University of Groningen. Epidemiology of Dupuytren disease unraveled Broekstra, Dieuwke

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1 University of Groningen Epidemiology of Dupuytren disease unraveled Broekstra, Dieuwke IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below. Document Version Publisher's PDF, also known as Version of record Publication date: 2017 Link to publication in University of Groningen/UMCG research database Citation for published version (APA): Broekstra, D. (2017). Epidemiology of Dupuytren disease unraveled: Prevalence, risk factors and disease course [Groningen]: Rijksuniversiteit Groningen Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons). Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Downloaded from the University of Groningen/UMCG research database (Pure): For technical reasons the number of authors shown on this cover page is limited to 10 maximum. Download date:

2 Epidemiology of Dupuytren disease unraveled Prevalence, risk factors and disease course

3 This PhD project was financially supported by The University Medical Center Groningen - Graduate School of Medical Sciences, and the C&W de Boer foundation. Financial support for printing of this thesis was kindly provided by the University Medical Center Groningen - Graduate School of Medical Sciences, BAPmedical and Pfizer. ISBN: ISBN (electronic version): Copyright 2017 Dieuwke Broekstra All rights are reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means without written permission of the author or the publisher holding the copyright of the published articles. Cover: Dieuwke Broekstra Layout: Dieuwke Broekstra Printed by: Ridderprint BV, Ridderkerk The cover represents a nodule in a Dupuytren cord. The word nodule is derived from the Latin word nodus, which means knot. In a progressed stage, Dupuytren cells align and form a cord, which is represented by the strings that are placed in one line.

4 Epidemiology of Dupuytren disease unraveled Prevalence, risk factors and disease course Proefschrift ter verkrijging van de graad doctor aan de Rijksuniversiteit Groningen op gezag van de rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties. De openbare verdediging zal plaatsvinden op woensdag 27 september om 14:30 uur door Dieuwke Christina Broekstra Geboren op 14 februari 1987 te Winterswijk

5 Promotores Prof. dr. P.M.N. Werker Prof. dr. E.R. van den Heuvel Beoordelingscommissie Prof. dr. G.H. de Bock Prof. D. Furniss, DM, FRCS(Plast) Prof. dr. I. Degreef Paranimfen S.F. Broekstra, BSc R. Lanting, MD, PhD

6 Voor mijn ouders Zij die nieuwsgierigheid hebben aangemoedigd, doorzettingsvermogen hebben aangeleerd, zij die altijd in mij hebben geloofd, die nog altijd in mij geloven en mij hebben geleerd om in mezelf te geloven

7 TABLE OF CONTENTS Chapter 1. General introduction 8 Part I. Prevalence and risk factors Chapter 2. A systematic review and meta-analysis on the prevalence 22 of Dupuytren disease in the general population of Western countries Chapter 3. A systematic review and meta-analysis on the strength and 46 consistency of the associations between Dupuytren disease, diabetes mellitus, liver disease and epilepsy Chapter 4. Dupuytren disease is highly prevalent in field hockey 76 players aged over 60 years

8 Part II. Considerations on the measurement methods Chapter 5. Intra- and inter-observer agreement on diagnosis of 96 Dupuytren disease, measurements of severity of contracture, and disease extent Chapter 6. Clinimetric properties of the Dutch URAM and its 116 ability to detect Dupuytren disease progression compared to the MHQ Part III. Natural course of Dupuytren disease Chapter year results of a prospective cohort study on disease 136 course of primary Dupuytren disease Chapter 8. General discussion 162 Part IV. Summary, Samenvatting, CV, Dankwoord