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Acknowledgements Acknowledgements This study was supported by an unrestricted grant of the Netherlands Organization for Scientific Research (NWO 940-31-049), and by the "Doelmatigheidsfonds van het LUMC" (LUMC fund to increase efficiency in healthcare). I would like to thank the following GPs and their patients for their participation: K.F. van de Bent, A. Boels, J.J.F.M. Brinkmann, T. Buiter-van der Kooi, H.A. Dirkse, L.van Duijn, F.M.M. van Exter, F.G.W.M. Haase, H. van Klei, J. Klein Haneveld, W. Libeton, C.H. Luirink, E.H.J. Smids, M.H.C. van der Velden, R.M. Vermeer, R. Voskuil, P.G. Willemse, and B.W. de Zeeuw. 155

Acknowledgements 156

Publications Publications Wiendels NJ, Knuistingh Neven A, Rosendaal FR, Spinhoven P, Zitman FG, Assendelft WJJ, Ferrari MD. Chronic frequent headache in the general population: prevalence and associated factors. Cephalalgia 2006;26(12):1434-42. Wiendels NJ, van Haestregt A, Knuistingh Neven A, Spinhoven P, Zitman FG, Assendelft WJJ, Ferrari MD. Chronic frequent headache in the general population: comorbidity and quality of life. Cephalalgia 2006;26(12):1443-50. Wiendels NJ and Ferrari MD. Treating Migraine Attacks ASAP: Concept and Methodological Issues. Progress in Neurotherapeutics and Neuropsychopharmacology 2006 Jan;1(1):53-61. Wiendels NJ, van der Geest MC, Neven AK, Ferrari MD, Laan LA. Chronic daily headache in children and adolescents. Headache 2005 Jun;45(6):678-83. Wiendels NJ and Ferrari MD. Chronic Migraine. In: Olesen J. Classification and diagnosis of headache disorders. New York: Oxford University Press, 2005:70-75. ISBN0-19-856590-9. Wiendels NJ en Ferrari MD. Hoe vaak komt medicatieafhankelijke hoofdpijn in Nederland voor? In: Van Meyel AJJM.Vademecum permanente nascholing voor huisartsen. Houten: Bohn Stafleu Van Loghum bv, 2005. ISBN0929-0605. Wiendels NJ en Ferrari MD. Hoe vaak komt medicatieafhankelijke hoofdpijn in Nederland voor? In: Van Meyel AJJM.Vademecum permanente nascholing voor neurologen. Houten: Bohn Stafleu Van Loghum bv, 2005. ISBN0929-0605. Schoonman GG, Wiendels NJ, Ferrari MD. Acupunctuur bij de profylactische behandeling van migraine; voorlopig geen bewijs van effectiviteit. Ned Tijdschr Geneeskd 2004 Oct 30;148(44):2165-6. Wiendels NJ en Ferrari MD. Chronische dagelijkse hoofdpijn (CDH): de rol van overmatig gebruik van hoofdpijnmedicatie en cafeïne. In: Biemond cursus. Multipele sclerose en 157

Publications pijnsyndromen. Utrecht: Nederlandse Vereniging voor Neurologie, 2004:37-48. ISBN90-76756-10-4. Schoonman GG, Wiendels NJ, Ferrari MD. Gabapentin in migraine prophylaxis: is it effective and well tolerated? Headache 2002 Mar;42(3):235. Wiendels NJ, Haan J, Knuistingh Neven A, Ferrari MD. Chronische dagelijkse hoofdpijn en overmatig gebruik van hoofdpijnmedicatie. Modern Medicine 2001;11:1216-1221. Knuistingh Neven A, Haan J, Wiendels NJ, Gulmans J, Ferrari MD. Chronische dagelijkse hoofdpijn en overmatig gebruik van hoofdpijnmedicatie. In: Boerhaave Commissie voor postacademisch onderwijs in de geneeskunde. Zorg om neurologische aandoeningen. Leiden: LUMC, 2001:105-114. ISBN90-6767-475-3. 158

Curriculum Vitae Curriculum Vitae Natalie Janette Wiendels was born in Durban, South-Africa, on February 6, 1973. She attended secondary school at KSG De Breul in Zeist, the Netherlands, and graduated in 1991. She started medical school at Utrecht University and conducted a research project concerning intractable epilepsy at the British Columbia s Children s Hospital in Vancouver, Canada. She obtained her medical degree in 1998 and worked as a resident for one year at the department of neurology at Spaarne Ziekenhuis Haarlem. Until December 2006 she worked as a research-physician at the departments of Neurology and Public Health and Primary Care of Leiden University Medical Center (LUMC) under supervision of prof.dr. Michel D. Ferrari, neurologist, and dr. Arie Knuistingh Neven, general practitioner, which resulted in this thesis. The main focus of her work was on the epidemiology of chronic frequent headache in the general population. The results have been presented on several international headache congresses. She received a review lecture award at the 16 th Migraine Trust International Symposium held in London in 2006. In addition, she set up and conducted two preference trials for the acute treatment of migraine. In January 2007 she started a residency in neurology at Rijnland Ziekenhuis in Leiderdorp, and is currently working at LUMC in Leiden. Natalie Janette Wiendels werd op 6 februari 1973 geboren in Durban, Zuid-Afrika. Ze volgde het VWO, gymnasiumstroom, aan de KSG De Breul in Zeist en slaagde in 1991. Daarna studeerde ze geneeskunde aan de Universiteit Utrecht en deed een wetenschappelijke stage in het British Columbia s Children s Hospital in Vancouver, Canada. Ze behaalde haar artsexamen in 1998 en werkte voor een jaar als arts-assistent op de afdeling neurologie in het Spaarne Ziekenhuis te Haarlem. Van november 1999 t/m december 2006 werkte ze als artsonderzoeker op de afdelingen Neurologie en Public health en Eerstelijnsgeneeskunde van het Leids Universitair Medisch Centrum (LUMC) onder supervisie van prof.dr. Michel D. Ferrari, neuroloog, en dr. Arie Knuistingh Neven, huisarts, wat resulteerde in dit proefschrift. Het hoofdonderwerp van haar promotie onderzoek betrof de epidemiologie van chronisch frequente hoofdpijn in de Nederlandse algemene bevolking. De resultaten heeft zij gepresenteerd op diverse internationale hoofdpijncongressen. In 2006 ontving ze een review lecture award op het 16 e Migraine Trust International Symposium te Londen. Daarnaast heeft zij twee patiëntenvoorkeurstudies voor de acute behandeling van migraine opgezet en uitgevoerd. In januari 2007 begon zij als arts-assistent neurologie in het Rijnland Ziekenhuis te Leiderdorp en sinds juli 2007 in het LUMC te Leiden. 159