UvA-DARE (Digital Academic Repository) Optimizing endoscopic therapy for early Barrett s neoplasia Künzli, H.T. Link to publication Citation for published version (APA): Künzli, H. T. (2018). Optimizing endoscopic therapy for early Barrett s neoplasia General rights It is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulations If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: http://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. UvA-DARE is a service provided by the library of the University of Amsterdam (http://dare.uva.nl) Download date: 08 Dec 2018
OPTIMIZING ENDOSCOPIC THERAPY FOR EARLY BARRETT S NEOPLASIA Hannah Tessi Künzli
Cover layout and design by Anne van Brakel, studio Cocorico. Printed by Off Page, Amsterdam, www.offpage.nl ISBN 978-94-6182-814-9 Copyright Hannah Tessi Künzli. All rights reserved. No parts of this thesis may be reproduced, stored or transmitted in any form or by any means without the prior permission of the author or publishers of the included scientific papers. The printing of this thesis was financially supported by Academisch Medisch Centrum Amsterdam, St. Antonius Ziekenhuis Nieuwegein, Nederlandse Vereniging voor Gastroenterologie, Nederlandse Vereniging voor Endoscopische Chirurgie, C2 Therapeutics, Chipsoft, Yakult Nederland B.V., Zambon Nederland B.V., Erbe Nederland B.V., Tramedico B.V., Ferring, Norgine, US Endoscopy
OPTIMIZING ENDOSCOPIC THERAPY FOR EARLY BARRETT S NEOPLASIA ACADEMISCH PROEFSCHRIFT ter verkrijging van de graad van doctor aan de Universiteit van Amsterdam op gezag van de Rector Magnificus prof. dr. ir. K.I.J. Maex ten overstaan van een door het College voor Promoties ingestelde commissie, in het openbaar te verdedigen in de Agnietenkapel op vrijdag 26 januari 2018, te 10.00 uur door Hannah Tessi Künzli geboren te Groningen
PROMOTIECOMMISSIE Promotor(es): Prof. dr. B.L.A.M. Weusten AMC-UvA Prof. dr. J.J.G.H.M. Bergman AMC-UvA Copromotor: Prof. dr. M.I. van Berge Henegouwen AMC-UvA Overige leden: Prof. dr. P. Fockens AMC-UvA Prof. dr. M.J. van de Vijver AMC-UvA Prof. dr. J.G.P. Tijssen AMC-UvA Dr. J.P. Ruurda UMC Utrecht Prof. Dr. F.P. Vleggaar Universiteit Utrecht Dr. E.J. Schoon Catharina Ziekenhuis Eindhoven Faculteit der Geneeskunde
Table of CONTENTS Chapter 1 General introduction and outline of this thesis 9 Part 1 Chapter 2 TAILORED TREATMENT OF SUBMUCOSAL ESOPHAGEAL ADENOCARCINOMA Surgical and endoscopic management after endoscopic resection of T1b esophageal adenocarcinoma: a retrospective cohort study of patients treated between 2001 and 2011 21 Surg Endosc. 2016 Sep;30:4102-13. Chapter 3 Endoscopic management and follow-up of patients with a submucosal esophageal adenocarcinoma treated between 2012 and 2016 43 Accepted for publication in United European Gastroenterology J. Chapter 4 Thoracolaparoscopic dissection of esophageal lymph nodes without esophagectomy is feasible in human cadavers and safe in a porcine survival study 61 Dis Esophagus. 2016 Aug;29:649-55. Chapter 5 Pilot-study on the feasibility of sentinel node navigation surgery in combination with thoracolaparoscopic lymphadenectomy without esophagectomy in early esophageal adenocarcinoma patients 77 Dis Esophagus 2017: 30: 1-8 Part 2 Chapter 6 REFINING ABLATION THERAPY OF BARRETT S EPITHELIUM Simplified protocol (3x15J/cm 2 - no clean) for focal radiofrequency ablation using the HALO 90 device: short-term efficacy and safety in patients with dysplastic Barrett s esophagus 97 Endoscopy. 2015 Jul;47:592-7 Chapter 7 A multicenter randomized controlled trial comparing a simplified (3x12J/cm 2 -no clean) and standard regimen for focal radiofrequency ablation of dysplastic Barrett s esophagus 113 Submitted Chapter 8 Treatment of Barrett s esophagus with a novel focal cryoablation device: initial results of a dosimetry study 133 Endoscopy. 2015 Dec; 47: 1106-12 Chapter 9 Efficacy of the CryoBalloon Focal Ablation System for the eradication of dysplastic Barrett s esophagus islands 149 Endoscopy. 2017 Feb;49:169-175.
Chapter 10 General discussion 161 Addendum Summary 177 Nederlandse samenvatting 183 List of publications 188 Contributing authors 190 PhD portfolio 193 About the author 195 Dankwoord 196
Voor mam & pap