Cover Page. The handle holds various files of this Leiden University dissertation.

Maat: px
Weergave met pagina beginnen:

Download "Cover Page. The handle holds various files of this Leiden University dissertation."

Transcriptie

1 Cover Page The handle holds various files of this Leiden University dissertation. Author: Hannula, Emilia Title: Assessment of the effects of genetically modified potatoes on structure and functioning of soil fungal communities Date:

2 179

3 Transgene technieken zijn tegenwoordig een acceptabele manier om gewassen te verbeteren. Ondanks de toenemende hoeveelheid landbouwgrond die gebruikt wordt voor het verbouwen van genetisch gemodificeerde (GG) gewassen, zijn de effecten hiervan op de schimmelgemeenschap in de bodem grotendeels onbekend. Het doel van dit proefschrift was daarom om de effecten van GG aardappelen, die een andere zetmeelsamenstelling hebben, op de schimmel gemeenschap in de bodem te bepalen door te kijken naar veranderingen in wortel afscheiding en weefselsamenstelling in de planten. Daarbij zijn vergelijkingen gemaakt tussen de GG- (genaamd Modena ) en de moederplant (genaamd Karnico ), in ogenschouw nemend dat natuurlijke variaties (jaar, klimaat, veldlocatie, groei stadium van de plant, verschillende aardappel soorten) al optreden bij gebruik van niet GG aardappelen. Allereerst zijn de methodes ontwikkeld die nodig zijn om deze evaluaties uit te voeren. Vervolgens zijn deze methodes gebruikt op 2 veldlocaties in een 3-jarig experiment om de natuurlijke variatie die verschillende aardappelsoorten hebben op de bodemschimmels te bepalen en in 2 kasexperimenten om de effecten op wortel uitscheiding en plantweefsel compositie te bestuderen. Hoofdstuk 3 beschrijft de ontwikkeling van de methodes die het mogelijk maakten om de effecten van de GG-gewassen op de bodemschimmel samenstelling en functionaliteit te bestuderen die in de rest van het proefschrift gebruikt zijn. Om aan te tonen dat de methodes goed functioneren is in eerste instantie in een 1-jaars veld experiment gekeken naar de dynamiek van schimmels in velden waarop GGaardappelen, de originele aardappelsoort en vier andere aardappelsoorten groeiden. Hieruit bleek onder andere dat de schimmelgemeenschapsamenstelling -en functionaliteit nagenoeg identiek was voor de GG-aardappel in vergelijking met de originele aardappel variëteit. In hoofdstuk 4 is de normale variatie van landbouw gerelateerde activiteiten in het hierboven beschreven veldexperiment geëvalueerd. De groeifase van de plant bleek het grootste effect te hebben op de schimmel gemeenschap in de rhizosfeer. De grootste schimmelbiomassa werd gevonden in de fase waarin de aardappelen al verouderd waren, hoewel verschillende schimmelgroepen verschillende patronen in hun dominantie lieten zien. Ook werden er meer ascomyceten dan basidiomyceten en schimmels in het algemeen gezien in 2010 op beide proefvelden in vergelijking met Dit is een indicatie dat ook de veranderde bemestingsstrategie een invloed kan hebben op de schimmelgemeenschap. Ondanks het grote verschil in organisch materiaal in de grond van de twee proefvelden, bleek de veldlocatie verrassend genoeg geen invloed te hebben op de diversiteit en functionaliteit van de gemeenschap van hogere schimmels en de resultaten van de twee velden konden gecombineerd worden om de normale variatie te bepalen. Ondanks dat er verschillen werden gemeten in schimmel-gerelateerde parameters in de vergelijking van de verschillende aardappelsoorten, waren er geen direct gerelateerde effecten en waren de meeste verschillen niet consistent tussen de velden en de verschillende jaren. Verder werden er geen significante verschillen gemeten tussen de GG-soort Modena en de originele soort Karnico, waarmee bewezen is dat deze twee aardappelsoorten een zeer vergelijkbaar effect hebben op de schimmel gemeenschap 180

4 en functionaliteit. Het enige langere termijn verschil was het verschil in aantallen schimmels in de rhizosfeer in één veld in de verouderingsgroeifase van de aardappelen in 2008, 2009 en Dit fenomeen werd verder onderzocht in hoofdstuk 5. Het doel van hoofdstuk 5 was om inzicht te krijgen in de koolstof distributie van de wortels van GG- en de originele aardappel naar de schimmel gemeenschap in de grond wat onderzocht werd met stable isotope probing (SIP). Dit experiment werd uitgevoerd met grond verkregen van één van de velden beschreven in hoofdstuk 3 & 4 en de verouderde groeifase werd onderzocht om de geobserveerde verschillen in het veldexperiment te bevestigen. De micro-organismen die 13C van de plant ontvingen, werden bepaald met RNA/PLFA-SIP op 3 tijdstippen en de schimmelgemeenschappen Ascomycota, Basidiomycota en Glomeromycota werden gescheiden geanalyseerd. Ascomyceten en glomeromyceten ontvingen al koolstof van de plant respectievelijk 1 en 5 dagen na de labeling, terwijl basidiomyceten langzamer waren in het opnemen van gelabeld koolstof. De snelheid van koolstofafscheiding van de GG-aardappelen was anders dan van de originele variant waardoor de schimmel gemeenschap werd beïnvloed. Er kon ook geconcludeerd worden dat saprotropische en mycorrhizale schimmels snel organische substraten kunnen metaboliseren die van de wortel naar de rhizosfeer gaan. Verder waren er grote verschillen in het gebruik van componenten afkomstig van de wortel op een lager fylogenetisch niveau binnen de onderzochte fyla. De actieve gemeenschap in de rhizosfeer is verschillend voor GG-planten en de originele planten wat wordt veroorzaakt door de effecten van verschillende koolstof bewegingen vanaf de planten. Het effect van potentieel onbedoelde veranderingen in plant compositie, die mogelijk schimmels binnen het bodem voedselweb beïnvloeden, werd onderzocht in hoofdstuk 6. De aardappelplanten die voor hoofdstuk 5 in een kas waren gegroeid werden gebruikt en de bladeren en (poot)aardappelen werden in zakken gedaan met grond afkomstig van de veldlocaties. Het gewichtsverlies van zowel de composterende bladeren als pootaardappelen werd geanalyseerd na 1, 3 en 6 maanden incubatie in de bodemmonsters en de data werd gecombineerd met metingen van extracellulaire enzym-activiteiten van de schimmels (laccase, Mn-peroxidase en cellulase) en moleculaire analyse van de schimmel gemeenschap functionaliteit en fylogenetische diversiteit. Deze experimenten toonden aan dat de initiële decompositie van de bladeren en pootaardappelen sneller verliep met de originele aardappelsoort, wat ook leidde tot een andere schimmel gemeenschap samenstelling. Na dit initiële verschil werden geen verschillen meer gemeten na 3 en 6 maanden decompositie wat aangeeft dat het initiële verschil niet tot langdurige effecten leidt. Daarom kan geconcludeerd worden dat zetmeel-gemodificeerde aardappelen geen risico vormen voor de schimmel gedomineerdevoedselketen in de bodem en dat ondanks het initieel gemeten verschil de overall decompositie snelheid van de GGaardappelsoort vergelijkbaar is met die van de originele aardappelsoort. Deze bevinding werd bevestigd in de veldexperimenten. 181

