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1 Cover Page The handle holds various files of this Leiden University dissertation. Author: Wardenaar, Klaas Johan Title: Syndromes versus symptoms : towards validation of a dimensional approach of depression and anxiety Date:

2 Curriculum Vitae Curriculum Vitae On the 20th of February 1983 Klaas Wardenaar was born in Heerhugowaard, the Netherlands. He finished his secondary education at the Stedelijk Gymnasium Arnhem in 2000 and in the same year, he started his study of psychology at the Radboud University Nijmegen. In the process of obtaining his master s degree in neuro- and rehabilitation psychology, Klaas did an internship at the department of psychiatry of the University Medical Centre in Utrecht in Here, he conducted neuropsychological assessments and psychiatric screenings with schizophrenia patients. In the following year, he did his research internship at the Clinical Neuroscience Lab of the University of California Los Angeles (UCLA) in Los Angeles, California. In 2006, Klaas graduated and worked as a neuropsychologist at GGZ Meerkanten in Ermelo. From the beginning of 2007 until the end of 2011, Klaas has worked on the research, presented in this dissertation. During this period, he earned a post-doctoral master s degree in epidemiology from the Vrije Universiteit in Amsterdam. Currently, Klaas works as a postdoctoral researcher at the Interdisciplinary Centre of Psychopathology and Emotion regulation (ICPE) of the department of psychiatry at the University Medical Centre in Groningen. In his research, he focusses on ways to deconstruct heterogeneous psychopathological constructs into more homogeneous entities, in order to increase the specificity of psychiatric diagnostics. 181

3 List of Publications Publications Wardenaar, KJ, Giltay, EJ, van Veen, T, Zitman, FG, Penninx, BWJH. Dimensions of the Inventory of Depressive Symptomatology as Predictors of the Course of Depressive and Anxiety Disorders. Journal of Psychiatric Research (in press). Carlier, IV, Schulte-van Maaren, YWM, Wardenaar, KJ, Giltay, EJ, van Noorden, MS, Vergeer, P, Zitman, FG. Construction of a new measure for the assessment of psychological distress: a validation study of the Symptom Questionnaire (SQ) 48 in clinical and nonclinical samples. Psychiatry Research. Electronic publication ahead of print. Hegeman, JM*, Wardenaar, KJ*, Comijs, HC, ter Waal, MW, Kok, RM, van der Mast, R (2012). The structure and dimensionality of depressive symptomatology in the elderly. *) Shared first authors. Journal of Psychiatric Research. Electronic publication ahead of print. Wardenaar, KJ*, Wigman, JTW*, Lin, A, Killackey, E, Collip, D, Wood, SJ, Ryan, J, Baksheev, G, Cosgrave, E, Yung, AR. (2012). Development and validation of a new measure of everyday adolescent functioning: the Multidimensional Adolescent Functioning Scale. *) shared first authors. Journal of Adolescent Health. Electronic publication ahead of print. van Veen, T, Goeman, J, Monajemi, R, Wardenaar, KJ, Hartman, CA, Snieder, H, Nolte, IM, Penninx, BWJH, Zitman, FG. (2012) Different gene sets contribute to different symptom dimensions of depression and anxiety. American Journal of Medical Genetics part B: Neuropsychiatric Genetics. Electronic publication ahead of print. Wardenaar, KJ, Giltay, EJ, van Veen, T, Zitman, FG, Penninx, BWJH (2012). Symptom dimensions as predictors of the two-year course of depressive and anxiety disorders. Journal of Affective Disorders 136: den Hollander-Gijsman, ME, Wardenaar, KJ, van der Wee, NJA, de Beurs, E, Mooijaart, A, Zitman, FG (2012). Distinguishing between symptom-dimensions of depression and anxiety: an integrative approach. Journal of Affective Disorders 136: Wieland, J, Wardenaar, KJ, Fontein, E, Zitman, FG (2011). The utility of the brief symptom inventory in people with intellectual disabilities. Journal of Intellectual Disability Research, Electronic publication ahead of print. Luppino, FS, van Reedt-Dortland, AKB, Wardenaar, KJ, Bouvy, PF, Giltay, EJ, Zitman, FG, Penninx, BWJH (2011). Somatic arousal is associated with somatic symptoms of the metabolic syndrome. Psychosomatic Medicine 73: Wardenaar, KJ, Vreeburg, SA, van Veen, T, Giltay, EJ, Penninx, BWJH, Zitman, FG (2011) Dimensions of depression and anxiety and the Hypothalamo-Pituitary-Adrenal-axis. Biological Psychiatry 69: Wardenaar, KJ, van Veen, T, Giltay, EJ, Penninx, BWJH, Zitman, FG (2010). Development and validation of a 30 item short adaptation of the Mood and Anxiety Symptoms Questionnaire (MASQ). Psychiatry Research 179: Wardenaar, KJ, Van Veen, T, Giltay, EJ, Den Hollander-Gijsman, ME, Penninx, BWJH, Zitman, FG (2010) The structure and dimensionality of the Inventory of Depressive Symptomatology Self Report (IDS-SR) in patients with depressive disorder and healthy controls. Journal of Affective Disorders 125:

4 Dankwoord Dankwoord Dit proefschrift was niet - of met aanzienlijk meer moeite - tot stand gekomen zonder de hulp en betrokkenheid van vele mensen. Al deze mensen wil ik hierbij bedanken en een aantal in het bijzonder. Allereerst wil ik mijn co-promotores Erik Giltay en Tineke van Veen bedanken voor hun goede, leerzame en inspirerende begeleiding in de afgelopen jaren. Onze wekelijkse bijeenkomsten waren altijd zeer nuttig, maar beter nog, ook altijd erg gezellig. Ook mijn promotores Frans Zitman en Brenda Penninx ben ik veel dank verschuldigd. Ondanks het feit dat ze beiden altijd een onmenselijk drukke planning hadden, toonden zij tijdens onze maandelijkse bijeenkomsten altijd grote betrokkenheid bij mijn onderzoek en mijn persoonlijke ontwikkeling. De afgelopen vijf jaren waren een stuk minder plezierig geweest zonder de vele collega s die ik in het LUMC heb leren kennen. Met name mijn collega s op de kantoortuin en in het NESDA-team wil ik daarvoor hartelijk bedanken. Ik wil mijn ouders en broers bedanken voor hun steun en betrokkenheid. Op momenten van voor- en tegenspoed kon ik onvoorwaardelijk op hen rekenen. Hierdoor kon ik mij vol vertrouwen overleveren aan de grillen en onzekerheden die soms bij het leven van een wetenschappelijk onderzoeker horen. Ten slotte wil ik mijn vriendin Hanneke bedanken omdat zij als geen ander vanuit haar eigen ervaring met mij mee kon denken over alle aspecten van het onderzoek doen. Dit is van onschatbare waarde geweest voor de totstandkoming van dit proefschrift. Ik ben haar echter bovenal dankbaar voor het feit dat ze mijn leven elke dag weer liefdevol en kleurrijk maakt. 183

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