University of Groningen. Isolated limb infusion Kroon, Hidde Maarten

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1 University of Groningen Isolated limb infusion Kroon, Hidde Maarten IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below. Document Version Publisher's PDF, also known as Version of record Publication date: 2009 Link to publication in University of Groningen/UMCG research database Citation for published version (APA): Kroon, H. M. (2009). Isolated limb infusion s.n. Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons). Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Downloaded from the University of Groningen/UMCG research database (Pure): For technical reasons the number of authors shown on this cover page is limited to 10 maximum. Download date:

2 Dankwoord

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4 Dankwoord Iedereen die een bijdrage heeft geleverd aan het tot stand komen van mijn proefschrift ben ik dankbaar. Een aantal van hen wil ik graag met name noemen: Allereerst mijn promotor Professor dr. H.J. Hoekstra. Beste Harald, jij bent het mastermind achter mijn proefschrift. Op het moment dat ik jou benaderde voor mijn afstudeeronderzoek, dat ik graag in de Verenigde Staten wilde doen, had jij een lijst met mogelijke instituten waar ik heen zou kunnen. Chang s lab in Ann Arbor bleek een perfecte keus. Nog voordat ik met het onderzoek begon liet jij al de woorden proefschrift en promoveren vallen. Als co-assistent was ik daar nog helemaal niet mee bezig en klonk het heel ver weg. Met de door jou bedachte Michigan-Sydney-Groningen constructie was je mijn gedachten voor. Vooral je duidelijkheid en snelheid heb ik door de jaren heen zeer gewaardeerd. Hartelijk dank voor je nimmer aflatende steun tijdens mijn onderzoek aan verre instituten. Dankwoord My promotor Professor J.F. Thompson. Dear Prof, thank you for trusting me in analyzing the isolated limb infusion data, a technique invented and further developed by you. It has been a great learning experience to work on this project which gave me the chance to do the number of analyses that I managed to do. Working under your supervision in the Sydney Melanoma Unit has made me independent in my approach of research and my thinking. It has been a great experience to work with the melanomologist. My promotor Professor A.E. Chang. Dear Fred, you offered me a research project in your laboratory. In the light of my lack of previous laboratory research experience I think this is extraordinary. I have learned more than I can describe in the meetings, from the colleagues in your laboratory and from you. You are a perfect mentor: modest, open for discussion, easily approachable and always engaged in improving the research projects. I feel honored that you gave me the opportunity to work in your famous laboratory. Leden van de beoordelingscommissie, Prof. dr. A.M.M. Eggermont, Prof. dr. J.Th.M. Plukker, Prof. dr. Th. Wobbes, dank voor uw bereidheid mijn proefschrift op zijn wetenschappelijke waarde te beoordelen. Dr. M.S. Sabel. Dear Michael, your enthusiasm in undertaking research is contagious. You are always full of new interesting ideas. I hope to meet you again at future meetings as one of the moderators in the melanoma sessions and during the breaks of course. 233

5 Dr. Q. Li. Dear Qiao, it has been a great experience to do my laboratory work with you only two doors down the hall. The fact that I could ask for your help and thoughts at any moment of the day has been very helpful for me to increase my understanding of immunotherapy. Thank you for an enjoyable year at the University of Michigan. Professor P.C.A. Kam. Dear Prof. Kam, as one of the founding fathers of the isolated limb infusion technique I owe you many thanks. It has been a pleasure to see you working as anesthesiologist and being able to ask you anything. I admire your calm and cheerful character even at stressful times in the operating theatre. Thank you for your help in preparing the manuscripts that are included in this thesis. J.R. Whitfield. Dear Joel, you prove that a healthy working climate increases productivity. I will never forget our countless discussions on politics, world leaders, wars, cultures, sports, etcetera, while learning the real time polymerase chain reaction procedure from you. Working in your laboratory never felt like actual work but more like having a friendly discussion with lots of laughter. Thank you for all the enjoyable hours of work! Dr. S. Teitz-Tennenbaum. Dear Seagal, thank you for teaching me the laboratory procedures and helping me preparing the manuscript included in this thesis. It has been great to work with you and I am sure we will meet again at one of the international congresses. Dr. M.D. Moncrieff. Dear Marc, thank you for your help in the statistical analyses. Our research discussions during the sailing trips from Sydney Harbour to Pitt Water have definitely highlighted my SMU experience, with the dolphins swimming along Searenity as the ultimate experience. I hope we can get involved in more sailing trips now we re both in Europe and living nearby. Dr. D.Y. Lin. Dear Indy, thank you for your help in analyzing the data and preparing the manuscripts. It has been great to present and publish our first papers together and I am sure there are more to come in the future, maybe even in Dutch.. Dr. Chang s laboratory. Dear Riuji, Elizabeth and Take, thank you for the enjoyable atmosphere in the laboratory. As an inexperienced basic researcher I felt at home quickly and would have never finished the paper without your help. 234