5 182

Cover Page. The handle http://hdl.handle.net/1887/37037 holds various files of this Leiden University dissertation

Cover Page. The handle http://hdl.handle.net/1887/37037 holds various files of this Leiden University dissertation Cover Page The handle http://hdl.handle.net/1887/37037 holds various files of this Leiden University dissertation Author: Lupatini, Manoeli Title: Microbial communities in Pampa soils : impact of land-use

Nadere informatie

Cover Page. The handle holds various files of this Leiden University dissertation

Cover Page. The handle  holds various files of this Leiden University dissertation Cover Page The handle http://hdl.handle.net/1887/22286 holds various files of this Leiden University dissertation Author: Nezhinsky, A.E. Title: Pattern recognition in high-throughput zebrafish imaging

Nadere informatie

Cover Page. The handle http://hdl.handle.net/1887/37134 holds various files of this Leiden University dissertation.

Cover Page. The handle http://hdl.handle.net/1887/37134 holds various files of this Leiden University dissertation. Cover Page The handle http://hdl.handle.net/1887/37134 holds various files of this Leiden University dissertation. Author: Zhang, Yu Title: Functional analysis of Dof transcription factors controlling

Nadere informatie

Cover Page. The handle http://hdl.handle.net/1887/20358 holds various files of this Leiden University dissertation.

Cover Page. The handle http://hdl.handle.net/1887/20358 holds various files of this Leiden University dissertation. Cover Page The handle http://hdl.handle.net/1887/20358 holds various files of this Leiden University dissertation. Author: Witsenburg, Tijn Title: Hybrid similarities : a method to insert relational information

Nadere informatie

Cover Page. The handle http://hdl.handle.net/1887/29754 holds various files of this Leiden University dissertation

Cover Page. The handle http://hdl.handle.net/1887/29754 holds various files of this Leiden University dissertation Cover Page The handle http://hdl.handle.net/1887/29754 holds various files of this Leiden University dissertation Author: Cao, Lu Title: Biological model representation and analysis Issue Date: 2014-11-20

Nadere informatie

Cover Page. The handle http://hdl.handle.net/1887/35942 holds various files of this Leiden University dissertation

Cover Page. The handle http://hdl.handle.net/1887/35942 holds various files of this Leiden University dissertation Cover Page The handle http://hdl.handle.net/1887/35942 holds various files of this Leiden University dissertation Author: Ent, Wietske van der Title: In vivo modelling of Ewing sarcoma in zebrafish Issue

Nadere informatie

Cover Page. The handle http://hdl.handle.net/1887/21953 holds various files of this Leiden University dissertation.

Cover Page. The handle http://hdl.handle.net/1887/21953 holds various files of this Leiden University dissertation. Cover Page The handle http://hdl.handle.net/1887/21953 holds various files of this Leiden University dissertation. Author: Schalkwijk, Daniël Bernardus van Title: Computational modeling of lipoprotein

Nadere informatie

Cover Page. The handle holds various files of this Leiden University dissertation.

Cover Page. The handle  holds various files of this Leiden University dissertation. Cover Page The handle http://hdl.handle.net/1887/29716 holds various files of this Leiden University dissertation. Author: Schraagen, Marijn Paul Title: Aspects of record linkage Issue Date: 2014-11-11

Nadere informatie

Cover Page. The handle holds various files of this Leiden University dissertation.

Cover Page. The handle  holds various files of this Leiden University dissertation. Cover Page The handle http://hdl.handle.net/1887/20432 holds various files of this Leiden University dissertation. Author: Linden- van der Zwaag, Henrica Maria Jannetta van der Title: CAOS & TKA. A critical

Nadere informatie

Cover Page. The handle holds various files of this Leiden University dissertation

Cover Page. The handle  holds various files of this Leiden University dissertation Cover Page The handle http://hdl.handle.net/1887/24306 holds various files of this Leiden University dissertation Author: Verhagen, T.G.A. Title: Magnetism and magnetization dynamics in thin film ferromagnets

Nadere informatie

Cover Page. Author: Slieker, Roderick Title: Charting the dynamic methylome across the human lifespan Issue Date:

Cover Page. Author: Slieker, Roderick Title: Charting the dynamic methylome across the human lifespan Issue Date: Cover Page The handle http://hdl.handle.net/1887/45888 holds various files of this Leiden University dissertation Author: Slieker, Roderick Title: Charting the dynamic methylome across the human lifespan

Nadere informatie

Cover Page. The handle holds various files of this Leiden University dissertation

Cover Page. The handle  holds various files of this Leiden University dissertation Cover Page The handle http://hdl.handle.net/1887/40161 holds various files of this Leiden University dissertation Author: Ledezma Yanez, Isis Title: The role of water in hydrogen electrocatalysis Issue

Nadere informatie

Cover Page. The handle holds various files of this Leiden University dissertation.

