Barrett s Esophagus Revisited: Epidemiology, Risk Stratification and Cancer Prevention P.J.P. DE JONGE
ISBN: 978-90-8559-514-4 Financial support for printing this thesis was kindly given by Stichting Nationaal Fonds tegen Kanker -voor onderzoek naar reguliere en aanvullende therapieën te Amsterdam-, J.E. Jurriaanse Stichting, AstraZeneca B.V., Janssen-Cilag B.V., Ferring B.V., Novartis Pharma B.V., Solvay Pharma B.V., Cook Medical B.V., Tramedico B.V., Olympus B.V., Abbott B.V., Pentax Nederland B.V., and the Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam. Lay-out: Optima Grafische Communicatie, Rotterdam Printed by: Optima Grafische Communicatie, Rotterdam Cover: Patrick Hessels, www.recentactivity.com P.J.F. de Jonge, the Netherlands, 2009. All rights reserved. No part of this thesis may be reproduced or transmitted in any form or by any means, without prior permission of the author.
Barrett s Esophagus Revisited: Epidemiology, Risk Stratification and Cancer Prevention Barrett s oesofagus herbezien: epidemiologie, risico stratificatie en kanker preventie PROEFSCHRIFT ter verkrijging van de graad van doctor aan de Erasmus Universiteit Rotterdam op gezag van de rector magnificus Prof.dr. S.W.J. Lamberts en volgens besluit van het College voor Promoties. De openbare verdediging zal plaatsvinden op 20 mei 2009 om 11.45 uur. door Pieter Jan Floris de Jonge geboren te Oud-Beijerland
Promotiecommissie Promotoren: Prof.dr. E.J. Kuipers Prof.dr. P.D. Siersema Overige Leden: Prof.dr. G.A. Meijer Prof.dr. E.W. Steyerberg Prof.dr. H.W. Tilanus
Voor mijn ouders.
Contents Chapter 1 General introduction and outline of the thesis 9 Chapter 2 The changing epidemiology of Barrett s esophagus in the Netherlands Chapter 3 Environmental risk factors in the development of adenocarcinoma of the esophagus or gastric cardia: a cross-sectional study in a Dutch cohort Chapter 4 Capsule endoscopy for the detection of esophageal mucosal disorders: a comparison of two different ingestion protocols Chapter 5 Risk of esophageal adenocarcinoma and related mortality in patients with Barrett s esophagus: a systematic review and meta-analysis Chapter 6 Risk of malignant progression in patients with Barrett s esophagus: a Dutch nationwide cohort study 21 37 51 67 87 Chapter 7 Risk factors for the development of esophageal adenocarcinoma in patients with Barrett s esophagus 105 Chapter 8 Colorectal cancer risk in patients with Barrett s esophagus: a Dutch population-based study Chapter 9 Proton-pump inhibitor therapy in gastroesophageal reflux disease decreases the esophageal immune response but does not reduce the formation of DNA adducts 123 137 Chapter 10 General discussion and conclusion 155 Chapter 11 Summary 169 Samenvatting 174 Contributing authors 179 Dankwoord 185 Curriculum vitae auctoris 191 Portfolio 195
Curriculum vitae auctoris 193 Curriculum vitae auctoris De auteur van dit proefschrift werd geboren op 28 februari 1983 te Oud-Beijerland. Na het behalen van zijn Gymnasium diploma aan de Rijksscholengemeenschap Hoeksche Waard te Oud-Beijerland in 2001, werd in datzelfde jaar gestart met de studie Geneeskunde aan de Erasmus Universiteit Rotterdam. Na het behalen van de propedeutische fase met judicium cum laude, werd in 2002 tevens gestart met de MSc. opleiding Clinical Epidemiology. In het kader van deze studie werd onder meer deelgenomen aan de Summer School van Harvard University te Boston. In juli 2005 behaalde hij het doctoraalexamen en rondde hij gelijktijdig de studie Clinical Epidemiology af. Aansluitend werkte hij tot en met december 2007 als promovendus op de afdeling Maag-, Darm- en Leverziekten van het Erasmus MC. Onder leiding van zijn promotoren Prof.dr. E.J. Kuipers en Prof.dr. P.D. Siersema startte hij hier zijn onderzoek naar de epidemiologische aspecten met betrekking tot patienten met Barrett s oesofagus. Op 7 januari 2008 is hij gestart met zijn co-schappen. Het arts-examen zal naar verwachting in december 2009 behaald worden.
Chapter 11E Portfolio
Portfolio 197 Portfolio Conferences: 2009 Risk of colorectal cancer in patients with Barrett s esophagus: a Dutch populationbased study. Digestive Disease Week, Chicago, USA. (Poster) Risk of malignant progression in patients with Barrett s esophagus: a Dutch nationwide cohort study. Dutch Society of Gastroenterology, Veldhoven, the Netherlands. (Oral) 2008 Trends in the epidemiology of Barrett s esophagus in the Netherlands 1991-2006. Digestive Disease Week, San Diego, USA. (Oral) Risk of malignant progression in patients with Barrett s esophagus: a long-term nationwide study in the Netherlands. Digestive Disease Week, San Diego, USA. (Poster of distinction) 2007 Esophageal capsule endoscopy in patients with gastro-esophageal reflux disease and Barrett s esophagus: improvement of diagnostic accuracy. Digestive Disease Week, Washington, USA. (Poster) Dutch Society of Gastroenterology, Veldhoven, the Netherlands. (Oral) Proton pump inhibitor therapy in patients with symptomatic gastro-esophageal reflux disease reduces the cellular immune response in the distal esophagus. Digestive Disease Week, Washington, USA. (Poster) UEGW, Paris, France. (Poster) Wireless 48-hr ph monitoring is not superior to 24-hr ph monitoring combined with upper endoscopy for the detection of gastro-esophageal reflux disease. Digestive Disease Week, Washington, USA. (Poster) UEGW, Paris, France. (Poster) Day-to-day variation in acid reflux patterns in patients with non-erosive reflux disease and erosive reflux disease: clinically relevant or trivial? Dutch Society of Gastroenterology, Veldhoven, the Netherlands. (Oral) 2006 Environmental risk factors for the development of esophagus-cardia adenocarcinoma: a cross-sectional study in a Dutch cohort.
Digestive Disease Week, Los Angeles, USA. (Poster) European Society of Esophagology, Leuven, Belgium. (Poster) De 48-uurs ph meting met BRAVO capsule. Dutch Society of Gastroenterology, Veldhoven, the Netherlands. (Oral) 2005 Risk factors in Barrett s esophagus for the development of adenocarcinoma. Digestive Disease Week, Chicago, USA. (Poster) Dutch Society of Gastroenterology, Veldhoven, the Netherlands. (Oral) Memberships: 2005 Member of the Dutch Society of Gastroenterology (NVGE) Peer reviewer activities: 2008 Digestive and Liver Disease American Journal of Clinical Nutrition 2007 Scandinavian Journal of Gastroenterology 2006 American Journal of Gastroenterology Chapter 11 198