6 Kaye Oakley. Dear Kaye, Prof. Thompson would probably be lost without your excellent support. Thank you very much for all your help, tact and patience in stressful times. The Sydney Melanoma Unit-database. Dear Kim, Maria, Ashna, Tess and Marjorie, I could write a thousand words and it still wouldn t be enough! Thank you all for all your help and for being the listening ear when I just spilled out my thoughts to you, sometimes regarding my research, many times regarding Australia, news, people, etcetera etcetera. I miss all the fun talks and the stomach aches from laughing! It is true what you wrote when I left: We zullen geen afscheid, maar zie je later! Spot on! Dankwoord All the physicians, nurses, clinical trial specialists and other personnel of the Sydney Melanoma Unit, thank you for making me part of the largest melanoma unit in the world. It has been quite an experience to work in a clinic that develops new melanoma treatments based on its own experience. The SMU is truly something special. Dr. A.B. Francken. Beste Anne Brecht, ik had mij geen betere voorganger kunnen wensen. Dank voor al je hulp, tips, adviezen en het delen van jouw ervaringen in Sydney. All the guys from Nu Sigma Nu Medical Fraternity in Ann Arbor. Going abroad for a substantial time can be tough. Fortunately I moved into a house with 30 guys which made it a piece of cake. Thanks for all the good times in and outside of the house! We ve already caught up both in the USA and in the Netherlands and I am looking forward to do this in the future many more times as colleagues and as friends! Caitlyn Milazzo. Dear Cait, though our research topics could not be further apart, we connected instantly. I always enjoy hearing your thoughts and stories. Thank you for your visits and I hope we will meet again soon; in sunny California this time? Crew from Cyrene 3 and Shiralee, I will never forget the countless hours on the Sydney Harbour! It didn t take me long to realize this is probably the best sailing in the world! Thank you for the team efforts during the races and the socializing after. I hope you realize this dissertation will not be of any help during an emergency situation at open waters! Special thanks to Rob, Sue, Mike and Elena for having me as crew on your beautiful yachts. I hope to see you at the start of the Sydney Hobart race soon! 235

7 Bastiaan van der Reijt. Beste Bas, na elkaar vier jaar eerder één keer s nachts in Amsterdam gesproken te hebben was het als een thuiskomst toen ik bij jou in Sydney kwam. Dankzij jou heb ik niet alleen heel gezellig maar ook nog eens op de mooiste plekjes van Sydney kunnen wonen! Met veel bewondering heb ik jouw en je broers initiatieven op de beurs van Sydney van de zijlijn gevolgd. Dank je voor je interesse in mijn onderzoek! Pépé Grégoire. Beste Pépé, jouw beelden spreken voor zichzelf en ik ben blij dat ik Windkracht 14 mag gebruiken als passende foto voor de omslag van mijn proefschrift. Je gastvrijheid en de passie waarmee je over je nieuwe ideeën voor kunstwerken spreekt hebben veel indruk op mij gemaakt. Ik hoop snel een keer een polowedstrijd bij te kunnen wonen. Club, huis, Forwardianen en vrienden, dank voor de leuke belletjes en mailtjes! Vooral de bezoeken die ik heb gehad in de V.S. en in Australië heb ik als heel bijzonder ervaren. Een stimulans voor het onderzoek. Mijn zus en broer. Lieve Annie, ook al was ik vaak ver weg, de mails en kaartjes bleven komen. Dank voor je interesse en steun. Lieve Bin, ik vond het heel bijzonder bij jouw promotie paranimf te zijn en ben blij dat tijdens mijn promotie deze jongste familietraditie kan worden voortgezet met dit keer Marije aan mijn zijde. Mijn paranimfen Dr. R.G. van Lingen en Drs. M.W. Kroon. Lieve Roos, mijn studiemaatje. Jij bent mij net altijd iets voor. Je wist een paar uur eerder dan ik dat ook jij (eindelijk) was ingeloot. Je studeerde een paar maanden eerder af, je was eerder in opleiding en nu ook weer vier maanden eerder gepromoveerd. Ik hoop dat je dit goede voorbeeld blijft geven. Ik vond het een eer om bij jou paranimf te mogen zijn en ik ben blij dat ook ik vandaag jou aan mijn zijde mag hebben. Lieve Marije, zus en ook arts. In een dermatologisch promotietraject zet ook jij de familietraditie voort. Waar ik ook zat, jij kwam mij, samen met Heit en Mem, opzoeken voor een vakantie die ik maar wat graag met jullie mee vierde. Dank je dat jij mijn paranimf wil zijn. Mijn ouders, lieve Heit en Mem, dank voor jullie nimmer aflatende steun en vertrouwen in werkelijk alles. Zonder jullie als vaste rots in de branding hadden deze onderzoeksperioden nooit dit resultaat gehad. Lieve Heit, speciaal jou wil ik ook danken voor je wetenschappelijke ondersteuning. Jouw inzet en steun zijn van het niveau geweest als van een promotor. 236

8 Lieve Indy, je hebt alles in Sydney achtergelaten om ons leven samen in Nederland voort te kunnen zetten. Hoe kan ik je hier ooit voor bedanken? Ik kijk uit naar ons nieuwe leven hier en hoop dat je je het Nederlands snel eigen maakt zodat je deze woorden al heel binnenkort kunt begrijpen. Dankwoord 237

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