Cover Page. The handle  holds various files of this Leiden University dissertation. Cover Page The handle http://hdl.handle.net/1887/31633 holds various files of this Leiden University dissertation. Author: Kant, Anne Marie van der Title: Neural correlates of vocal learning in songbirds

Nadere informatie

Cover Page. The handle http://hdl.handle.net/1887/32149 holds various files of this Leiden University dissertation.

Cover Page. The handle http://hdl.handle.net/1887/32149 holds various files of this Leiden University dissertation. Cover Page The handle http://hdl.handle.net/1887/32149 holds various files of this Leiden University dissertation. Author: Renema, Jelmer Jan Title: The physics of nanowire superconducting single-photon

Nadere informatie

Leven in een broccoli wereld: Ontwerp van een beslis matrix ter beoordeling van de impact van nieuwe (GM) gewassen op het bodemecosysteem

Leven in een broccoli wereld: Ontwerp van een beslis matrix ter beoordeling van de impact van nieuwe (GM) gewassen op het bodemecosysteem Samenvatting Leven in een broccoli wereld: Ontwerp van een beslis matrix ter beoordeling van de impact van nieuwe (GM) gewassen op het bodemecosysteem Landbouw is essentieel voor de voedselvoorziening

Nadere informatie

Cover Page. The handle holds various files of this Leiden University dissertation.

Cover Page. The handle  holds various files of this Leiden University dissertation. Cover Page The handle http://hdl.handle.net/1887/40905 holds various files of this Leiden University dissertation. Author: Ateba Ngoa, U. Title: The effect of parasitic co-infections on immune responses

Nadere informatie

Cover Page. The handle http://hdl.handle.net/1887/29570 holds various files of this Leiden University dissertation.

Cover Page. The handle http://hdl.handle.net/1887/29570 holds various files of this Leiden University dissertation. Cover Page The handle http://hdl.handle.net/1887/29570 holds various files of this Leiden University dissertation. Author: Beek, Maurice H. ter Title: Team automata : a formal approach to the modeling

Nadere informatie

Cover Page. The handle http://hdl.handle.net/1887/20925 holds various files of this Leiden University dissertation.

Cover Page. The handle http://hdl.handle.net/1887/20925 holds various files of this Leiden University dissertation. Cover Page The handle http://hdl.handle.net/1887/20925 holds various files of this Leiden University dissertation. Author: Tabak, F.C. Title: Towards high-speed scanning tunneling microscopy Issue Date:

Nadere informatie

Cover Page. The handle http://hdl.handle.net/1887/37172 holds various files of this Leiden University dissertation.

Cover Page. The handle http://hdl.handle.net/1887/37172 holds various files of this Leiden University dissertation. Cover Page The handle http://hdl.handle.net/1887/37172 holds various files of this Leiden University dissertation. Author: Kortlever, Ruud Title: Selective and efficient electrochemical CO2 reduction on

Nadere informatie

Cover Page. The handle http://hdl.handle.net/1887/22544 holds various files of this Leiden University dissertation

Cover Page. The handle http://hdl.handle.net/1887/22544 holds various files of this Leiden University dissertation Cover Page The handle http://hdl.handle.net/1887/22544 holds various files of this Leiden University dissertation Author: Speksnijder, Niels Title: Determinants of psychosis vulnerability : focus on MEF2

Nadere informatie

Cover Page. The handle holds various files of this Leiden University dissertation.

Cover Page. The handle  holds various files of this Leiden University dissertation. Cover Page The handle http://hdl.handle.net/1887/44267 holds various files of this Leiden University dissertation. Author: Spierings, M.J. Title: The music of language : exploring grammar, prosody and

Nadere informatie

Cover Page. The handle http://hdl.handle.net/1887/20183 holds various files of this Leiden University dissertation.

Cover Page. The handle http://hdl.handle.net/1887/20183 holds various files of this Leiden University dissertation. Cover Page The handle http://hdl.handle.net/1887/20183 holds various files of this Leiden University dissertation. Author: Rooden, Stephanie Maria van Title: Clinical patterns in Parkinson s disease Date:

Nadere informatie

Cover Page. The handle http://hdl.handle.net/1887/22739 holds various files of this Leiden University dissertation.

Cover Page. The handle http://hdl.handle.net/1887/22739 holds various files of this Leiden University dissertation. Cover Page The handle http://hdl.handle.net/1887/22739 holds various files of this Leiden University dissertation. Author: Barzouhi, Abdelilah el Title: Paradigm shift in MRI for sciatica Issue Date: 2013-12-03

Nadere informatie

Cover Page. The handle http://hdl.handle.net/1887/21978 holds various files of this Leiden University dissertation.

