Citation for published version (APA): Ruizendaal, E. (2017). Malaria in pregnancy: In search of tools for improved prevention

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1 UvA-DARE (Digital Academic Repository) Malaria in pregnancy Ruizendaal, E. Link to publication Citation for published version (APA): Ruizendaal, E. (2017). Malaria in pregnancy: In search of tools for improved prevention General rights It is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulations If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. UvA-DARE is a service provided by the library of the University of Amsterdam ( Download date: 22 Oct 2017

2 Malaria in pregnancy: in search of tools for improved prevention Esmée Ruizendaal Malaria in pregnancy: in search of tools for improved prevention Esmée Ruizendaal

3 Malaria in pregnancy: in search of tools for improved prevention Esmée Ruizendaal

4 Colofon MALARIA IN PREGNANCY: IN SEARCH OF TOOLS FOR IMPROVED PREVENTION ISBN/EAN: Copyright 2017 E. Ruizendaal All rights reserved. No part of this thesis may be reproduced, stored or transmitted in any way or by any means without the prior permission of the author, or when applicable, of the publishers of the scientific papers. Cover design by E. Ruizendaal Layout and design by Jules Verkade, persoonlijkproefschrift.nl. Printed by Ipskamp Printing, proefschriften.net.

5 MALARIA IN PREGNANCY: IN SEARCH OF TOOLS FOR IMPROVED PREVENTION ACADEMISCH PROEFSCHRIFT ter verkrijging van de graad van doctor aan de Universiteit van Amsterdam op gezag van de Rector Magnificus prof. dr. ir. K.I.J. Maex ten overstaan van een door het College voor Promoties ingestelde commissie, in het openbaar te verdedigen in de Agnietenkapel op vrijdag 20 oktober 2017, te uur door Esmée Ruizendaal geboren te IJsselstein

6 Promotiecommissie: Promotor: prof. dr. M.D. de Jong AMC-UvA Copromotor: dr. P.F. Mens AMC-UvA Overige leden: prof. dr. M. Boele van Hensbroek AMC-UvA prof. dr. F.G.J. Cobelens AMC-UvA prof. dr. M.P. Grobusch AMC-UvA prof. dr. T.F. Rinke de Wit AMC-UvA prof. dr. R.W. Sauerwein Radboud UMC, Nijmegen dr. E. van Leeuwen AMC-UvA Faculteit der Geneeskunde

7 Table of contents Chapter 1 General introduction and outline of the thesis 7 Part I Chapter 2 Success or failure of critical steps in community case management of malaria with rapid diagnostic tests: a systematic review 27 Chapter 3 Community-based scheduled screening and treatment of malaria in pregnancy for improved maternal and infant health in The Gambia, Burkina Faso and Benin: study protocol for a randomized controlled trial 73 Chapter 4 Evaluation of malaria screening during pregnancy with rapid diagnostic tests performed by community health workers in Burkina Faso, West Africa 91 Chapter 5 Increase in the prevalence of mutations associated with sulfadoxinepyrimethamine resistance in Plasmodium falciparum isolates collected from early to late pregnancy in Nanoro, Burkina Faso 125 Part II Chapter 6 Peripheral and placental biomarkers in women with placental malaria: a systematic review 163 Chapter 7 Interleukin-10 and soluble tumour necrosis factor receptor II are potential biomarkers of Plasmodium falciparum infections in pregnant women: a case-control study from Nanoro, Burkina Faso 235 Chapter 8 Variant surface antigen 2-chondroitin sulphate A (VAR2CSA) antibody levels and protection from Plasmodium falciparum infections in pregnant women from Nanoro, Burkina Faso 261 Chapter 9 Discussion 285 Chapter 10 Summary Samenvatting 305 Addendum Authors and affiliations PhD Portfolio List of Publications Dankwoord About the author 317

8 Een goed begin is het halve werk, maar een goed begin is maar de helft. De Jeugd van Tegenwoordig Sterrenstof 6