TriComfort Technology voor een gezond, natuurlijk gevoel en comfort.

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1 Levensstijl en compliance gaan niet altijd samen Zuurstof. Comfort. Zekerheid Novartis De unieke kenmerken van AIR OPTIX NIGHT&DAY TriComfort Technology voor een gezond, natuurlijk gevoel en comfort. Vasthouden van het vocht in de lens Buitengewone zuurstoftransmissie Uitstekende bevochtigbaarheid en weerstand tegen deposits 2011 Novartis

2 Nog steeds de hoogste zuurstoftransmissie van alle zachte lenzen 1* Oxygen profiles (-3.00D sphere) 2 Hoe hoger de Dk/L van een lens, hoe beter ze zal voldoen aan de zuurstofnood van de cornea vooral van de perifere cornea 3 Value for Dk/t calculated and noted below each oxygen profile using the manufacturer published center thickness at -3.00D when available, others as published in Tyler s Quarterly 2008; 25(4). *Other factors may impact eye health. References: 1. Based on the ratio of lens oxygen transmissibilities; CIBA VISION data on file, 2009, Based on in vitro measurement of thickness profiles of unworn lenses; CIBA VISION data on file, 2008, Alvord L, Hall J, Keyes D, et al. Corneal oxygen distribution with contact lens wear. Cornea. 2007;26(6): *Trademarks are the property of their respective owners Novartis Superieure bevochtigbaarheid en weerstand tegen neerslag In vitro measurement of unworn lenses, median values represented, n=20, CIBA VISION data on file, January *Compared to ACUVUE* OASYS*, ACUVUE* ADVANCE*, PureVision* and Biofinity* contact lenses. Reference: 1. In vitro measurement of unworn lenses; median values represented, n=20, CIBA VISION data on file, January *Trademarks are the property of their respective owners Novartis

3 Materiaal houdt vocht vast in de lens 2011 Novartis Uitstekend asferisch lens design AIR OPTIX NIGHT & DAY contactlenzen hebben een geavanceerd asferisch design om lenscomfort, passing en visus te optimaliseren De asferische binnenzijde is speciaal ontworpen om comfort en passing te bevorderen De asferische frontzijde werd ontworpen om de sferische aberratie te controleren, voor een meer heldere visus 2011 Novartis

4 Bijna de helft van de contactlensdragers slaapt of dut minimaal 1 keer per maand met de lenzen op het oog 1** In a typical month, how often do you sleep or accidentally fall asleep or nap in your soft contact lenses 1** Base (100%): More than once per month Less than once per month **Europe = weighted base size and results. Reference: 1. EUR Contact Lens Wearers U & A study, Novartis De ctl specialisten denken dat amper 16% van hun lensdragers slaapt met hun lenzen in 1 Even though you may not recommend it, about what percentage of all your soft contact lens customers do you believe currently sleep overnight in their soft contact lenses at least occasionally? 1 Nordics 28% 16% 14% 17% 11% 10% Base (All ECPs): Occasionally sleep overnight in soft contact lenses Reference: 1. ECP U & A CIBA VISION, July Novartis

5 Geen 2 cornea s reageren hetzelfde Corneazwelling gedurende de nacht varieert van drager tot drager, zelfs indien ze dezelfde contactlens dragen 1,2 Corneazwelling door s nachts doordragen van de lens kan moeilijk vast te stellen zijn bij het aanmeten van lens Indien u geen idee hebt hoe een cornea op een lens zal reageren, is het zinvol de lens met de hoogste zuurstoftransmissie te kiezen 3 References: 1. Moezzi A, Fonn D, Varikooty J, Richter D. Distribution of overnight central corneal swelling with high powered silicone hydrogel lenses. Optom Vis Sci. 2009;86: E-abstract In a randomized clinical study with 29 subjects; CIBA VISION data on file, Based on the ratio of lens oxygen transmissibilities; CIBA VISION data on file, 2009, Novartis AIR OPTIX NIGHT & DAY contactlenzen bieden de hoogste zuurstoftransmissie om oedeemvorming te minimaliseren Overnight corneal swelling 12 1,2 Average central corneal swelling response to overnight wear of D, -3.00D and +6.00D lenses at four levels of Dk/t. References: 1. Moezzi A, Fonn D, Varikooty J, Richter D. Distribution of Overnight Corneal Swelling Across Subjects with 4 Different Silicone Hydrogel Lenses. Eye & Contact Lens. 2011; 37(2): In a randomized clinical study with 29 subjects; CIBA VISION data on file, Novartis