Cover Page. The handle http://hdl.handle.net/1887/21978 holds various files of this Leiden University dissertation. Cover Page The handle http://hdl.handle.net/1887/21978 holds various files of this Leiden University dissertation. Author: Goeij, Moniek Cornelia Maria de Title: Disease progression in pre-dialysis patients:

Nadere informatie

Cover Page. The handle http://hdl.handle.net/1887/35287 holds various files of this Leiden University dissertation

Cover Page. The handle http://hdl.handle.net/1887/35287 holds various files of this Leiden University dissertation Cover Page The handle http://hdl.handle.net/1887/35287 holds various files of this Leiden University dissertation Author: Poortvliet, Rosalinde Title: New perspectives on cardiovascular risk prediction

Nadere informatie

Cover Page. The handle http://hdl.handle.net/1887/22989 holds various files of this Leiden University dissertation

Cover Page. The handle http://hdl.handle.net/1887/22989 holds various files of this Leiden University dissertation Cover Page The handle http://hdl.handle.net/1887/22989 holds various files of this Leiden University dissertation Author: Pouw, Lucinda Title: Emotion regulation in children with Autism Spectrum Disorder

Nadere informatie

Cover Page. The handle http://hdl.handle.net/1887/33222 holds various files of this Leiden University dissertation

Cover Page. The handle http://hdl.handle.net/1887/33222 holds various files of this Leiden University dissertation Cover Page The handle http://hdl.handle.net/1887/33222 holds various files of this Leiden University dissertation Author: Braak, Bas ter Title: Carcinogenicity of insulin analogues Issue Date: 2015-06-18

Nadere informatie

Cover Page. The handle holds various files of this Leiden University dissertation

Cover Page. The handle  holds various files of this Leiden University dissertation Cover Page The handle http://hdl.handle.net/1887/33063 holds various files of this Leiden University dissertation Author: Tan, Melanie Title: Clinical aspects of recurrent venous thromboembolism Issue

Nadere informatie

Cover Page. The handle http://hdl.handle.net/1887/19049 holds various files of this Leiden University dissertation.

Cover Page. The handle http://hdl.handle.net/1887/19049 holds various files of this Leiden University dissertation. Cover Page The handle http://hdl.handle.net/1887/19049 holds various files of this Leiden University dissertation. Author: Lindenburg, Petrus Wilhelmus Title: New electromigration-driven enrichment techniques

Nadere informatie

Cover Page. The handle holds various files of this Leiden University dissertation

Cover Page. The handle  holds various files of this Leiden University dissertation Cover Page The handle http://hdl.handle.net/1887/32003 holds various files of this Leiden University dissertation Author: Yuanyuan Zhao Title: Modelling the dynamics of the innovation process : a data-driven

Nadere informatie

Cover Page. The handle http://hdl.handle.net/1887/20304 holds various files of this Leiden University dissertation.

Cover Page. The handle http://hdl.handle.net/1887/20304 holds various files of this Leiden University dissertation. Cover Page The handle http://hdl.handle.net/1887/20304 holds various files of this Leiden University dissertation. Author: Wietmarschen, Herman van Title: A systems approach to sub-typing of rheumatoid

Nadere informatie

Cover Page. The handle http://hdl.handle.net/1887/33966 holds various files of this Leiden University dissertation.

Cover Page. The handle http://hdl.handle.net/1887/33966 holds various files of this Leiden University dissertation. Cover Page The handle http://hdl.handle.net/1887/3366 holds various files of this Leiden University dissertation. Author: Dijk, Marieke van Title: Type 1 diabetes and sleep : implications for glucoregulation

Nadere informatie

Cover Page. The handle holds various files of this Leiden University dissertation.

Cover Page. The handle  holds various files of this Leiden University dissertation. Cover Page The handle http://hdl.handle.net/1887/29740 holds various files of this Leiden University dissertation. Author: Booij, Suzanne José Title: Wishes for the end of life in Huntington's Disease.

Nadere informatie

Cover Page. The handle holds various files of this Leiden University dissertation.

Cover Page. The handle  holds various files of this Leiden University dissertation. Cover Page The handle http://hdl.handle.net/1887/41339 holds various files of this Leiden University dissertation. Author: Karasneh, B.H.A. Title: An online corpus of UML Design Models : construction and

Nadere informatie

Cover Page. The handle holds various files of this Leiden University dissertation.

Cover Page. The handle  holds various files of this Leiden University dissertation. Cover Page The handle http://hdl.handle.net/1887/20843 holds various files of this Leiden University dissertation. Author: Schramm, Sebastian Markus Title: Imaging with aberration-corrected low energy

Nadere informatie

Cover Page. The handle holds various files of this Leiden University dissertation

Cover Page. The handle  holds various files of this Leiden University dissertation Cover Page The handle http://hdl.handle.net/1887/39720 holds various files of this Leiden University dissertation Author: Hafkemeijer, Anne Title: Brain networks in aging and dementia Issue Date: 2016-05-26

Nadere informatie

Cover Page. The handle http://hdl.handle.net/1887/18632 holds various files of this Leiden University dissertation.

Cover Page. The handle http://hdl.handle.net/1887/18632 holds various files of this Leiden University dissertation. Cover Page The handle http://hdl.handle.net/1887/18632 holds various files of this Leiden University dissertation. Author: Joosse, Simon Andreas Title: Prediction of "BRCAness" in breast cancer by array

Nadere informatie

Cover Page. The handle http://hdl.handle.net/1887/19772 holds various files of this Leiden University dissertation.

Cover Page. The handle http://hdl.handle.net/1887/19772 holds various files of this Leiden University dissertation. Cover Page The handle http://hdl.handle.net/1887/19772 holds various files of this Leiden University dissertation. Author: Bertens, Laura M.F. Title: Computerised modelling for developmental biology :

Nadere informatie

Cover Page. The handle holds various files of this Leiden University dissertation.

Cover Page. The handle  holds various files of this Leiden University dissertation. Cover Page The handle http://hdl.handle.net/1887/36422 holds various files of this Leiden University dissertation. Author: Díaz Morales, Oscar Alfonso Title: Catalysis of the electrochemical water oxidation

Nadere informatie

Cover Page. The handle holds various files of this Leiden University dissertation.

Cover Page. The handle  holds various files of this Leiden University dissertation. Cover Page The handle http://hdl.handle.net/1887/25829 holds various files of this Leiden University dissertation. Author: Nunspeet, Félice van Title: Neural correlates of the motivation to be moral Issue

Nadere informatie

Cover Page. The handle holds various files of this Leiden University dissertation.

