COPD Liesker, Jeroen Johannes Wilhelmus IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below. Document Version Publisher's PDF, also known as Version of record Publication date: 2008 Link to publication in University of Groningen/UMCG research database Citation for published version (APA): Liesker, J. J. W. (2008). COPD: a multifaceted disease s.n. Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons). Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum. Download date: 01-02-2017
COPD A MULTIFACETED DISEASE JEROEN J.W. LIESKER
CIP-GEGEVENS KONINKLIJKE BIBLIOTHEEK, DEN HAAG Liesker, J.J.W. COPD - a multifaceted disease Proefschrift Groningen. - Met lit. opg. - Met samenvatting in het Nederlands. ISBN-13 978-90-75092-50-9 Copyright 2008 J.J.W. Liesker All rights are reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, mechanically, by photocopying, recording, or otherwise, without the written permission of the author. Cover design: J.J.W. Liesker, Groningen NL Skyline Groningen: R. Franke, Bedum NL Layout: Kader Desktop Publishing, Annen NL Printed by: Drukkerij Gildeprint, Enschede NL
COPD A MULTIFACETED DISEASE Proefschrift ter verkrijging van het doctoraat in de Medische Wetenschappen aan de Rijksuniversiteit Groningen op gezag van de Rector Magnificus, dr. F. Zwarts, in het openbaar te verdedigen op woensdag 7 mei 2008 om 16:15 uur door Jeroen Johannes Wilhelmus Liesker geboren op 5 november 1970 te Arnhem
Promotores: Copromotor: Beoordelingscommissie: Prof. dr. H.A.M. Kerstjens Prof. dr. D.S. Postma Prof. dr. W. Timens Dr. N.H.T. Ten Hacken Prof. dr. J. Vestbo Prof. dr. T. van der Molen Prof. dr. H.F. Kauffman
Paranimfen: Dhr. M.P. Bogaards Dhr. J. van der Zwaag This thesis is based on research performed within: The clinical trials described in this thesis were financially supported by AstraZeneca, the Netherlands and Netherlands Asthma Foundation. Publication of this thesis was generously supported by: AstraZeneca BV, Bayer BV, Boehringer-Ingelheim BV, Chiesi Pharmaceuticals BV, GlaxoWellcome, Graduate School GUIDE, Meda Pharma BV, Netherlands Asthma Foundation, Novartis Pharma BV, Nycomed BV, Rijksuniversiteit Groningen, Roche Nederland BV, Schering-Plough, Stichting Astma Bestrijding, Zambon Nederland BV. Their support is gratefully acknowledged.
Voor mijn ouders
CONTENTS Chapter 1 Chapter 2 Chapter 3 Chapter 4 Chapter 5 Chapter 6 Chapter 7 Chapter 8 Chapter 9 Chapter 10 Chapter 11 Introduction Sputum inflammation predicts COPD exacerbations after discontinuation of inhaled corticosteroids in mild-to-moderate COPD Submitted Cessation of inhaled steroids worsens sputum eosinophils and lung function in stable COPD Submitted Anti-inflammatory effects of combined budesonide/formoterol in COPD exacerbations Submitted Effects of formoterol (Oxis Turbuhaler) and ipratropium on exercise capacity in patients with COPD Respir Med. 2002;96:559-66 A systematic review of the effects of bronchodilators on exercise capacity in patients with COPD Chest. 2002;121:597-608 Subepithelial basement membrane in asthma and COPD: similar thickness, yet different composition Submitted Mast cell numbers in airway smooth muscle and PC 20AMP in asthma and COPD Respir Med. 2007;101:882-7 Cognitive performance in patients with COPD Respir Med. 2004;98:351-6 Summary, conclusions, and recommendations Nederlandse samenvatting voor niet medisch geschoolden Dankwoord Curriculum Vitae List of co-authors 8 20 40 56 78 90 114 128 140 152 164 178 184 188