6 INTRODUCTIE van AIR OPTIX NIGHT & DAY AQUA contactlenzen Een uitstekende lens voor dragers die (willen) slapen met hun lenzen in Zuurstof. Comfort. Zekerheid Novartis Nu met AQUA moisture component voor verbeterd comfort bij het aanbrengen 1 * Een unieke bevochtigingscomponent hecht zich aan het lensoppervlak en vormt een zijdezachte film. Het ooglid glijdt makkelijker over de lens en comfort bij het aanbrengen neemt toe 1* 2 *Preferred insertion comfort, versus original AIR OPTIX NIGHT & DAY lenses. Reference: 1. In a subject-masked clinical study at 13 sites with 114 subjects; significance demonstrated at the 0.05 level, CIBA VISION data on file, In a subject-masked clinical study at 13 sites with 114 wearers; CIBA VISION data on file, Novartis

7 Makkelijk hanteren en aanbrengen Een handling tint zorgt voor makkelijker hanteren / aanbrengen van de lens 1 * handling tint Originele AIR OPTIX NIGHT & DAY contactlenzen AIR OPTIX NIGHT & DAY AQUA contactlenzen *Versus original AIR OPTIX NIGHT & DAY contact lenses. Reference: 1. In a subject-masked clinical study at 13 sites with 114 subjects; significance demonstrated at the 0.05 level; CIBA VISION data on file, Novartis Verbeterde verpakking Omschakeling naar de globale AIR OPTIX blister, voor meer harmonisatie en makkelijker opslaan van voorraden en passets Omschakeling naar het gebruiksvriendelijke, i handige AIR OPTIX omdoosje Zijkant 2011 Novartis

8 Productkenmerken 2011 Novartis Zuurstof. Comfort. Zekerheid. **AIR OPTIX NIGHT & DAY AQUA (lotrafilcon A) contact lenses: Dk/t = -3.00D. Other factors may impact eye health. Important information for AIR OPTIX NIGHT & DAY AQUA (lotrafilcon A) contact lenses: AIR OPTIX NIGHT & DAY AQUA contact lenses are indicated for vision correction for daily wear (worn only while awake) or extended wear (worn while awake and asleep) for up to 30 nights. Relevant Warnings: A corneal ulcer may develop rapidly and cause eye pain, redness or blurry vision as it progresses. If left untreated, a scar, and in rare cases loss of vision, may result. The risk of serious problems is greater for extended wear vs. daily wear and smoking increases this risk. A one-year postmarket study found 0.18% (18 out of 10,000) of wearers developed a severe corneal infection, with 0.04% (4 out of 10,000) of wearers experiencing a permanent reduction in vision by two or more rows of letters on an eye chart. Relevant Precautions: Not everyone can wear for 30 nights. Approximately 80% of wearers can wear the lenses for extended wear. About two-thirds of wearers achieve the full 30 *CIBA VISION is the nights continuous wear. Side Effects: In clinical trials, approximately 3-5% of wearers experience at least one episode of infiltrative keratitis, a localized inflammation of the cornea which may be Vision Care Unit of ALCON accompanied by mild to severe pain and may require the use of antibiotic eye drops for up to one week. Other less serious side effects were conjunctivitis, lid irritation or lens discomfort including dryness, mild burning or stinging. Contraindications: Contact lenses should not be worn if you have: eye infection or inflammation (redness and/or swelling); eye disease, injury or dryness that interferes with contact lens wear; systemic disease that may be affected by or impact lens wear; certain allergic conditions or using certain medications (ex. some eye medications). Additional Information: Lenses should be replaced every month. If removed before then, lenses should be cleaned and disinfected before wearing again. Always follow the eye care professional s recommended lens wear, care and replacement schedule. Consult package insert for complete information, available without charge from CIBA VISION or visit mycibavision.com Novartis