Cover Page. The handle  holds various files of this Leiden University dissertation. Cover Page The handle http://hdl.handle.net/1887/44704 holds various files of this Leiden University dissertation. Author: Arbainsyah Title: The impact of sustainable forest management on plant and bird

Nadere informatie

Cover Page. The handle holds various files of this Leiden University dissertation

Cover Page. The handle  holds various files of this Leiden University dissertation Cover Page The handle http://hdl.handle.net/1887/28966 holds various files of this Leiden University dissertation Author: Heeres, Erwin Title: Manipulating carbon nanotubes towards the application as novel

Nadere informatie

Cover Page. The handle http://hdl.handle.net/1887/20859 holds various files of this Leiden University dissertation.

Cover Page. The handle http://hdl.handle.net/1887/20859 holds various files of this Leiden University dissertation. Cover Page The handle http://hdl.handle.net/1887/20859 holds various files of this Leiden University dissertation. Author: Drees, Johanna Marijke Title: Rabbits in the coastal sand dunes : weighed and

Nadere informatie

Cover Page. The handle http://hdl.handle.net/1887/36145 holds various files of this Leiden University dissertation.

Cover Page. The handle http://hdl.handle.net/1887/36145 holds various files of this Leiden University dissertation. Cover Page The handle http://hdl.handle.net/1887/36145 holds various files of this Leiden University dissertation. Author: Turner, Monica L. Title: Metals in the diffuse gas around high-redshift galaxies

Nadere informatie

Cover Page. The handle http://hdl.handle.net/1887/35283 holds various files of this Leiden University dissertation

Cover Page. The handle http://hdl.handle.net/1887/35283 holds various files of this Leiden University dissertation Cover Page The handle http://hdl.handle.net/1887/35283 holds various files of this Leiden University dissertation Author: Charehbili, Ayoub Title: Optimising preoperative systemic therapy for breast cancer

Nadere informatie

Cover Page. The handle http://hdl.handle.net/1887/36998 holds various files of this Leiden University dissertation.

Cover Page. The handle http://hdl.handle.net/1887/36998 holds various files of this Leiden University dissertation. Cover Page The handle http://hdl.handle.net/1887/36998 holds various files of this Leiden University dissertation. Author: Dunnen, Angela den Title: Surface-structure dependencies in catalytic reactions

Nadere informatie

Cover Page. The handle http://hdl.handle.net/1887/32744 holds various files of this Leiden University dissertation

Cover Page. The handle http://hdl.handle.net/1887/32744 holds various files of this Leiden University dissertation Cover Page The handle http://hdl.handle.net/1887/32744 holds various files of this Leiden University dissertation Author: Heemskerk, Anne-Wil Title: Dysphagia in Huntington s disease Issue Date: 2015-04-15

Nadere informatie

Cover Page. The handle holds various files of this Leiden University dissertation.

Cover Page. The handle  holds various files of this Leiden University dissertation. Cover Page The handle http://hdl.handle.net/1887/44385 holds various files of this Leiden University dissertation. Author: Ayata, C. Title: Spreading depolarizations : the missing link between mirgraine

Nadere informatie

Cover Page. Author: Laffoon, Jason Eric Title: Patterns of paleomobility in the ancient Antilles : an isotopic approach Issue Date: 2012-10-31

Cover Page. Author: Laffoon, Jason Eric Title: Patterns of paleomobility in the ancient Antilles : an isotopic approach Issue Date: 2012-10-31 Cover Page The handle http://hdl.handle.net/1887/20072 holds various files of this Leiden University dissertation. Author: Laffoon, Jason Eric Title: Patterns of paleomobility in the ancient Antilles :

Nadere informatie

Cover Page. The handle holds various files of this Leiden University dissertation.

Cover Page. The handle  holds various files of this Leiden University dissertation. Cover Page The handle http://hdl.handle.net/1887/29764 holds various files of this Leiden University dissertation. Author: Takes, Frank Willem Title: Algorithms for analyzing and mining real-world graphs

Nadere informatie

Cover Page. The handle http://hdl.handle.net/1887/18950 holds various files of this Leiden University dissertation.

Cover Page. The handle http://hdl.handle.net/1887/18950 holds various files of this Leiden University dissertation. Cover Page The handle http://hdl.handle.net/1887/18950 holds various files of this Leiden University dissertation. Author: Velthuis, Arend Jan Wouter te Title: A biochemical portrait of the nidovirus RNA

Nadere informatie

Normal operating range of the microbial community under potato Inceolu, Özgul

Normal operating range of the microbial community under potato Inceolu, Özgul Normal operating range of the microbial community under potato Inceolu, Özgul IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check

Nadere informatie

Cover Page. The handle http://hdl.handle.net/1887/26922 holds various files of this Leiden University dissertation

Cover Page. The handle http://hdl.handle.net/1887/26922 holds various files of this Leiden University dissertation Cover Page The handle http://hdl.handle.net/1887/26922 holds various files of this Leiden University dissertation Author: Shah, Dipen M. Title: NMR structural studies of protein-small molecule interactions

Nadere informatie

Cover Page. The handle http://hdl.handle.net/1887/21706 holds various files of this Leiden University dissertation.

Cover Page. The handle http://hdl.handle.net/1887/21706 holds various files of this Leiden University dissertation. Cover Page The handle http://hdl.handle.net/1887/21706 holds various files of this Leiden University dissertation. Author: Overberg, Regina Ingrid Title: Breast cancer stories on the internet : improving

Nadere informatie

Cover Page. The handle holds various files of this Leiden University dissertation

Cover Page. The handle  holds various files of this Leiden University dissertation Cover Page The handle http://hdl.handle.net/1887/28464 holds various files of this Leiden University dissertation Author: Jeroen Bédorf Title: The gravitational billion body problem / Het miljard deeltjes

Nadere informatie

Cover Page. The handle http://hdl.handle.net/1887/20932 holds various files of this Leiden University dissertation.

