University of Groningen Isolated limb infusion Kroon, Hidde Maarten IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below. Document Version Publisher's PDF, also known as Version of record Publication date: 2009 Link to publication in University of Groningen/UMCG research database Citation for published version (APA): Kroon, H. M. (2009). Isolated limb infusion s.n. Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons). Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum. Download date: 28-09-2017
Isolated Limb Infusion Hidde M. Kroon
This thesis is based on studies performed at the University of Michigan Comprehensive Cancer Center, Ann Arbor, U.S.A. and the Sydney Melanoma Unit, Australia. The laboratory and clinical studies included in this thesis were financially supported by: Stichting Prof. Michaël-van Vloten Fonds, Haak Bastiaanse-Kuneman Stichting, Stichting Sacha Swarttouw-Heijmans, KWF Kankerbestrijding, the Gillson Longenbaugh Foundation, Dr. Saal van Zwanenbergstichting, Buwalda Stichting, Dr. Hendrik Muller s Vaderlandsch Fonds, Jan Kornelis de Cock-Stichting, Stichting Groninger Universiteitsfonds, Marco Polo Fonds, Schuurman Schimmel-van Outeren Stichting, Fundatie van de Vrijevrouwe van Renswoude te Delft, Stichting Fundatie van de Vrijvrouwe van Renswoude te s-gravenhage, Amgen Nederland BV, NIH grants CA82529 and CA69102, the Melanoma Foundation of the University of Sydney and Melanoma Institute Australia, Universitair Medisch Centrum Groningen / Faculteit der Medische Wetenschappen Rijksuniversiteit Groningen. The printing of this thesis was kindly supported by: Stichting Nationaal Fonds tegen Kanker voor onderzoek naar reguliere en aanvullende therapieën te Amsterdam, Guide Groningen, J.E. Jurriaanse Stichting, Wyeth Pharmaceuticals bv, Stichting Melanoom, Maquet Netherlands B.V. Cardiovascular, KCI Medical BV Copyright 2009, Hidde Kroon, Amsterdam, the Netherlands All rights reserved. No part of this thesis may be reproduced, stored in a retrieval system or transmitted in any form or by any means, without prior permission of the author. Cover: Windkracht 14 door Pépé Grégoire Foto: Hidde Kroon Design and lay-out: Chris Bor, Medical Photography and Illustration, Academic Medical Center, Amsterdam, the Netherlands Printed by: Buijten & Schipperheijn, Amsterdam, the Netherlands ISBN: Book: 978-90-367-3800-2 Digital edition: 978-90-367-3801-9
RIJKSUNIVERSITEIT GRONINGEN Isolated Limb Infusion Proefschrift ter verkrijging van het doctoraat in de Medische Wetenschappen aan de Rijksuniversiteit Groningen op gezag van de Rector Magnificus, dr. F. Zwarts, in het openbaar te verdedigen op maandag 18 mei 2009 om 13:15 uur door Hidde Maarten Kroon geboren op 22 juli 1978 te Rotterdam
Promotores Prof. dr. H.J. Hoekstra Prof. dr. J.F. Thompson Prof. dr. A.E. Chang Beoordelingscommissie Prof. dr. A.M.M. Eggermont Prof. dr. J.Th.M. Plukker Prof. dr. Th. Wobbes
There are known knowns, these are things we know that we know. There are known unknowns, that is to say, there are things that we know we don t know. But there are also unknown unknowns, these are things we don t know we don t know. Donald Rumsfeld Aan mijn ouders
Table of Contents Introduction and outline of the thesis 9 Part I: Chapter 1 Chapter 2 Chapter 3 Chapter 4 Chapter 5 Chapter 6 Chapter 7 Chapter 8 Isolated limb infusion for melanoma and soft tissue sarcoma Outcomes following isolated limb infusion for melanoma. A 14-year experience Annals of Surgical Oncology 2008;15:3003-13 Factors predictive of acute regional toxicity after isolated limb infusion with melphalan and actinomycin-d in melanoma patients (with editorial) Annals of Surgical Oncology; Epub ahead of print Safety and efficacy of isolated limb infusion with cytotoxic drugs in elderly patients with advanced locoregional melanoma Annals of Surgery; in press Isolated limb infusion as palliative treatment for advanced limb disease in patients with AJCC stage IV melanoma Annals of Surgical Oncology; Epub ahead of print Efficacy of repeat isolated limb infusion with melphalan and actinomycin-d for recurrent melanoma Cancer; Epub ahead of print Major amputation for irresectable extremity melanoma after failure of isolated limb infusion Annals of Surgical Oncology; in press Isolated limb infusion for advanced soft tissue sarcoma of the extremity Annals of Surgical Oncology 2008;15:2749-56 Isolated limb infusion: A review Journal of Surgical Oncology; in press 23 45 65 79 95 111 121 137
Part II: Chapter 9 Adoptive immunotherapy for cancer 4-1BB costimulation of effector T-cells for adoptive immunotherapy of cancer: Involvement of Bcl gene family members Journal of Immunotherapy 2007;30:406-16 161 Summary and conclusions 183 Samenvatting en conclusies 191 Future perspectives 201 Appendix Isolatie-infusie effectief bij melanoom en sarcoom. Goed alternatief voor regionale isolatieperfusie met cytostatica Nederlands Tijdschrift voor Geneeskunde 2009;153:508-14 209 Publications 221 Presentations 225 Dankwoord 231 Curriculum vitae 239