mij minstens zo belangrijk gebleken. Daarom wil ik ook alle collega s van de afdeling Public Health en Eerstelijnsgeneeskunde van het LUMC bedanken voor de fijne werksfeer, inspirerende gesprekken, hun enthousiasme en hun betrokkenheid. Een aantal mensen wil ik nog in het bijzonder noemen. Wendy, samenwerken aan TRUST gaf een andere dimensie aan het werk als onderzoeker. Wat een fijne collega was je en een lieve vriendin ben je. Jeanet, Petra en Yvonne, onderzoek op het gebied van cardiovasculaire ziekten bij ouderen leverde ons vanaf het begin een betekenisvolle band op, nu is er zo veel meer. Bedankt dat jullie er zijn. De onderzoeksperiode in Glasgow heeft mijn wetenschappelijke blik verruimd. Dear David, thank you for your support to come to Glasgow. I am grateful for the opportunity to work with you and your team. Our collaboration was and is inspiring and intellectually stimulating for me. Om een promotietraject tot een succesvol einde te brengen is een goede samenwerking met promotor en co-promotor essentieel. Jacobijn, jouw kritische wetenschappelijke blik heeft mij gestimuleerd. Jij steunde mij niet alleen op wetenschappelijk, maar ook op persoonlijk vlak. Ik ben blij dat wij voorlopig nog samen kunnen blijven werken. Wouter, wat heb jij mij veel geleerd de afgelopen jaren. Mijn promotietraject in combinatie met de huisartsopleiding vergde hier en daar behoorlijk wat flexibiliteit en jij steunde mij daarin. Door jou ben ik de afgelopen jaren gegroeid in mijn werk als onderzoeker. Jouw enthousiasme voor het vak is aanstekelijk. Mijn ex-promotor Pim wil ik ook bedanken. Jouw visie op de huisartspraktijk was een aanvulling tijdens het begin van mijn promotietraject. Daarnaast wil ik mijn dank betuigen aan de leden van mijn promotiecommissie prof. dr. Yvo Smulders, prof. dr. Theo Stijnen en dr. Eric Moll van Charante voor de tijd die zij vrij wilden maken om mijn proefschrift te beoordelen en met mij van gedachten te willen wisselen tijdens de verdediging ervan. Al mijn opleiders, huisartsbegeleiders en gedragswetenschappers van de huisartsopleiding wil ik bedanken voor de ruimte die zij mij hebben gegeven om naast mijn opleiding ook mijn promotieonderzoek voort te zetten. In het bijzonder wil ik Paul Jonas en Ans 171

5 Dankwoord van der Salm bedanken. Paul, aan het einde van mijn eerste jaar in de huisartsenopleiding heb jij mij het laatste zetje gegeven te gaan solliciteren voor de AIOTHO plek. Ans, bij jou in de praktijk ben ik echt de huisarts-onderzoeker geworden die ik nu ben. Daarnaast wil ik de SBOH bedanken voor de mogelijkheid mijn promotieonderzoek te combineren met de opleiding tot huisarts. Antonette, wat bijzonder dat ik jouw paranimf mocht zijn en wat fijn dat jij mijn paranimf wilt zijn op deze dag. Wat hebben wij samen gezwoegd op onze kamer. Bedankt voor alles. Lieve Yorick, ik ben blij dat jij mij als paranimf bij wilt staan. Ik ben er trots op jouw zus te zijn. Wij steunen elkaar door dik en dun en dat vind ik heel bijzonder. Bedankt voor het mooie ontwerp van de omslag van mijn proefschrift, dit betekent veel voor mij. Lieve pap en mam, dank voor jullie onvoorwaardelijke steun en vertrouwen. Jullie hebben mij altijd gestimuleerd om mijn ambities waar te maken. Wat fijn om te beseffen dat ik uit zo n warm nest kom. Bedankt dat jullie er altijd voor mij zijn. Familie en vrienden, bedankt voor jullie interesse, steun en vertrouwen. Bij jullie vond ik de ontspanning en het klankbord dat ik nodig had. Oma s en opa, wat bijzonder dat jullie dit nog mee mogen maken. En ten slotte natuurlijk Remco, wat een geluk dat jij in mijn leven bent gekomen. Bedankt voor jouw steun, betrokkenheid en de ruimte die jij mij geeft mijn ambities waar te maken. Wat fijn dat jij mij daarin begrijpt en dat wij er voor elkaar zijn. 172

6 Curriculum vitae Curriculum vitae Rosalinde Poortvliet was born on February in Aalsmeer, the Netherlands. She passed her Gymnasium examination at the Nieuwer Amstel in Amstelveen in She studied Biomedical Sciences at Leiden University Medical Center from 1999 through In 2001 she started medical school at the University of Leiden where she obtained her medical degree in Subsequently, she worked as a resident at the Department of Psychiatry at GGZ ingeest ( ). Between 2009 and 2013 she completed her vocational training for general practice at the Department of Public Health and Primary Care of the Leiden University Medical Center. During this vocational training, in 2010, she started the research project described in this thesis at the same department. In 2011 she worked for three months at the Academic Section of Geriatric Medicine (University of Glasgow, Faculty of Medicine, Glasgow, UK). From 2013 onwards she worked as a parttime general practitioner. At present, she works as a general practitioner in Huisartsencentrum Hillegersberg in the city of Rotterdam. At the Department of Public Health and Primary Care of the Leiden University Medical Center she continues her clinical research into cardiovascular disease (ECSTATIC) and thyroid dysfunction in old age (TRUST and IEMO 80-plus). She is currently completing her Master of Epidemiology. 173

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