Studies in cow s milk allergy: results from the Dutch EuroPrevall birth cohort Petrus, N.C.M.

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UvA-DARE (Digital Academic Repository) Studies in cow s milk allergy: results from the Dutch EuroPrevall birth cohort Petrus, N.C.M. Link to publication Citation for published version (APA): Petrus, N. C. M. (2016). Studies in cow s milk allergy: results from the Dutch EuroPrevall birth cohort General rights It is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulations If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: http://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. UvA-DARE is a service provided by the library of the University of Amsterdam (http://dare.uva.nl) Download date: 20 Sep 2017

Studies in cow s milk allergy: results from the Dutch EuroPrevall birth cohort Nicole C.M. Petrus Studies in cow s milk allergy: results from the Dutch EuroPrevall birth cohort Nicole C.M. Petrus

Studies in cow's milk allergy: results from the Dutch EuroPrevall birth cohort Nicole C.M. Petrus

Colofon ISBN: 978-94-92332-07-3 Cover design and layout: Esther Ris Printed By: Ipskamp Drukkers All rights are reserved. No part of this thesis may be reproduced or transmitted in any form or by any means, without permission of the authors and the publishers of the included scientific papers. The research in this thesis was financially supported by Stichting Steun Emma, European Commission (FOOD-CT_2005-514000), Nutricia Nederland, Nutricia Advanced Medical Nutrition, AstraZeneca, TEVA, GlaxoSmithKline and Volusense. Printing of this thesis was financially supported by Emma Kinderziekenhuis AMC, ALK Albello B.V., Chiesi Pharmaceuticals B.V., Fagron NL BV, Mead Johnson Nutrition, Meda Pharma B.V., Nutricia Advanced Medical Nutrition, Nutricia Early life Nutrition, Nutricia Research, Nestle Health Science.

Studies in cow s milk allergy: results from the Dutch EuroPrevall birth cohort ACADEMISCH PROEFSCHRIFT ter verkrijging van de graad van doctor aan de Universiteit van Amsterdam op gezag van de Rector Magnificus prof. dr. D.C. van den Boom ten overstaan van een door het College voor Promoties ingestelde commissie, in het openbaar te verdedigen in de Agnietenkapel op vrijdag 18 maart 2016, te 10.00 uur door Nicole Catharina Maria Petrus geboren te Castricum

Promotiecommissie Promotor: Prof. dr. W.M.C. van Aalderen Universiteit van Amsterdam Copromotor: Dr. A.B. Sprikkelman Universiteit van Amsterdam Overige leden: Prof. dr. M.A. Benninga Prof. dr. J. Garssen Prof. dr. R. Gerth van Wijk Prof. dr. J.B. van Goudoever Prof. dr. G.H. Koppelman Prof. dr. R. van Ree Universiteit van Amsterdam Universiteit Utrecht Erasmus Universiteit Rotterdam Universiteit van Amsterdam Rijksuniversiteit Groningen Universiteit van Amsterdam Faculteit der Geneeskunde

voor papa

Contents Chapter 1 Chapter 2 Chapter 3 Chapter 4 Chapter 5 Chapter 6 Chapter 7 Chapter 8 Chapter 9 General introduction and outline EuroPrevall birth cohort study: general description and major results Remaining symptoms in half the children treated for milk allergy Response to: cost-effectiveness of using an extensively hydrolysed formula compared to an amino acid formula as first-line treatment for cow milk allergy in the UK Exclusively breastfed infants at risk for false negative double blind placebo controlled milk challenge Cow s milk allergy in Dutch children: an epigenetic survey Genetic susceptibility for cow s milk allergy in Dutch children: the start of the allergic march? Early associations with asthma in young children with cow s milk allergy Comment on: prenatal exposure to acid suppressive drugs and the risk of allergic disease in the offspring: a cohort study 9 19 33 47 53 61 105 123 131 Chapter 10 Accuracy of tidal breathing measurement of FloRight compared to an ultrasonic flowmeter in infants Chapter 11 Summary and general discussion Chapter 12 Contributing Authors List of Publications Author Contributions Nederlandse samenvatting voor niet medici PhD portfolio Curriculum Vitae Dankwoord 137 157 171 176 178 181 185 188 189