Cover Page. The handle http://hdl.handle.net/1887/20932 holds various files of this Leiden University dissertation. Cover Page The handle http://hdl.handle.net/1887/20932 holds various files of this Leiden University dissertation. Author: Haar, Sita Minke ter Title: Birds and babies : a comparison of the early development

Nadere informatie

Cover Page. The handle holds various files of this Leiden University dissertation.

Cover Page. The handle  holds various files of this Leiden University dissertation. Cover Page The handle http://hdl.handle.net/1887/23449 holds various files of this Leiden University dissertation. Author: Roach, Rachel Elizabeth Jo Title: Sex-specific aspects of venous thrombosis Issue

Nadere informatie

Cover Page. The handle http://hdl.handle.net/1887/37023 holds various files of this Leiden University dissertation.

Cover Page. The handle http://hdl.handle.net/1887/37023 holds various files of this Leiden University dissertation. Cover Page The handle http://hdl.handle.net/1887/37023 holds various files of this Leiden University dissertation. Author: Wong, Chung Sing Title: The synthesis of mannose-derived bioconjugates and enzyme

Nadere informatie

Cover Page. The handle http://hdl.handle.net/1887/29755 holds various files of this Leiden University dissertation.

Cover Page. The handle http://hdl.handle.net/1887/29755 holds various files of this Leiden University dissertation. Cover Page The handle http://hdl.handle.net/1887/29755 holds various files of this Leiden University dissertation. Author: Moes, Dirk Jan Alie Roelof Title: Optimizing immunosuppression with mtor inhibitors

Nadere informatie

Cover Page. The handle holds various files of this Leiden University dissertation.

Cover Page. The handle  holds various files of this Leiden University dissertation. Cover Page The handle http://hdl.handle.net/1887/40073 holds various files of this Leiden University dissertation. Author: Schat, A. Title: Clinical epidemiology of commonly occurring anxiety disorders

Nadere informatie

Duurzame landbouw door bodemschimmels

Duurzame landbouw door bodemschimmels Duurzame landbouw door bodemschimmels Omdat er in natuurgebieden over het algemeen veel bodemschimmels leven, wordt vaak gedacht dat de aanwezigheid van schimmels in een akker of in grasland een kenmerk

Nadere informatie

Cover Page. The handle holds various files of this Leiden University dissertation.

Cover Page. The handle  holds various files of this Leiden University dissertation. Cover Page The handle http://hdl.handle.net/1887/38701 holds various files of this Leiden University dissertation. Author: Visschedijk, Johannes Hermanus Maria (Jan) Title: Fear of falling in older patients

Nadere informatie

Cover Page. The handle holds various files of this Leiden University dissertation.

Cover Page. The handle  holds various files of this Leiden University dissertation. Cover Page The handle http://hdl.handle.net/1887/19934 holds various files of this Leiden University dissertation. Author: Pat El, Ron Jonathan Title: Lost in translation : congruency of teacher and student

Nadere informatie

Cover Page. The handle http://hdl.handle.net/1887/20225 holds various files of this Leiden University dissertation.

Cover Page. The handle http://hdl.handle.net/1887/20225 holds various files of this Leiden University dissertation. Cover Page The handle http://hdl.handle.net/1887/20225 holds various files of this Leiden University dissertation. Author: Heijstek, Werner Title: Architecture design in global and model-centric software

Nadere informatie

Cover Page. The handle http://hdl.handle.net/1887/20488 holds various files of this Leiden University dissertation.

Cover Page. The handle http://hdl.handle.net/1887/20488 holds various files of this Leiden University dissertation. Cover Page The handle http://hdl.handle.net/1887/20488 holds various files of this Leiden University dissertation. Author: Haar, Beryl Philine ter Title: Open method of coordination. An analysis of its

Nadere informatie

Cover Page. Author: Vu, Van Thieu Title: Opportunities for performance optimization of applications through code generation Issue Date:

Cover Page. Author: Vu, Van Thieu Title: Opportunities for performance optimization of applications through code generation Issue Date: Cover Page The handle http://hdl.handle.net/1887/18622 holds various files of this Leiden University dissertation. Author: Vu, Van Thieu Title: Opportunities for performance optimization of applications

Nadere informatie

Cover Page. The handle http://hdl.handle.net/1887/32015 holds various files of this Leiden University dissertation.

Cover Page. The handle http://hdl.handle.net/1887/32015 holds various files of this Leiden University dissertation. Cover Page The handle http://hdl.handle.net/17/32015 holds various files of this Leiden University dissertation. Author: Akker, Erik Ben van den Title: Computational biology in human aging : an omics data

Nadere informatie

Cover Page. The handle holds various files of this Leiden University dissertation

Cover Page. The handle  holds various files of this Leiden University dissertation Cover Page The handle http://hdl.handle.net/1887/36421 holds various files of this Leiden University dissertation Author: Kai Fang Title: Environmental footprints : assessing anthropogenic effects on the

Nadere informatie

Cover Page. The handle holds various files of this Leiden University dissertation

Cover Page. The handle  holds various files of this Leiden University dissertation Cover Page The handle http://hdl.handle.net/1887/45778 holds various files of this Leiden University dissertation Author: Korndewal, Marjolein Title: Consequences of congenital cytomegalovirus infection

Nadere informatie

Cover Page. The handle holds various files of this Leiden University dissertation

Cover Page. The handle  holds various files of this Leiden University dissertation Cover Page The handle http://hdl.handle.net/1887/44297 holds various files of this Leiden University dissertation Author: Valk, Ramon van der Title: Responding to environmental cues : the adaptive qualities

Nadere informatie

Cover Page. The handle holds various files of this Leiden University dissertation

Cover Page. The handle  holds various files of this Leiden University dissertation Cover Page The handle http://hdl.handle.net/1887/35176 holds various files of this Leiden University dissertation Author: Lindenburg, Irene Title: Intrauterine blood transfusion : indications, risks, quality

Nadere informatie

Cover Page. The handle holds various files of this Leiden University dissertation

Cover Page. The handle  holds various files of this Leiden University dissertation Cover Page The handle http://hdl.handle.net/1887/21792 holds various files of this Leiden University dissertation Author: Timmer, Kalinka Title: A cross-linguistics investigation of the onset effect in

Nadere informatie

Cover Page. The handle http://hdl.handle.net/1887/25815 holds various files of this Leiden University dissertation.

