UvA-DARE (Digital Academic Repository) Diagnosis, treatment and long-term effects of venous thromboembolism Cheung, Whitney Link to publication Citation for published version (APA): Cheung, Y. W. (2016). Diagnosis, treatment and long-term effects of venous thromboembolism General rights It is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulations If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: http://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. UvA-DARE is a service provided by the library of the University of Amsterdam (http://dare.uva.nl) Download date: 21 Oct 2017
DIAGNOSIS, TREATMENT AND LONG-TERM EFFECTS OF VENOUS THROMBOEMBOLISM YUK WAH CHEUNG
Diagnosis, treatment and long-term effects of venous thromboembolism Yuk Wah Cheung
ISBN: Author Cover design Lay-out Print 978-94-028-0376-1 Yuk Wah Cheung Jenny Kan www.jennykan.com Lyanne Tonk, persoonlijk proefschrift Ipskamp Printing Copyright 2016, Yuk Wah Cheung, Amsterdam, the Netherlands Printing of this thesis was financially supported by: Academisch Medisch Centrum/Universiteit van Amsterdam, Aspen Netherlands bv, Bayer bv, Chipsoft, CSL Behring bv, Federatie van Nederlandse Trombosediensten, Flevoziekenhuis, Medi Nederland bv, Pfizer bv, LEO Pharma bv, Sanofi-Aventis Nederland bv, Sanquin Plasma Products bv, Stichting tot Steun Promovendi Vasculaire Geneeskunde. Financial support by the Dutch Heart Foundation for the publication of this thesis is gratefully acknowledged.
Diagnosis, treatment and long-term effects of venous thromboembolism ACADEMISCH PROEFSCHRIFT ter verkrijging van de graad van doctor aan de Universiteit van Amsterdam op gezag van de Rector Magnificus prof. dr. ir. K.I.J. Maex ten overstaan van een door het College voor Promoties ingestelde commissie, in het openbaar te verdedigen in de Agnietenkapel op vrijdag 4 november 2016, te 14:00 uur door Yuk Wah Cheung geboren te Amsterdam
Promotiecommissie Promotor: Prof. dr. S. Middeldorp Universiteit van Amsterdam Copromotores: Dr. M. ten Wolde Flevoziekenhuis, Almere Dr. M. Coppens Universiteit van Amsterdam Overige leden: Prof. dr. H.R. Büller Universiteit van Amsterdam Prof. dr. M.A. Boermeester Universiteit van Amsterdam Prof. dr. M.M. Levi Universiteit van Amsterdam Prof. dr. M.V. Huisman Universiteit Leiden Prof. dr. P. Prandoni University of Padua Dr. A.J. ten Cate Universiteit Maastricht Faculteit der Geneeskunde
Table of contents Chapter 1. General introduction 9 Part I: Chapter 2. Chapter 3. Diagnostic management of pulmonary embolism Age-adjusted D-dimer cut-off levels to rule out pulmonary embolism Simplified diagnostic management of suspected pulmonary embolism 19 21 39 Part II: Chapter 4. Chapter 5. Chapter 6. Chapter 7. VTE treatment in special patient groups Direct oral anticoagulants in elderly patients Management and short-term prognosis of recurrent venous thromboembolism in anticoagulated patients Recurrent venous thromboembolism in anticoagulated patients with cancer: management and short-term prognosis Pharmacokinetics and dynamics of dabigatran etexilate and rivaroxaban in short bowel syndrome patients 55 57 75 91 111 Part III: Chapter 8. Chapter 9. Chapter 10. Treatment of DOAC-associated bleeding complications Management of bleeding complications in patients treated with direct oral anticoagulants: the present and future In-vivo increase in thrombin generation by four-factor prothrombin complex concentrate in apixaban-treated healthy volunteers In-vivo reversal of the anticoagulant effect of rivaroxaban with four-factor prothrombin complex concentrate 135 137 149 163
Part IV: Chapter 11. Chapter 12. Chapter 13. Chapter 14. Long-term effects of deep venous thrombosis: Post-thrombotic syndrome Post-thrombotic syndrome in patients treated with rivaroxaban or vitamin K antagonists for acute deep venous thrombosis: a post-hoc analysis Toll-like receptor 9 gene expression in the post-thrombotic syndrome, residual thrombosis and recurrent deep venous thrombosis: a case-control study Biomarkers for post-thrombotic syndrome: a case-control study Summary 177 179 193 207 255 Chapter 15. Nederlandse samenvatting 233 Addendum Co-authors and affiliations Portfolio Dankwoord Curriculum Vitae 243 245 251 255 263