Citation for published version (APA): Bolhuis, M. (2015). Linezolid in multidrug-resistant tuberculosis [S.l.]: [S.n.]

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1 University of Groningen Linezolid in multidrug-resistant tuberculosis Bolhuis, Mathieu IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below. Document Version Publisher's PDF, also known as Version of record Publication date: 2015 Link to publication in University of Groningen/UMCG research database Citation for published version (APA): Bolhuis, M. (2015). Linezolid in multidrug-resistant tuberculosis [S.l.]: [S.n.] Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons). Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Downloaded from the University of Groningen/UMCG research database (Pure): For technical reasons the number of authors shown on this cover page is limited to 10 maximum. Download date:

2 Linezolid in multidrug-resistant tuberculosis Mathieu S. Bolhuis

3 Publication of this thesis was supported by the KNCV Tuberculosis Foundation, Stichting ter bevordering van Onderzoek in de Ziekenhuisfarmacie te Groningen (Stichting O.Z.G.), Stichting Beatrixoord Noord Nederland, Groningen University Institute for Drug Exploration (GUIDE), Stichting KNMP-fondsen, and UMCG Center for Rehabilitation Beatrixoord. Cover Mathieu Bolhuis Cover image Pax Nicholas & the Nettey family, Daptone Recording Co. Layout Renate Siebes, Proefschrift.nu Printed by Drukkerij Van Gorcum, Assen ISBN Mathieu S. Bolhuis, 2015 Copyright of the published articles is with the corresponding journal or otherwise with the author. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, without the prior permission in writing from the author or the copyright-owning journal.

4 Linezolid in multidrug-resistant tuberculosis Proefschrift ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen op gezag van de rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties. De openbare verdediging zal plaatsvinden op woensdag 18 februari 2015 om uur door Mathieu Sander Bolhuis geboren op 11 mei 1981 te Groningen

5 Promotores Prof. dr. T.S. van der Werf Prof. dr. J.G.W. Kosterink Prof. dr. D.R.A. Uges Copromotor Dr. J.W.C. Alffenaar Beoordelingscommissie Prof. dr. D.M. Burger Prof. dr. F.G.J. Cobelens Prof. dr. G.M.M. Groothuis

6 Contents Chapter 1 General introduction 7 Chapter 2 Pharmacokinetic drug interactions of antimicrobial drugs: a systematic review on oxazolidinones 17 Chapter 3A Clarithromycin significantly increases linezolid serum concentrations 27 Chapter 3B Chapter 4A Chapter 4B Chapter 5A Clarithromycin increases linezolid exposure in multidrug-resistant tuberculosis patients Dried blood spot analysis for therapeutic drug monitoring of linezolid in MDR-TB patients Clinical validation of the analysis of linezolid and clarithromycin in oral fluid of multidrug-resistant tuberculosis patients Comment on: Daily 300 mg dose of linezolid for multidrug-resistant and extensively drug-resistant tuberculosis: updated analysis of 51 patients Chapter 5B Linezolid: safety and efficacy monitoring 81 Chapter 5C Chapter 6 Linezolid safety and tolerability in multidrug-resistant tuberculosis patients: a retrospective observational study In vitro synergy between linezolid and clarithromycin against Mycobacterium tuberculosis Chapter 7 General discussion and future perspectives 111 Summary 123 Samenvatting 131 Co-authors of manuscripts presented in this thesis 145 Dankwoord 149 About the author 157

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