Cover Page. The handle http://hdl.handle.net/1887/25815 holds various files of this Leiden University dissertation. Cover Page The handle http://hdl.handle.net/1887/25815 holds various files of this Leiden University dissertation. Author: Jamal, Mumtaz Title: Smoking and the course of anxiety and depression Issue Date:

Nadere informatie

Cover Page. The handle holds various files of this Leiden University dissertation.

Cover Page. The handle  holds various files of this Leiden University dissertation. Cover Page The handle http://hdl.handle.net/1887/19052 holds various files of this Leiden University dissertation. Author: Manti, Eirini Title: From Categories to dimensions to evaluations : assessment

Nadere informatie

Cover Page. Author: Smelt, Antonette Title: Treatment of migraine : from clinical trial to general practice Issue Date: 2014-05-14

Cover Page. Author: Smelt, Antonette Title: Treatment of migraine : from clinical trial to general practice Issue Date: 2014-05-14 Cover Page The handle http://hdl.handle.net/1887/25761 holds various files of this Leiden University dissertation Author: Smelt, Antonette Title: Treatment of migraine : from clinical trial to general

Nadere informatie

Cover Page. The handle http://hdl.handle.net/1887/26944 holds various files of this Leiden University dissertation

Cover Page. The handle http://hdl.handle.net/1887/26944 holds various files of this Leiden University dissertation Cover Page The handle http://hdl.handle.net/1887/26944 holds various files of this Leiden University dissertation Author: Verschoor, Stephan Alexander Title: Learning about goals : development of action

Nadere informatie

Cover Page. The handle holds various files of this Leiden University dissertation.

Cover Page. The handle  holds various files of this Leiden University dissertation. Cover Page The handle http://hdl.handle.net/1887/37000 holds various files of this Leiden University dissertation. Author: Beletkaia, Elena Title: Mechanisms of Ewing sarcoma metastasis : biochemistry

Nadere informatie

DLV Aktua Chrysant. Zwaardere takken in chrysant met Trianum (Trichoderma harzianum T-22)

DLV Aktua Chrysant. Zwaardere takken in chrysant met Trianum (Trichoderma harzianum T-22) DLV Aktua Chrysant Zwaardere takken in chrysant met Trianum (Trichoderma harzianum T-22) De laatste tijd is er veel aandacht voor ziekteweerbaarheid van de bodem. Eén van de organismen die hierbij regelmatig

Nadere informatie

Cover Page. The handle holds various files of this Leiden University dissertation.

Cover Page. The handle  holds various files of this Leiden University dissertation. Cover Page The handle http://hdl.handle.net/1887/28740 holds various files of this Leiden University dissertation. Author: Kadrouch-Outmany, Khadija Title: Islamic burials in the Netherlands and Belgium.

Nadere informatie

Cover Page. The handle http://hdl.handle.net/1887/35756 holds various files of this Leiden University dissertation.

Cover Page. The handle http://hdl.handle.net/1887/35756 holds various files of this Leiden University dissertation. Cover Page The handle http://hdl.handle.net/1887/35756 holds various files of this Leiden University dissertation. Author: Hamid, Firdaus Title: Helminth infections, socio-economic status and allergies

Nadere informatie

Cover Page. The handle holds various files of this Leiden University dissertation.

Cover Page. The handle  holds various files of this Leiden University dissertation. Cover Page The handle http://hdl.handle.net/1887/26110 holds various files of this Leiden University dissertation. Author: Raps, Marjolein Title: Effectiveness and side effects of hormonal contraceptives

Nadere informatie

Cover Page. The handle holds various files of this Leiden University dissertation.

Cover Page. The handle  holds various files of this Leiden University dissertation. Cover Page The handle http://hdl.handle.net/1887/31632 holds various files of this Leiden University dissertation. Author: Mensink, Gertjan Title: Bilateral sagittal split osteotomy by the splitter-separator

Nadere informatie

Cover Page. The handle http://hdl.handle.net/1887/33081 holds various files of this Leiden University dissertation.

Cover Page. The handle http://hdl.handle.net/1887/33081 holds various files of this Leiden University dissertation. Cover Page The handle http://hdl.handle.net/1887/33081 holds various files of this Leiden University dissertation. Author: Stettina, Christoph Johann Title: Governance of innovation project management

Nadere informatie

146

146 145 146 Bij genetische modificatie door middel van transgenese worden met behulp van biotechnologische technieken erfelijke eigenschappen veranderd of van het ene naar het andere organisme overgebracht.

Nadere informatie

Bijlage VMBO-KB. biologie CSE KB. tijdvak 2. Deze bijlage bevat informatie. 945-0191-a-KB-2-b

Bijlage VMBO-KB. biologie CSE KB. tijdvak 2. Deze bijlage bevat informatie. 945-0191-a-KB-2-b Bijlage VMBO-KB 2009 tijdvak 2 biologie CSE KB Deze bijlage bevat informatie. 945-0191-a-KB-2-b Informatie - Aardappels Lees eerst informatie 1 tot en met 8 en beantwoord dan vraag 39 tot en met 48. Bij

Nadere informatie

Cover Page. The handle http://hdl.handle.net/1887/22238 holds various files of this Leiden University dissertation

Cover Page. The handle http://hdl.handle.net/1887/22238 holds various files of this Leiden University dissertation Cover Page The handle http://hdl.handle.net/1887/22238 holds various files of this Leiden University dissertation Author: Verbiest, Gerard Jan Title: Unravelling heterodyne force microscopy Issue Date:

Nadere informatie

Cover Page. The handle holds various files of this Leiden University dissertation.

Cover Page. The handle  holds various files of this Leiden University dissertation. Cover Page The handle http://hdl.handle.net/1887/19103 holds various files of this Leiden University dissertation. Author: Pisanti, Renato Title: Beyond the job demand control (-support) model : explaining

Nadere informatie

Cover Page. The handle holds various files of this Leiden University dissertation

Cover Page. The handle  holds various files of this Leiden University dissertation Cover Page The handle http://hdl.handle.net/1887/29692 holds various files of this Leiden University dissertation Author: Bonten, Tobias N. Title: Time for aspirin : blood pressure and reactivity Issue

Nadere informatie

Cover Page. Author: Beuzekom, Martie van Title: Latent risk factors in operating theatres and intensive care units Issue Date:

Cover Page. Author: Beuzekom, Martie van Title: Latent risk factors in operating theatres and intensive care units Issue Date: Cover Page The handle http://hdl.handle.net/1887/19916 holds various files of this Leiden University dissertation. Author: Beuzekom, Martie van Title: Latent risk factors in operating theatres and intensive

Nadere informatie

Cover Page. The handle holds various files of this Leiden University dissertation

Cover Page. The handle  holds various files of this Leiden University dissertation Cover Page The handle http://hdl.handle.net/1887/43990 holds various files of this Leiden University dissertation Author: Hiemstra, Steven Title: High throughput microscopy of mechanism-based reporters

Nadere informatie

Chapter 9 CHAPTER 9. Samenvatting

Chapter 9 CHAPTER 9. Samenvatting CHAPTER 9 Samenvatting 115 Kanker en behandelingen voor kanker kunnen grote invloed hebben op de lichamelijke gezondheid en het psychisch functioneren van mensen. Er is veel onderzoek gedaan naar de effectiviteit

Nadere informatie

Cover Page. The handle http://hdl.handle.net/1887/20846 holds various files of this Leiden University dissertation.

Cover Page. The handle http://hdl.handle.net/1887/20846 holds various files of this Leiden University dissertation. Cover Page The handle http://hdl.handle.net/1887/20846 holds various files of this Leiden University dissertation. Author: Knittle, Keegan Title: Motivation, self-regulation and physical activity among

Nadere informatie

Cover Page. The handle holds various files of this Leiden University dissertation

Cover Page. The handle  holds various files of this Leiden University dissertation Cover Page The handle http://hdl.handle.net/1887/48860 holds various files of this Leiden University dissertation Author: Rotman, M. Title: Crossing barriers, delivery of llama antibody fragments into

Nadere informatie

Cover Page. The handle http://hdl.handle.net/1887/28694 holds various files of this Leiden University dissertation.

Cover Page. The handle http://hdl.handle.net/1887/28694 holds various files of this Leiden University dissertation. Cover Page The handle http://hdl.handle.net/1887/28694 holds various files of this Leiden University dissertation. Author: Penning, Maria Elisabeth (Marlies) Title: Issue Date: 2014-09-10 Pre-eclampsie

Nadere informatie

Cover Page. The handle holds various files of this Leiden University dissertation.

Cover Page. The handle  holds various files of this Leiden University dissertation. Cover Page The handle http://hdl.handle.net/1887/20310 holds various files of this Leiden University dissertation. Author: Jansen, Bas Title: Mersenne primes and class field theory Date: 2012-12-18 Samenvatting

Nadere informatie

Bijlage VMBO-GL en TL 2004

Bijlage VMBO-GL en TL 2004 Bijlage VMBO-GL en TL 2004 tijdvak 1 BIOLOGIE CSE GL EN TL BIOLOGIE VBO-MAVO-D Deze bijlage bevat informatie. 400009-1-586-543b BIOTECHNOLOGIE INFORMATIE 1 OUDE TECHNIEKEN Al eeuwen gebruiken mensen organismen

Nadere informatie

Cover Page. The handle holds various files of this Leiden University dissertation.

Cover Page. The handle  holds various files of this Leiden University dissertation. Cover Page The handle http://hdl.handle.net/1887/28736 holds various files of this Leiden University dissertation. Author: Debeij, Jan Title: The effect of thyroid hormone on haemostasis and thrombosis

Nadere informatie

Cover Page. The handle holds various files of this Leiden University dissertation.

Cover Page. The handle  holds various files of this Leiden University dissertation. Cover Page The handle http://hdl.handle.net/1887/33229 holds various files of this Leiden University dissertation. Author: Rooden, Sanneke van Title: MR imaging in cerebral amyloidoses : entering a new

Nadere informatie

Figuur 1. Representatie van de dubbele helix en de structuren van de verschillende basen.

Figuur 1. Representatie van de dubbele helix en de structuren van de verschillende basen. Het DNA molecuul is verantwoordelijk voor het opslaan van de genetische informatie die gebruikt wordt voor de ontwikkeling en het functioneren van levende organismen. Aangezien het de instructies voor

Nadere informatie

Cover Page. The handle holds various files of this Leiden University dissertation

Cover Page. The handle  holds various files of this Leiden University dissertation Cover Page The handle http://hdl.handle.net/1887/45220 holds various files of this Leiden University dissertation Author: Vries, Bart de Title: Burgemeesters in crisistijd : de invloed van context en persoonlijkheid

Nadere informatie